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Human HMGB2 Protein expressed in Hi-5 - ABIN667939
Bustin, Lehn, Landsman: Structural features of the HMG chromosomal proteins and their genes. in Biochimica et biophysica acta 1990
Show all 2 references for ABIN667939
Human HMGB2 Protein expressed in Wheat germ - ABIN1306802
Wähämaa, Vallerskog, Qin, Lunderius, LaRosa, Andersson, Harris: HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay. in Journal of leukocyte biology 2006
Lrp1 (show LRP1 Proteins)-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1 (show LRP1 Proteins).
Data show that odulation of RNA helicase DDX18 (show DDX18 Proteins) directly affects growth of tamoxifen-resistant cells, suggesting that it may be a critical downstream effector of the estrogen receptors (ERs) and high mobility group box 2 (HMGB2) complex.
siRNA-mediated silencing of HMGB2 increased the sensitivity of the head and neck squamous cell carcinoma cell lines to cisplatin and 5-fluorouracil.
the combination of a HMGB1+ and HMGB2- expression potentially predicts a poor prognosis in patients with pancreatic ductal adenocarcinoma
This study found that single nucleotide polymorphisms of HMGB1 (show HMGB1 Proteins) may serve as potential biomarkers for predicting the efficacy of platinum-based chemotherapy.
The present data suggest that HMGB2 expression is a significant prognostic factor for glioblastoma and might play an important role in cell invasion.
HMGB2 is necessary to protect colorectal cancer cells from DNA damage and efficient DNA repair and p53-mediated downregulation is a critical mechanism of modulating HMGB2 expression.
Transient local HMGB2-DNA contacts dominate the DNA-bending mechanism used by HMGB (show FAH Proteins) proteins to increase DNA flexibility.
Crohn's disease in the colon and ulcerative colitis can be differentially diagnosed using anti-HMGB/HMGB2 antibodies combined with anti-Saccharomyces cerevisiae antibodies.
The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations.
HMGB2 functions as a modulator of neurogenesis in young adult mice through regulation of neural stem cell proliferation.
Oct4 post-translational modifications (PTMs) form a positive feedback loop, which promotes Akt activation and interaction with Hmgb2 and the SET complex.
HMGB2 (but not HMGB1 (show HMGB1 Proteins)) suppresses pathologic cell growth in vivo and controls a gene expression program responsible for hypertrophic cell growth
Data show that Hmgb1 and Hmgb2 function redundantly to enhance Wnt signaling in embryos, and further suggest that integrating Wnt, Shh, and BMP signaling regulates the development of digit5 in forelimbs.
High levels of HMGB2 directly correlate with the extent of neoplastic changes in cutaneous squamous cell carcinoma. HMGB2 is an effective stimulus for cell differentiation, tumor progression, & metastatic invasion.
In human and murine cartilage, there is an aging-related loss of HMGB2 expression, ultimately leading to its complete absence.
Increased HMGB2 expression is associated with squamous cell carcinoma of skin.
an interaction between HMGB2 and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway regulates the maintenance of the superficial zone
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
high-mobility group box 2
, high mobility group protein 2
, high mobility group protein B2
, high-mobility group (nonhistone chromosomal) protein 2
, non-histone chromosomal protein
, non-histone protein HMG2