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MCM2 (show MCM2 ELISA Kits)-MCM6 complex is required for CHK2 (show CHEK2 ELISA Kits) chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.
This MCM4 (show MCM4 ELISA Kits) mutation affected human MCM4 (show MCM4 ELISA Kits)/6/7 complex formation, since the complex containing the mutant MCM4 (show MCM4 ELISA Kits) protein is unstable and the mutant MCM4 (show MCM4 ELISA Kits) protein is tend to be degraded.
knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei.
Methyl(R217)HuR (show ELAVL1 ELISA Kits) and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma
Purified MCM4 (show MCM4 ELISA Kits)/6/7 complex containing the G364R MCM4 (show MCM4 ELISA Kits) exhibited similar levels of single-stranded DNA binding and ATPase (show DNAH8 ELISA Kits) activities to the complex containing wild-type MCM4 (show MCM4 ELISA Kits)
Report presence of homozygous--13910CC genetic variant in the MCM-6 gene upstream from the lactase (show LCT ELISA Kits) gene in lactose intolerant patients treated with lactose-restricted diet.
Mcm2-7 (show MCM2 ELISA Kits) loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
The subtype and MCM6 protein expression in craniopharyngiomas are related to the prognosis of tumor.
the molecular mechanism of Mcm2-7 (show MCM2 ELISA Kits) chromatin loading and prereplicative complex assembly.
Data show that cells subjected to chronic hypoxia the replicative restart was inhibited along with numerous replication factors including MCM6 and RPA (show RPA1 ELISA Kits), and cells reoxygenated after acute hypoxia underwent rapid p53 (show TP53 ELISA Kits)-dependent apoptosis.
role of subunits in dna helicase activity
Substrate preference and helicase (show DNA2 ELISA Kits) actions of mouse MCM4 (show MCM4 ELISA Kits)/6/7 helicase (show DNA2 ELISA Kits) complexes.
Accumulation and dynamics of Mcm6 are described during oogenesis and the first embryonic cell cycle.
DNA binding and helicase (show DNA2 ELISA Kits) activities of Mcm4 (show MCM4 ELISA Kits)/6/7 are significantly stimulated by Cdt1 (show CDT1 ELISA Kits)
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
, female sterile(1)K1214
, minichromosome maintenance 6
, DNA replication licensing factor MCM6
, MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
, minichromosome maintenance deficient (mis5, S. pombe) 6
, minichromosome maintenance deficient 6 homolog
, intestinal DNA replication protein
, mini chromosome maintenance deficient 6
, minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
, maternal DNA replication licensing factor mcm6
, maternal minichromosome maintenance protein 6
, mis5 homolog