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The balance of Cdk9 (show CDK9 Proteins) and Larp7 plays a key role in cardiomyocyte proliferation and response to injury
LARP7 knockdown induces progressive time-dependent telomere shortening concomitant with a reduction in telomerase enzymatic activity and a decrease in full-length (catalytically active) TERT (show TERT Proteins) mRNA in vitro, and that humans with LARP7 deficiency display dramatically short telomeres, borderline anemia in younger generations, and anticipation consistent with a telomeropathy.
The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, also functions as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes.
protein HEXIM (show HEXIM1 Proteins) with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE (show MEPCE Proteins) and LARP7.
results suggest that LARP7 uses both its N- and C-terminal domains to stabilize 7SK in a closed structure, which forms by joining conserved sequences at the 5'-end with the foot of the 3' hairpin and has thus functional implications
LARP7 suppresses P-TEFb (show CCNT1 Proteins) activity to inhibit breast cancer progression and metastasis.
LARP7 is most likely recruited to the HIV-1 promoter in the presence of hnRNP A1 (show HNRNPA1 Proteins).
The results demonstrate that the La modules of the human LARP7 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection.
Mediator MED23 (show MED23 Proteins) regulates basal transcription in vivo via an interaction with P-TEFb (show CCNT1 Proteins).
Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism
LARP7 downregulation occurs early during gastric tumorigenesis and may promote gastric tumorigenesis via p-TEFb (show CCNT1 Proteins) dysregulation.
LARP7 interacts with TUT1 (show TUT1 Proteins) nucleotidyl transferase to regulate Lin28 (show LIN28A Proteins) expression.
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants.
La ribonucleoprotein domain family, member 7
, la-related protein 7-like
, HDCMA18P protein
, la-related protein 7
, P-TEFb-interaction protein for 7SK stability