Browse our Jumonji Domain Containing 5 Proteins (JMJD5)

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Jumonji Domain Containing 5 Proteins (JMJD5)
On www.antibodies-online.com are 10 Jumonji Domain Containing 5 (JMJD5) Proteins from 4 different suppliers available. Additionally we are shipping Jumonji Domain Containing 5 Antibodies (64) and many more products for this protein. A total of 83 Jumonji Domain Containing 5 products are currently listed.
Synonyms:
3110005O21Rik, Jmjd5, RGD1304823, zgc:91962, zgc:173863
list all proteins Gene Name GeneID UniProt
JMJD5 79831 Q8N371
JMJD5 77035 Q9CXT6
JMJD5 308976 Q497B8

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Jumonji Domain Containing 5 Proteins (JMJD5) by Origin

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Human Jumonji Domain Containing 5 (JMJD5) interaction partners

  1. JMJD5 depletion increases the susceptibility of cancer cells to microtubule-destabilizing agents.

  2. JMJD5 is a tumor suppressor gene in HCC (show FAM126A Proteins) pathogenesis, and the epigenetic silencing of JMJD5 promotes HCC (show FAM126A Proteins) cell proliferation by directly down-regulating CDKN1A transcription.

  3. Data suggest that JMJD5 partially accumulates on mitotic spindles during mitosis; depletion of JMJD5 results in significant mitotic arrest, spindle assembly defects, and sustained activation of spindle assembly checkpoint.

  4. These results suggest that direct interaction of JMJD5 with HBx facilitates hepatitis B virus replication through the hydroxylase activity of JMJD5.

  5. Suggest JMJD5 as a potential oncogene (show RAB1A Proteins) in colon carcinogenesis.

  6. results reveal that JMJD5 is a novel binding partner of p53 (show TP53 Proteins) and it functions as a positive modulator of cell cycle and cell proliferation mainly through the repression of p53 (show TP53 Proteins) pathway.

  7. we provide genetic and biochemical evidence that the JMJD5/CDKN1A (p21 (show CDKN1A Proteins)) axis is essential to maintaining the short G1 phase which is critical for pluripotency in human embryonic stem cells

  8. RCCD1 and KDM8 form a histone demethylase (show MBD2 Proteins) complex.

  9. These results reveal that the N-terminal domain is essential for the nuclear localization of JMJD5 and its normal enzymatic function towards substrates in the nucleus

  10. Comparison of the structure of JMJD5 with that of FIH (show CASR Proteins), a well characterized protein hydroxylase, reveals that human JMJD5 might function as a protein hydroxylase.

Mouse (Murine) Jumonji Domain Containing 5 (JMJD5) interaction partners

  1. Jmjd5 is involved in the transcriptional regulation of a subset of p53 (show TP53 Proteins)-regulated genes, possibly through the control of p53 (show TP53 Proteins) recruitment at the gene loci.

  2. Data suggest that Jmjd5 partially accumulates on mitotic spindles during mitosis; depletion of Jmjd5 results in significant mitotic arrest, spindle assembly defects, and sustained activation of spindle assembly checkpoint.

  3. Collectively, these data indicate that JMJD5 is essential during embryonal development and a repressor of p53 (show TP53 Proteins) expression. The latter suggests that JMJD5 has oncogenic activity and accordingly JMJD5 is upregulated in leukemias and breast cancer.

  4. Results suggest that Jmjd5 physiologically moderates embryonic cell proliferation through the epigenetic control of Cdkn1a (show CDKN1A Proteins) expression.

Jumonji Domain Containing 5 (JMJD5) Protein Profile

Protein Summary

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with Jumonji Domain Containing 5 (JMJD5)

  • jumonji domain containing 5 (JMJD5)
  • jumonji domain containing 5 (PTRG_02386)
  • jumonji domain containing 5 (MCYG_00400)
  • jumonji domain containing 5 (CC1G_13927)
  • jumonji domain containing 5 (PGTG_16928)
  • lysine (K)-specific demethylase 8 (kdm8)
  • jumonji domain containing 5 (KDM8)
  • lysine (K)-specific demethylase 8 (KDM8)
  • lysine (K)-specific demethylase 8 (Kdm8)
  • 3110005O21Rik protein
  • Jmjd5 protein
  • RGD1304823 protein
  • zgc:91962 protein
  • zgc:173863 protein

Protein level used designations for JMJD5

jumonji domain containing 5 , JmjC domain-containing protein 5 , Jumonji domain-containing protein 5 , lysine-specific demethylase 8 , jmjC domain-containing protein 5 , jumonji domain-containing protein 5

GENE ID SPECIES
416583 Gallus gallus
6340528 Pyrenophora tritici-repentis Pt-1C-BFP
9225437 Arthroderma otae CBS 113480
9378880 Coprinopsis cinerea okayama7130
10528643 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100158649 Xenopus (Silurana) tropicalis
608058 Canis lupus familiaris
507905 Bos taurus
79831 Homo sapiens
77035 Mus musculus
436936 Danio rerio
308976 Rattus norvegicus
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