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Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR (show CFTR ELISA Kits), are associated with human asthenozoospermia.
SLC26A8 mutations are not a common cause of male infertility.
structural defects in sperm are not caused by abnormal transcription or point mutations of the TAT1 and SEPT4 (show SEPT4 ELISA Kits) genes; however, although both proteins are expressed, they are not properly localized at sperm annulus
Tat1 (Slc26A8) is a critical component of the sperm annulus that is essential for proper sperm tail differentiation and motility
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described.
solute carrier family 26, member 8
, testis anion transporter 1-like
, anion exchange transporter
, anion transporter/exchanger-8
, testis anion transporter 1
, solute carrier family 26 member 8