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An important role of PSIP1 in triple negative breast cancer tumorigenicity by promoting the expression of genes that control the cell cycle and tumor metastasis
We identify the Myc (show MYC Proteins)-interacting protein JPO2 (show CDCA7L Proteins) and its partner binding protein LEDGF/p75 as critical modulators of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling and metastasis in medulloblastoma
The association of LEDGF proteins with the FACT complex and give further support to a role of SSRP1 (show SSRP1 Proteins) in HIV-1 infection.
short isoform (p52 (show FKBP4 Proteins)) of a transcriptional co-activator-PC4 (show IFRD1 Proteins) and SF2 (show SRSF1 Proteins) interacting protein (Psip1), which is known to be involved in linking transcription to RNA processing, specifically regulates the expression of the lncRNA Hottip-located at the 5' end of the Hoxa locus
Germline polymorphisms in an enhancer of PSIP1 are associated with epithelial ovarian cancer.
PSIP1 likely plays an important role in Hereditary Hearing Loss.
LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced (show SQSTM1 Proteins) Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 (show PDIA3 Proteins) in Prostate Cancer
common LEDGF/p75 interaction interface shared by JPO2 (show CDCA7L Proteins), PogZ (show POGZ Proteins), MLL1, IWS1 and HIV IN
Results show that these antibodies are highly specific for dense fine speckles 70 protein DFS70/LEDGFp75 and do not target methyl CpG binding protein 2 (MeCP2).
LEDGF/p75 interacts with splicing factors, contributes to exon choice, and directs HIV-1 integration to transcription units that are highly spliced.
The role of Psip1 in cardiac development
conclude that small peptides disrupting the LEDGF/p75-MLL (show MLL Proteins) interface have selective anti-leukemic activity providing a direct rationale for the design of small molecule inhibitors targeting this interaction
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.
Alcohol (ADH (show AVP Proteins)) and ALDH (show ALDH3A1 Proteins) dehydrogenases are implicated in cellular detoxification and conversion of vitamin A to RA. Lens epithelium-derived growth factor provides cellular protection against stress by transactivating stress-associated genes.
Results suggest that TNF-alpha (show TNF Proteins) elevates the expression of lens epithelium-derived growth factor (LEDGF) and that LEDGF is one of the transactivators of gamma-glutamylcysteine synthetase heavy subunit (show GCLC Proteins) gene.
These suggest a role for Psip1 in the control of Homeobox (show PRRX1 Proteins) expression and may also explain why PSIP1 (LEDGF) is found as a fusion partner with NUP98 (show NUP98 Proteins) in myeloid leukemias.
some DFS70-positive sera have antibodies that recognize antigens of the lens
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).
PC4 and SFRS1 interacting protein 1
, PC4 and SFRS1-interacting protein
, PC4 and SFRS1-interacting protein-like protein
, Lens epithelium-derived growth factor
, PC4 and SFRS1-interacting protein-like
, putative LEDGF/p75 transcription factor
, lens epithelium-derived growth factor
, CLL-associated antigen KW-7
, DFS 70
, dense fine speckles 70 kDa protein
, transcriptional coactivator p52/p75
, transcriptional coactivator p75/p52
, PC4 and SFRS1 interacting protein 2
, dense fine speckles 70
, supercoiled DNA binding protein 75
, lens epithelium derived growth factor p75
, transcription coactivator p75