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Browse our BARD1 Proteins (BARD1)

Full name:
BRCA1 Associated RING Domain 1 Proteins (BARD1)
On www.antibodies-online.com are 4 BRCA1 Associated RING Domain 1 (BARD1) Proteins from 3 different suppliers available. Additionally we are shipping BARD1 Antibodies (83) and BARD1 Kits (4) and many more products for this protein. A total of 94 BARD1 products are currently listed.
Synonyms:
BARD1, ENSMUSG00000060893, ENSMUSG00000073653, LOC100147913
list all proteins Gene Name GeneID UniProt
BARD1 580 Q99728
BARD1 12021 O70445
BARD1 64557 Q9QZH2

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BARD1 Proteins (BARD1) by Origin

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More Proteins for BARD1 Interaction Partners

Human BRCA1 Associated RING Domain 1 (BARD1) interaction partners

  1. Study presents four different pathogenic BARD1 variants identified in ovarian cancer patients. Three of them result in incorrect splicing of the corresponding exons, which may prompt expression of specific BARD1 isoforms and carcinogenesis.

  2. Suggest BARD1 as a driver of proliferation and of pulmonary fibrosis pathogenesis.

  3. a role for the BRCT domain in stimulating BARD1 nuclear export and mitochondrial localization, and in assembling mitochondrial BARD1/p53 (show TP53 Proteins) complexes to regulate specific activities such as apoptotic function.

  4. Mutations do not contribute substantially (>> 10% of the total BARD1 mutations) to BARD1 sequence variation and, subsequently, to familial breast and/or ovarian cancer aggregation.

  5. BARD1 interacts with H3K9me2 through HP1 (show DEFA1 Proteins) and plays a critical role in retention of a BRCA1/BARD1 complex at the site of DNA damage.

  6. FOXK2 (show FOXK2 Proteins) might act as a negative regulator of ERalpha (show ESR1 Proteins), and its association with both ERalpha (show ESR1 Proteins) and BRCA1/BARD1 could lead to the down-regulation of ERalpha (show ESR1 Proteins) transcriptional activity, effectively regulating the function of ERalpha (show ESR1 Proteins).

  7. Increased expression of the BARD1 protein, with its ubiquitin ligase function, was associated with significantly improved overall and disease-free survival, which has yet to be documented for ACC.

  8. BARD1 long non-coding RNA is overexpressed in neoplasms.

  9. HDACi (histone deacetylase (show HDAC1 Proteins) inhibitor) Vorinostat reduces BARD1 mRNA levels by increasing miR (show MLXIP Proteins)-19a and miR (show MLXIP Proteins)-19b expression levels.

  10. BARD1 is frequently overexpressed in brain metastases from breast cancer and may constitute a mechanism to overcome reactive oxygen species-mediated genotoxic stress in the metastatic brain.

Mouse (Murine) BRCA1 Associated RING Domain 1 (BARD1) interaction partners

  1. Suggest BARD1 as a driver of proliferation and of pulmonary fibrosis pathogenesis.

  2. identification of BARD1 as mediator between proapoptotic stress and p53 (show TP53 Proteins)-dependent apoptosis

  3. the developmental functions of Brca1 (show BRCA1 Proteins) and Bard1 are mediated by the Brca1 (show BRCA1 Proteins)/Bard1 heterodimer.

  4. Data show that expression of truncated mouse or human BARD1 peptides capable of interacting with Brca1 results in a homologous-repair deficiency.

  5. the ankyrin and BRCT motifs of BARD1 are each essential for both chromosome stability and homology-directed DNA repair.

  6. The remarkable similarities between the mammary carcinomas of Bard1-, Brca1 (show BRCA1 Proteins)-, and Bard1/Brca1 (show BRCA1 Proteins)-mutant mice indicate that the tumor suppressor activities of both genes are mediated through the BRCA1 (show BRCA1 Proteins)/BARD1 heterodimer.

BARD1 Protein Profile

Protein Summary

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

Alternative names and synonyms associated with BARD1

  • BRCA1 associated RING domain 1 (BARD1)
  • novel protein similar to vertebrate BRCA1 associated RING domain 1 (BARD1) (CH211-207D8.3)
  • BRCA1 associated RING domain 1 (LOC100229796)
  • BRCA1 associated RING domain 1 (bard1)
  • BRCA1 associated RING domain 1 (Bard1)
  • BARD1 protein
  • ENSMUSG00000060893 protein
  • ENSMUSG00000073653 protein
  • LOC100147913 protein

Protein level used designations for BARD1

BRCA1 associated RING domain 1 , BRCA1-associated RING domain protein 1-like , BRCA1 associated RING domain 1 isoform alfa , BRCA1 associated RING domain 1 isoform beta , BRCA1 associated RING domain 1 isoform delta , BRCA1 associated RING domain 1 isoform epsilon , BRCA1 associated RING domain 1 isoform eta , BRCA1 associated RING domain 1 isoform gamma , BRCA1 associated RING domain 1 isoform phi , BRCA1-associated RING domain gene 1 , BRCA1-associated RING domain protein 1 , BARD-1

GENE ID SPECIES
100053962 Equus caballus
470638 Pan troglodytes
694301 Macaca mulatta
100147913 Danio rerio
100229796 Taeniopygia guttata
100405252 Callithrix jacchus
100447274 Pongo abelii
100471907 Ailuropoda melanoleuca
100538376 Meleagris gallopavo
100563125 Anolis carolinensis
100600973 Nomascus leucogenys
580 Homo sapiens
424010 Gallus gallus
610190 Canis lupus familiaris
100156005 Sus scrofa
530961 Bos taurus
12021 Mus musculus
64557 Rattus norvegicus
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