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Browse our anti-MCM4 (MCM4) Antibodies

Full name:
anti-Minichromosome Maintenance Deficient 4 Antibodies (MCM4)
On www.antibodies-online.com are 108 Minichromosome Maintenance Deficient 4 (MCM4) Antibodies from 20 different suppliers available. Additionally we are shipping MCM4 Proteins (6) and MCM4 Kits (5) and many more products for this protein. A total of 134 MCM4 products are currently listed.
Synonyms:
19G, AI325074, AU045576, cb1025, Cdc21, CDC54, fc12c09, fj85g09, hCdc21, hm:zeh1616, mcdc21, Mcmd4, mKIAA4003, NKCD, NKGCD, P1-CDC21, wu:fc12c09, wu:fj85g09, zeh1616
list all antibodies Gene Name GeneID UniProt
MCM4 4173 P33991
MCM4 29728  
MCM4 17217 P49717

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anti-Human MCM4 Antibodies:

anti-Rat (Rattus) MCM4 Antibodies:

anti-Mouse (Murine) MCM4 Antibodies:

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Top referenced anti-MCM4 Antibodies

  1. Human Polyclonal MCM4 Primary Antibody for WB - ABIN967643 : Coxon, Maundrell, Kearsey: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication. in Nucleic acids research 1993 (PubMed)
    Show all 5 references for ABIN967643

  2. Chicken Polyclonal MCM4 Primary Antibody for WB - ABIN2774884 : Ishimi, Komamura-Kohno, Kwon, Yamada, Nakanishi: Identification of MCM4 as a target of the DNA replication block checkpoint system. in The Journal of biological chemistry 2003 (PubMed)

More Antibodies against MCM4 Interaction Partners

Human Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

  1. We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin

  2. Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase (show DNAH8 Antibodies) activities to the complex containing wild-type MCM4

  3. Mutant p53 (show TP53 Antibodies) depletion profoundly influenced PARP1 (show PARP1 Antibodies) localization and increased the level of PCNA (show PCNA Antibodies) and MCM4 proteins.

  4. Of the total, the deregulation of several genes (CDK1 (show CDK1 Antibodies), CDK2 (show CDK2 Antibodies), CDK4 (show CDK4 Antibodies), MCM2 (show MCM2 Antibodies), MCM3 (show MCM3 Antibodies), MCM4, EIF3a (show EIF6 Antibodies) and RPN2 (show PSMD1 Antibodies)) were potentially associated with disease development and progression.

  5. Mcm2-7 (show MCM2 Antibodies) loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.

  6. Peroxisome proliferator-activated receptor gamma (show PPARG Antibodies) coactivator 1beta (PGC-1beta (show PPARGC1B Antibodies)) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells

  7. point mutation of MCM4 perturbs proper interaction with MCM6 (show MCM6 Antibodies) to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 (show MCM2 Antibodies) complex

  8. Mutations in MCM4/PRKDC (show PRKDC Antibodies) represent a novel cause of DNA breakage and NK cell deficiency.

  9. Widdrol breaks DNA directly in HT29 cells, resulting in checkpoint activation via Chk2 (show CHEK2 Antibodies)-p53 (show TP53 Antibodies)-Cdc25A (show CDC25A Antibodies)-p21 (show CDKN1A Antibodies)-MCM4 pathway and finally cells go to G1-phase cell cycle arrest and apoptosis.

  10. partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency

Mouse (Murine) Minichromosome Maintenance Deficient 4 (MCM4) interaction partners

  1. Together, these data support a model in which chromosomal abnormalities in Sdl mice result from the ability of MCM4(D573H) to incorporate into MCM complexes and render them inactive.

  2. Peroxisome proliferator-activated receptor gamma (show PPARG Antibodies) coactivator 1beta (PGC-1beta (show PPARGC1B Antibodies)) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells

  3. partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency

  4. MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency

  5. role of subunits in DNA helicase acdtivity

  6. Substrate preference and helicase (show DNA2 Antibodies) actions of mouse MCM4/6/7 helicase (show DNA2 Antibodies) complexes.

  7. MCM4 phosphorylation by Cdc7 (show CDC7 Antibodies) kinase facilitates its interaction with Cdc45 (show CDC45 Antibodies) on chromatin

  8. Hypomorphic alleles of Mcm4 may increase breast cancer risk.

  9. Loss of one allele of cdc2l (show CDK13 Antibodies) genefacilitates carcinogen-induced skin carcinogenesis in vivo.

  10. Mcm4(Chaos3) mutation appears to destabilize the MCM2-7 (show MCM2 Antibodies) complex, causing impaired DNA replication and may have a causative role in cancer development.

MCM4 Antigen Profile

Antigen Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Alternative names and synonyms associated with MCM4

  • minichromosome maintenance complex component 4 (mcm4) antibody
  • MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) (mcm4) antibody
  • minichromosome maintenance complex component 4 (MCM4) antibody
  • minichromosome maintenance complex component 4 (Mcm4) antibody
  • minichromosome maintenance deficient 4 homolog (S. cerevisiae) (Mcm4) antibody
  • 19G antibody
  • AI325074 antibody
  • AU045576 antibody
  • cb1025 antibody
  • Cdc21 antibody
  • CDC54 antibody
  • fc12c09 antibody
  • fj85g09 antibody
  • hCdc21 antibody
  • hm:zeh1616 antibody
  • mcdc21 antibody
  • Mcmd4 antibody
  • mKIAA4003 antibody
  • NKCD antibody
  • NKGCD antibody
  • P1-CDC21 antibody
  • wu:fc12c09 antibody
  • wu:fj85g09 antibody
  • zeh1616 antibody

Protein level used designations for MCM4

DNA replication licensing factor mcm4 , MCM4 minichromosome maintenance deficient 4 , minichromosome maintenance protein 4 , DNA replication licensing factor MCM4 , CDC21 homolog , homolog of S. pombe cell devision cycle 21 , minichromosome maintenance deficient 4 , mini chromosome maintenance deficient 4 homolog , minichromosome maintenance deficient 4 homolog , P1-CDC21

GENE ID SPECIES
448137 Xenopus (Silurana) tropicalis
337598 Danio rerio
4173 Homo sapiens
426764 Gallus gallus
477871 Canis lupus familiaris
504367 Bos taurus
29728 Rattus norvegicus
17217 Mus musculus
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