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Browse our FCN1 Proteins (FCN1)

Full name:
Ficolin (Collagen/fibrinogen Domain Containing) 1 Proteins (FCN1)
On are 13 Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) Proteins from 7 different suppliers available. Additionally we are shipping FCN1 Antibodies (84) and FCN1 Kits (29) and many more products for this protein. A total of 139 FCN1 products are currently listed.
Fcn1, FCN2, Fcna, FCNB, FCNM
list all proteins Gene Name GeneID UniProt
FCN1 2219 O00602
FCN1 83517  
FCN1 14133 O70165

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FCN1 Proteins (FCN1) by Origin

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Top referenced FCN1 Proteins

  1. Human FCN1 Protein expressed in Human Cells - ABIN2003613 : Endo, Liu, Kanno, Takahashi, Matsushita, Fujita: Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins. in Genomics 2004 (PubMed)
    Show all 3 references for ABIN2003613

More Proteins for FCN1 Interaction Partners

Human Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) interaction partners

  1. Data indicate differences in the plasma concentrations of collectin liver 1 (show COLEC10 Proteins) and collectin (show MBL2 Proteins) kidney 1 (show ZNF354A Proteins), M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls.

  2. This study aims to investigate whether an association exists between the ficolins that are part of the lectin complement pathway and systemic lupus erythematosus.

  3. the differential binding of ficolin-1 to lymphocyte subsets suggests ficolin-1 as a novel link between innate and adaptive immunity.

  4. In patients with early rheumatoid arthritis, elevated plasma M-ficolin levels correlated with a high disease activity score at baseline and 1 year. A low M-ficolin level was the strongest predictor of remission and low disease activity.

  5. Data show that a photodynamic therapy (PDT (show TWIST1 Proteins)) dose-dependent upregulation of CRP (show CRP Proteins) gene, as well as of PTX3 (show PITX3 Proteins) and ficolin 1 genes in lung tumor A549 cells, and indicate critical role played by PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/AP-1 (show FOSB Proteins) pathway.

  6. These results demonstrate that ficolin-1 and PTX3 (show PITX3 Proteins) heterocomplex formation acts as a noninflammatory "find me and eat me" signal to sequester altered-host cells.

  7. M-ficolin bound strongly to serotype 19B and 19C polysaccharides.

  8. Study interlinks the genotype and phenotype relationship concerning polymorphisms in FCN1 and corresponding concentrations and biological functions of M-ficolin.

  9. A genotype study of common promoter FCN1 single nucleotide polymorphisms (SNPs) finds evidence for opposite associations between different FCN1 haplotypes and clinical leprosy in Euro-Brazilians and Afro-Brazilians.

  10. Two polymorphisms in the promoter region of FCN1 is associated with the expression and synthesis of ficolin-1 as well as associated with decreased survival in a cohort of patient with systemic inflammatory response syndrome and sepsis.

Mouse (Murine) Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1) interaction partners

  1. FcnA-deficient and FcnA/ficolin B double-deficient mice lack FcnA-mediated complement activation in the sera, because of absence of complexes comprising FcnA and MBL-associated serine proteases.

  2. the binding properties of the murine serum ficolin-A towards a panel of different clinical relevant microorganisms

  3. binds to the glycoproteins hemagglutinin (show HA Proteins) and neuraminidase (show NEU Proteins) and inhibits influenza A virus infection both in vitro and in vivo

  4. Recombinant mouse ficolin A, mannose-binding lectin-A, and mannose-binding lectin-C bound to fibrinogen in a dose-dependent manner. The lectin pathway, through mannose-binding lectins, synchronized with blood coagulation.

  5. the expression pattern of ficolin A expression was closely similar to that of mannose-binding lectin-associated serine proteases, suggesting that these molecules may function in coordination as components of the lectin complement pathway

  6. Ficolin A protein (smapshowed a potent complement activating capacity.These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway.

  7. A functionally relevant signal peptide of ficolin A was identified by using mass spectrometry analysis to determine the N-terminal sequence of secreted ficolin A.

FCN1 Protein Profile

Protein Summary

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.

Alternative names and synonyms associated with FCN1

  • ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) (FCN2)
  • ficolin (collagen/fibrinogen domain containing) 1 (FCN1)
  • ficolin (collagen/fibrinogen domain containing) 1 (Fcn1)
  • ficolin A (Fcna)
  • Fcn1 protein
  • FCN2 protein
  • Fcna protein
  • FCNB protein
  • FCNM protein

Protein level used designations for FCN1

ficolin 1 , M-ficolin , collagen/fibrinogen domain-containing protein 1 , ficolin (collagen/fibrinogen domain-containing) 1 , ficolin-1 , ficolin-A , ficolin-alpha , ficolin B , L-ficolin , collagen/fibrinogen domain-containing protein 2 , ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) , ficolin 2 , ficolin-2 , ficolin-B , ficolin-beta , ficolin A

417298 Gallus gallus
2219 Homo sapiens
397316 Sus scrofa
497016 Bos taurus
83517 Rattus norvegicus
100724936 Cavia porcellus
14133 Mus musculus
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