Browse our MBD2 Proteins (MBD2)

Full name:
Methyl-CpG Binding Domain Protein 2 Proteins (MBD2)
On www.antibodies-online.com are 3 Methyl-CpG Binding Domain Protein 2 (MBD2) Proteins from 2 different suppliers available. Additionally we are shipping MBD2 Antibodies (125) and MBD2 Kits (1) and many more products for this protein. A total of 135 MBD2 products are currently listed.
Synonyms:
DMTase, MBD2, MBD2a, NY-CO-41, wu:fa97f06, zgc:111862
list all proteins Gene Name GeneID UniProt
MBD2 8932 Q9UBB5
MBD2 17191 Q9Z2E1
Rat MBD2 MBD2 680172  

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MBD2 Proteins (MBD2) by Origin

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More Proteins for MBD2 Interaction Partners

Human Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

  1. CpG and methylation-dependent DNA binding and dynamics of the MBD2 (show DPEP2 Proteins) protein at the single-molecule level have been reported.

  2. Results show that MBD2 (show DPEP2 Proteins) mediates epigenetic silencing of Htra1 (show HTRA1 Proteins).

  3. MBD2 (show DPEP2 Proteins) has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.

  4. MBD2 (show DPEP2 Proteins) expression was elevated in HCC (show FAM126A Proteins) tissue, which suggesting MBD2 (show DPEP2 Proteins) as a candidate prognostic marker of HCC (show FAM126A Proteins).

  5. downregulation of miR (show MLXIP Proteins)-221 inhibits cell migration and invasion at least partially through targeting MBD2 (show DPEP2 Proteins) in the human OSCC cell line UM1.

  6. Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 Proteins) domain and MBD2 (show DPEP2 Proteins) C-terminus.

  7. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  8. The dynamics of MBD2 (show DPEP2 Proteins) deposition across methylated DNA regions was associated with the oncogenic transformation of human mammary cells.

  9. Data suggest that MBD2 (show DPEP2 Proteins) binds primarily at highly methylated regions, with a strong preference for CpG islands and highlights that MBD2 (show DPEP2 Proteins) binding sites display increased methylation in primary breast cancer tissues as compared to normal mammary cells.

  10. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 (show DPEP2 Proteins) for methylated DNA.

Mouse (Murine) Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

  1. MBD2 has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.

  2. Loss of Mbd2 resulted in impaired implementation of above DNA methylation (show HELLS Proteins) changes associated with altered energy homeostasis, which then protected mice from HFD-induced obesity and insulin (show INS Proteins) resistance.

  3. Mbd2 has a key role regulating expression of a range of genes that are associated with optimal dendritic cell activation and function.

  4. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  5. methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx (show HLX Proteins).

  6. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA.

  7. miR (show MLXIP Proteins)-290/371-Mbd2-Myc (show MYC Proteins) circuit regulates glycolytic metabolism to promote pluripotency.

  8. these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a (show SCN3A Proteins) expression during postnatal development and seizure condition.

  9. Data suggest that methyl-CpG binding domain protein 2 (MBD2) gene knockout may lead to accumulation of more deposits on the Bruch's membrane (BM) and influence the pathogenesis of age-related macular degeneration (AMD (show AMD1 Proteins)).

  10. In metastatic colorectal cancer cells, reduced levels of miR (show MLXIP Proteins)-221* and miR (show MLXIP Proteins)-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin (show SERPINB5 Proteins).

MBD2 Protein Profile

Protein Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MBD2

  • methyl-CpG binding domain protein 2 (MBD2)
  • methyl-CpG binding domain protein 2 (LOC100345590)
  • methyl-CpG binding domain protein 2 (Mbd2)
  • methyl-CpG binding domain protein 2 (mbd2)
  • DMTase protein
  • MBD2 protein
  • MBD2a protein
  • NY-CO-41 protein
  • wu:fa97f06 protein
  • zgc:111862 protein

Protein level used designations for MBD2

methyl-CpG binding domain protein 2 , demethylase , methyl-CpG-binding domain protein 2 , methyl-CpG-binding protein MBD2 , methyl-CpG binding protein MBD2

GENE ID SPECIES
455427 Pan troglodytes
100345590 Oryctolagus cuniculus
693801 Macaca mulatta
8932 Homo sapiens
17191 Mus musculus
337105 Danio rerio
399118 Xenopus laevis
497269 Gallus gallus
483975 Canis lupus familiaris
100337206 Bos taurus
680172 Rattus norvegicus
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