Browse our Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member 4 Proteins (SLC1A4)

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Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member 4 Proteins (SLC1A4)
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Synonyms:
ASCT-1, ASCT1, AW045657, SATT, si:zc101n13.5, zgc:92817
list all proteins Gene Name GeneID UniProt
SLC1A4 6509 P43007
SLC1A4 55963 O35874
Rat SLC1A4 SLC1A4 305540  

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More Proteins for Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member 4 Interaction Partners

Human Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member 4 (SLC1A4) interaction partners

  1. ANKRD50 simultaneously engages multiple parts of the SNX27 (show SNX27 Proteins)-retromer-WASH complex machinery in a direct and co-operative interaction network that is needed to efficiently recycle the nutrient transporters

  2. SLC1A4 deficiency should not be considered a population-specific disorder, and all patients with unexplained severe neurodevelopmental delay and the features outlined should be investigated regardless of ethnicity, as there are no known metabolic markers of this potentially treatable condition.

  3. SLC1A4 is the disease causing gene of a novel neurologic disorder manifesting with significant intellectual disability, severe postnatal microcephaly, spasticity and thin corpus callosum.

  4. ASCT1 is essential in brain serine transport.

  5. SLC1A4 disruption may impair brain development and function by decreasing the levels of L-serine in neurons. The identification of additional families with mutations in SLC1A4 would be necessary to confirm its involvement in intellectual disability.

  6. Na+ interactions with the neutral amino acid transporter ASCT1.

  7. ASCT1 is able to mediate a concentrative transport of alanine, which is Na+-dependent but not coupled to the Na+ gradient

  8. used as receptor by HERV-W Env glycoprotein (show ERVW-1 Proteins)

  9. results strongly suggest that combinations of amino acid sequence changes and N-linked oligosaccharides in a critical carboxyl-terminal region of extracellular loop 2 (ECL2) control retroviral utilization of both the ASCT1 and ASCT2 (show SLC1A5 Proteins) receptors

  10. This study revealed genetic associations of SLC1A4, SQSTM1 (show SQSTM1 Proteins), and EIF4EBP1 (show EIF4EBP1 Proteins) with MSA (show TPO Proteins). These results may lend genetic support to the hypothesis that oxidative stress is associated with the pathogenesis of MSA (show TPO Proteins).

Mouse (Murine) Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member 4 (SLC1A4) interaction partners

  1. used as receptor by HERV-W Env glycoprotein (show ERVW-1 Proteins) when their sites for N-glycosylation are eliminated by mutagenesis

  2. ASCT1 expression was gradually downregulated in neuronal populations during late embryonic and neonatal periods, whereas its high expression was transmitted to radial glial cells and then to astrocytes; ASCT1 appears regulated to meet metabolic demands

  3. results strongly suggest that combinations of amino acid sequence changes and N-linked oligosaccharides in a critical carboxyl-terminal region of extracellular loop 2 (ECL2) control retroviral utilization of both the ASCT1 and ASCT2 (show SLC1A5 Proteins) receptors

  4. either Phgdh (show PHGDH Proteins) or ASCT1 is provided to each segment of renal tubules, suggesting that metabolic interplay mediated by L-serine biosynthesis and supply may exist in the kidney

  5. Results demonstrate injury-induced changes in Phgdh (show PHGDH Proteins) and ASCT1 expression.

Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member 4 (SLC1A4) Protein Profile

Protein Summary

Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.

Alternative names and synonyms associated with Solute Carrier Family 1 (Glutamate/Neutral Amino Acid Transporter), Member 4 (SLC1A4)

  • solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (SLC1A4)
  • solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (slc1a4)
  • solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (Slc1a4)
  • ASCT-1 protein
  • ASCT1 protein
  • AW045657 protein
  • SATT protein
  • si:zc101n13.5 protein
  • zgc:92817 protein

Protein level used designations for SLC1A4

solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 , solute carrier family 1, member 4 , neutral amino acid transporter A-like , neutral amino acid transporter A , ASCT-1 , alanine/serine/cysteine/threonine transporter 1 , glutamate/neutral amino acid transporter , solute carrier family 1 member 4 , SATT , neutral amino acid transporter ASCT1

GENE ID SPECIES
459278 Pan troglodytes
481391 Canis lupus familiaris
693400 Macaca mulatta
100124992 Xenopus (Silurana) tropicalis
100397568 Callithrix jacchus
100447643 Pongo abelii
100587032 Nomascus leucogenys
368885 Danio rerio
769612 Gallus gallus
6509 Homo sapiens
326577 Bos taurus
55963 Mus musculus
305540 Rattus norvegicus
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