Browse our Lysyl Oxidase-Like 2 Proteins (LOXL2)

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Lysyl Oxidase-Like 2 Proteins (LOXL2)
On www.antibodies-online.com are 29 Lysyl Oxidase-Like 2 (LOXL2) Proteins from 9 different suppliers available. Additionally we are shipping Lysyl Oxidase-Like 2 Antibodies (108) and Lysyl Oxidase-Like 2 Kits (27) and many more products for this protein. A total of 173 Lysyl Oxidase-Like 2 products are currently listed.
Synonyms:
1110004B06Rik, 4930526G11Rik, 9430067E15Rik, CG4402, Dmel\\CG4402, dmlox-2, Dmloxl-2, GB13360, LOR2, lox2-like, loxl-2, LOXL2, WS9-14
list all proteins Gene Name GeneID UniProt
LOXL2 4017 Q9Y4K0
LOXL2 94352 P58022
LOXL2 290350 B5DF27

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Lysyl Oxidase-Like 2 Proteins (LOXL2) by Origin

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More Proteins for Lysyl Oxidase-Like 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Lysyl Oxidase-Like 2 (LOXL2) interaction partners

  1. Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development

Human Lysyl Oxidase-Like 2 (LOXL2) interaction partners

  1. LOXL2 is a potential therapeutic target against tumor progression.

  2. Insulin (show INS Proteins) resistance promotes lysyl oxidase like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.

  3. SMYD3 (show SMYD3 Proteins) enhances tumorigenicity in esophageal squamous cell carcinoma by enhancing transcription of ezrin (show EZR Proteins) and LOXL2, which are involved in proliferation, migration, and invasion.

  4. Data show that lysyl oxidase-like 2 (LOXL2) is a histone modifier enzyme that removes trimethylated lysine 4 (K4) in histone H3 (show HIST3H3 Proteins) (H3K4me3) through an amino-oxidase reaction.

  5. LOXL2 was determined to promote proliferation of hepatocellular carcinoma (HCC (show FAM126A Proteins)) and demonstrated to be highly expressed in HCC (show FAM126A Proteins) adjacent non-tumor tissue samples compared with tumor tissue samples.

  6. LOXL2 messenger RNA levels were increased in intrahepatic cholangiocarcinoma. These results were confirmed at a protein level, with a significantly higher LOXL2 immunostaining tumoral stroma. Univariate analysis revealed that LOXL2 expression was correlated with a poor overall survival and disease-free survival.

  7. glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 is a novel component of the molecular machinery that forms cross-linked collagen IV (show COL4 Proteins) networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.

  8. The expression levels of lysyl oxidase-like 2 (LOXL2) mRNA and protein were markedly suppressed in transfected prostate cancer cells with microRNAs miR (show MLXIP Proteins)-26a, miR (show MLXIP Proteins)-26b, miR (show MLXIP Proteins)-29a, miR (show MLXIP Proteins)-29b, miR (show MLXIP Proteins)-29c and miR (show MLXIP Proteins)-218.

  9. Overexpression of LOXL2 and SERPINH1 (show SERPINH1 Proteins) was observed in clinical specimens of lung cancer and fibrotic lesions. Downregulation of miR (show MLXIP Proteins)-29a caused overexpression of LOXL2 and SERPINH1 (show SERPINH1 Proteins) in lung cancer and IPF, suggesting that these genes are involved in the pathogenesis of these two diseases.

  10. LOXL2 expression is significantly upregulated in human masticatory mucosa during wound healing

Mouse (Murine) Lysyl Oxidase-Like 2 (LOXL2) interaction partners

  1. Insulin (show INS Proteins) resistance promotes lysyl oxidase like 2 (show LOXL3 Proteins) induction and fibrosis accumulation in non-alcoholic fatty liver disease.

  2. glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 (show LOXL3 Proteins) is a novel component of the molecular machinery that forms cross-linked collagen IV (show COL4 Proteins) networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.

  3. LOX (show LOX Proteins) and LOXL2 (show LOXL3 Proteins) may play an important role in the pathogenesis of AMD (show AMD1 Proteins). Targeting LOXL2 (show LOXL3 Proteins) could have a broader efficacy than targeting LOX (show LOX Proteins), by reducing angiogenesis and inflammation, as well as fibrosis.

  4. Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (show LOXL3 Proteins) and E47 (show TCF3 Proteins) in tumor growth and their requirement for lung metastasis.

  5. Findings reveal new insight into the mechanisms of fibroblast activation, a novel function of LOXL2 (show LOXL3 Proteins), and further highlight the importance of generating LOXL2 (show LOXL3 Proteins)-targeted therapies for the prevention of tumor progression and metastasis.

  6. The Snail1 (show SNAI1 Proteins) transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2 (show LOXL3 Proteins).

  7. The enzymatic activity of lysyl oxidas-like-2 (LOXL2 (show LOXL3 Proteins)) is not required for LOXL2 (show LOXL3 Proteins)-induced inhibition of keratinocyte differentiation.

  8. This study provides the first evidence for the role of LOXL2 (show LOXL3 Proteins) in regulating angiogenesis through collagen IV (show COL4 Proteins) scaffolding.

  9. LOXL2 (show LOXL3 Proteins) promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation

  10. The efficacy and safety of LOXL2 (show LOXL3 Proteins)-specific monoclonal antibody represents a new therapeutic approach with broad applicability in oncologic and fibrotic diseases.

Lysyl Oxidase-Like 2 (LOXL2) Protein Profile

Protein Summary

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Alternative names and synonyms associated with Lysyl Oxidase-Like 2 (LOXL2)

  • lysyl oxidase-like 2 (lox2)
  • lysyl oxidase-like 2 (LOXL2)
  • lysyl oxidase-like 2 (loxl2)
  • lysyl oxidase-like 2 (Loxl2)
  • 1110004B06Rik protein
  • 4930526G11Rik protein
  • 9430067E15Rik protein
  • CG4402 protein
  • Dmel\\CG4402 protein
  • dmlox-2 protein
  • Dmloxl-2 protein
  • GB13360 protein
  • LOR2 protein
  • lox2-like protein
  • loxl-2 protein
  • LOXL2 protein
  • WS9-14 protein

Protein level used designations for Lysyl Oxidase-Like 2 Proteins (LOXL2)

CG4402-PA , lox2-PA , lysyl oxidase-like 2 , Lysyl oxidase-like protein 2 , lysyl oxidase homolog 2 , lysyl oxidase homolog 2-like , lysyl oxidase related 2 , lysyl oxidase-like protein 2 , lysyl oxidase-related protein 2 , lysyl oxidase-related protein WS9-14 , Lysyl oxidase homolog 2

GENE ID SPECIES
37485 Drosophila melanogaster
408544 Apis mellifera
585092 Strongylocentrotus purpuratus
100158339 Xenopus laevis
100216062 Xenopus (Silurana) tropicalis
100413360 Callithrix jacchus
464053 Pan troglodytes
710151 Macaca mulatta
100543026 Meleagris gallopavo
4017 Homo sapiens
419533 Gallus gallus
486118 Canis lupus familiaris
532684 Bos taurus
94352 Mus musculus
290350 Rattus norvegicus
100171427 Pongo abelii
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