Browse our PLAU Proteins (PLAU)

Full name:
Plasminogen Activator, Urokinase Proteins (PLAU)
On www.antibodies-online.com are 58 Plasminogen Activator, Urokinase (PLAU) Proteins from 17 different suppliers available. Additionally we are shipping PLAU Antibodies (334) and PLAU Kits (108) and many more products for this protein. A total of 511 PLAU products are currently listed.
Synonyms:
ATF, BDPLT5, PLAU, QPD, u-PA, uPA, UPAM, URK
list all proteins Gene Name GeneID UniProt
PLAU 5328 P00749
PLAU 18792 P06869
PLAU 25619  

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PLAU Proteins (PLAU) by Origin

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Top referenced PLAU Proteins

  1. Human PLAU Protein expressed in Human - ABIN491612 : Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. in Circulation 2011 (PubMed)
    Show all 6 references for 491612

  2. Human PLAU Protein expressed in Human Cells - ABIN2003433 : Nagai, Hiramatsu, Kanéda, Hayasuke, Arimura, Nishida, Suyama: Molecular cloning of cDNA coding for human preprourokinase. in Gene 1985 (PubMed)
    Show all 4 references for 2003433

  3. Human PLAU Protein expressed in Human - ABIN491028 : Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011 (PubMed)

  4. Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544534 : Bryer, Fantuzzi, Van Rooijen, Koh: Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)

More Proteins for PLAU Interaction Partners

Human Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. an intricate link between caveolin-1 (show CAV1 Proteins) and Src kinase (show CSK Proteins)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (show SFTPC Proteins) expression through p53 (show TP53 Proteins) and uPA (show PRAP1 Proteins) system-mediated cross-talk, is reported.

  2. results show that the uPA (show PRAP1 Proteins)/uPAR (show PLAUR Proteins)/LRP1 (show LRP1 Proteins) system is a potential target for the development of therapeutic strategies to promote axonal recovery following a CNS injury

  3. The present research concluded that aspirin suppressed prostate cancer cell invasion by reducing MMP-9 (show MMP9 Proteins) activity and uPA (show PRAP1 Proteins) expression through decreasing of IKK-beta (show IKBKB Proteins)-mediated NF-kappaB (show NFKB1 Proteins) activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.

  4. These studies identify uPA (show PRAP1 Proteins)-dependent de-repression of vegfr1 (show FLT1 Proteins) and vegfr2 (show KDR Proteins) gene transcription through binding to HHEX/PRH (show HHEX Proteins) as a novel mechanism by which uPA (show PRAP1 Proteins) mediates the pro-angiogenic effects of VEGF (show VEGFA Proteins) and identifies a potential new target for control of pathologic angiogenesis.

  5. We concluded that overexpression of MMP-3 (show MMP3 Proteins) and uPA (show PRAP1 Proteins), altogether with diminished expression of PAI-1 (show SERPINE1 Proteins) from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.

  6. The up-regulation of uPA (show PRAP1 Proteins) mRNAs was correlated with high-risk clinicopathological features, including extrathyroid invasion, loss of cellular polarity/cohesiveness, and the BRAF (show BRAF Proteins)(V600E) mutation.

  7. In contrast to platelet-derived growth factor, all urokinase isoforms induced secretion of MMP-9 (show MMP9 Proteins) by mesenchymal stromal cells.

  8. Transplantation of uPA (show PRAP1 Proteins) gene modified mesenchymal stem cells suppressed liver fibrosis and ameliorated liver function and may be a new approach to treating liver fibrosis

  9. ApaL1 and Taq1 single nucleotide polymorphisms of the urokinase and VDR (show CYP27B1 Proteins) genes are associated with recurrent urolithiasis in a Caucasian population.

  10. 1,25D3 works as a modifier of NF-kappaB (show NFKB1 Proteins)/GPX1 (show GPX1 Proteins)/uPA (show PRAP1 Proteins) expression, inhibiting cisplatin-resistance and cell invasive ability of salivary adenoid cystic carcinoma cells

Mouse (Murine) Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. an intricate link between caveolin-1 (show CAV1 Proteins) and Src kinase (show CSK Proteins)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (show SFTPC Proteins) expression through p53 (show TP53 Proteins) and uPA system-mediated cross-talk, is reported.

  2. These studies identify uPA-dependent de-repression of vegfr1 (show FLT1 Proteins) and vegfr2 (show KDR Proteins) gene transcription through binding to HHEX/PRH (show HHEX Proteins) as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF (show VEGFA Proteins) and identifies a potential new target for control of pathologic angiogenesis.

  3. Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.

  4. GM-CSF (show CSF2 Proteins) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.

  5. Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI (show TBPL1 Proteins).

  6. we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (show PLAUR Proteins))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.

  7. Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.

  8. Study shows that the competitive expression or activity of tPA (show PLAT Proteins) and/or PAI-1 (show SERPINE1 Proteins), rather than an altered uPA expression, determines the plasmin (show PLG Proteins)-mediated Abeta (show APP Proteins) proteolysis in brains affected by Alzheimer's disease

  9. Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA.

  10. beta-elemene downregulates expression of uPA, uPAR (show PLAUR Proteins), MMP-2 (show MMP2 Proteins), and MMP-9 (show MMP9 Proteins) in a murine intraocular melanoma model

Rabbit Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.

Cow (Bovine) Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR (show PLAUR Proteins)) and plasminogen activator inhibitor-1 (PAI-1 (show SERPINE1 Proteins)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.

  2. uPA/uPAR (show PLAUR Proteins) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.

  3. These data indicated that E. coli LPS (show IRF6 Proteins) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (show PLAUR Proteins) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.

  4. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  5. stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Proteins) production, consistent with a role in extracellular matrix remodeling during follicle growth.

Pig (Porcine) Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

PLAU Protein Profile

Protein Summary

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PLAU

  • plasminogen activator, urokinase (PLAU)
  • urokinase-type plasminogen activator (CpipJ_CPIJ002131)
  • urokinase-type plasminogen activator (CpipJ_CPIJ006543)
  • urokinase-type plasminogen activator (CpipJ_CPIJ013396)
  • urokinase-type plasminogen activator (CpipJ_CPIJ013623)
  • plasminogen activator, urokinase (Plau)
  • ATF protein
  • BDPLT5 protein
  • PLAU protein
  • QPD protein
  • u-PA protein
  • uPA protein
  • UPAM protein
  • URK protein

Protein level used designations for PLAU

urokinase-type plasminogen activator , U-plasminogen activator , uPA , plasminogen activator, urokinase , plasminogen activator, urinary , Urinary plasminogen activator, urokinase , urokinase plasminogen activator preproprotein

GENE ID SPECIES
403426 Canis lupus familiaris
100171578 Pongo abelii
100302501 Ovis aries
6032874 Culex quinquefasciatus
6038214 Culex quinquefasciatus
6046380 Culex quinquefasciatus
6047199 Culex quinquefasciatus
5328 Homo sapiens
18792 Mus musculus
25619 Rattus norvegicus
100008633 Oryctolagus cuniculus
281408 Bos taurus
396424 Gallus gallus
396985 Sus scrofa
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