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anti-Mouse (Murine) MBL2 antibody for Immunohistochemistry (Frozen Sections)

Recommended MBL2 Antibody (supplied by: Log in to see )

Antigen
Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) Antibodies
  • Ab2-001
  • Ab2-011
  • cMBl
  • COLEC1
  • collectin
  • HSMBPC
  • L-MBP
  • MBL
  • MBL-C
  • MBL1
  • mbl2
  • MBL2D
  • MBP
  • MBP-C
  • MBP1
  • MBPD
  • pMBP-27
Reactivity
Mouse (Murine)
94
19
12
4
2
2
1
1
1
Host
Rat
67
37
8
3
Clonality
Monoclonal
Conjugate
This MBL2 antibody is un-conjugated
8
6
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
93
73
33
14
12
11
11
3
2
1
1
1
1
Supplier
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Catalog No. ABIN1108115
$ 566.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.000884117 ABIN1859770 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG AA 129-244 Log in to see Polyclonal
0.000884117 ABIN4332956 IA ICC IF IHC IHC (fro) WB Mouse IgG2a Log in to see 14D12
0.000884117 ABIN1862876 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG Log in to see Polyclonal

Top referenced anti-MBL2 antibody for Immunohistochemistry (Frozen Sections)

Similar anti-MBL2 Antibodies

Application / Reactivity Mouse (Murine)
ELISA 8 Antibodies
Enzyme Immunoassay (EIA) 3 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies
Immunohistochemistry (IHC) 4 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 3 Antibodies
Western Blotting (WB) 17 Antibodies

General

Antigen Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) Antibodies
Reactivity Mouse (Murine)
(94), (19), (12), (4), (2), (2), (1), (1), (1)
Host Rat
(67), (37), (8), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This MBL2 antibody is un-conjugated
(8), (6), (2), (2), (2), (2)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(93), (73), (33), (14), (12), (11), (11), (3), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-MBL2 Antibody

Target Details MBL2 Application Details Handling References for anti-MBL2 Antibody (ABIN1108115) Images
Cross-Reactivity (Details) Species reactivity (tested):Mouse
Purification Protein G
Immunogen Purified MBL-C
Clone 14D12
Isotype IgG2a

Target Details MBL2

Product Details anti-MBL2 Antibody Application Details Handling References for anti-MBL2 Antibody (ABIN1108115) Images back to top
Antigen
Alternative Name Mannan Binding Protein (MBL2 Antibody Abstract)
Background Mannose binding lectin (MBL), also called mannose- or mannan-binding protein (MBP), is a member of the group of collectins. MBL is an important pattern-recognition receptor in the innate immune system. The protein mediates innate immune responses, such as activation of the complement lectin pathway and phagocytosis, to help fight infections. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. Binding of MBL leads to the activation of MBL-associated serine proteases (MASP's). Activated MASP-2 cleaves C4 and C2 in a similar way as C1s do for the classical pathway (CP) leading to the formation of C4b2a, cleavage of the classical pathway convertase C3, and eventually complement activation up to the formation of the membrane attack complex. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. MBL is predominantly synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A.Synonyms: MBL, MBL2, MBP, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C
Gene ID 17195
NCBI Accession NP_034906
UniProt P41317
Research Area Complement Factors, Receptors, Serum/Plasma Proteins, Inflammation
Pathways Complement System

Application Details

Product Details anti-MBL2 Antibody Target Details MBL2 Handling References for anti-MBL2 Antibody (ABIN1108115) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-MBL2 Antibody Target Details MBL2 Application Details References for anti-MBL2 Antibody (ABIN1108115) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.

References for anti-MBL2 Antibody (ABIN1108115)

Product Details anti-MBL2 Antibody Target Details MBL2 Application Details Handling Images back to top
Background publications

Pumidonming, Walochnik, Dauber, Petry: "Binding to complement factors and activation of the alternative pathway by Acanthamoeba." in: Immunobiology, Vol. 216, Issue 1-2, pp. 225-33, 2010

Matthijsen, de Winther, Kuipers, van der Made, Weber, Herias, Gijbels, Buurman: "Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice." in: Circulation, Vol. 119, Issue 16, pp. 2188-95, 2009

Held, Thiel, Loos, Petry: "Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans." in: Molecular immunology, Vol. 45, Issue 15, pp. 3934-41, 2008

Phaneuf, Lillie, Hayes, Turner: "Binding of mouse mannan-binding lectins to different bacterial pathogens of mice." in: Veterinary immunology and immunopathology, Vol. 118, Issue 1-2, pp. 129-33, 2007

Liu, Jensen, Hansen, Petersen, Takahashi, Ezekowitz, Hansen, Jensenius, Thiel: "Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses." in: Scandinavian journal of immunology, Vol. 53, Issue 5, pp. 489-97, 2001

Images

Product Details anti-MBL2 Antibody Target Details MBL2 Application Details Handling References for anti-MBL2 Antibody (ABIN1108115) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-MBL2 antibody (Mannose-Binding Lectin (Protein C) 2, Soluble) (ABIN1108115) anti-Mannose-Binding Lectin (Protein C) 2, Soluble (MBL2) antibody