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Browse our MSH6 Proteins (MSH6)

Full name:
MutS Homolog 6 (E. Coli) Proteins (MSH6)
On are 4 MutS Homolog 6 (E. Coli) (MSH6) Proteins from 3 different suppliers available. Additionally we are shipping MSH6 Antibodies (124) and many more products for this protein. A total of 133 MSH6 products are currently listed.
AU044881, AW550279, cb326, GTBP, Gtmbp, HNPCC5, HSAP, LOC100227810, p160, wu:fb36c12
list all proteins Gene Name GeneID UniProt
Rat MSH6 MSH6 100360342  
MSH6 2956 P52701
MSH6 17688 P54276

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MSH6 Proteins (MSH6) by Origin

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More Proteins for MSH6 Interaction Partners

Zebrafish MutS Homolog 6 (E. Coli) (MSH6) interaction partners

  1. Studied MSH6 gene expression in developing zebrafish and the influence of MSH6 expression on the production of mismatch binding factors.

  2. Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Proteins) genes, mlh1 (show MLH1 Proteins), msh2 (show MSH2 Proteins), and msh6, in zebrafish that develop tumors at low frequencies.

Human MutS Homolog 6 (E. Coli) (MSH6) interaction partners

  1. Heterozygous germline mutations in any of the mismatch repair (MMR (show MRC1 Proteins)) genes, MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins), MSH6, and PMS2 (show PMS2 Proteins), cause Lynch syndrome (LS), an autosomal dominant cancer predisposition syndrome.

  2. MSH2 (show MSH2 Proteins), MSH6, and EXO1 (show EXO1 Proteins) genes were overexpressed in gastroesophageal cancers.

  3. SNP rs1800934 and 12 rare variants in the mismatch repair gene MSH6 were also associated with cafe-au-lait macule count in neurofibromatosis type 1 (show NF1 Proteins) patients.

  4. microsatellite instability-high and loss of MSH6 were found. Based on these results, genetic testing of MSH6 revealed a frame-shift mutation in codon 604

  5. MutSalpha, proliferating cell nuclear antigen (show PCNA Proteins), and replication factor C activate MutLalpha endonuclease to remove the 1-nucleotide Okazaki fragment flaps

  6. We describe a kindred with multiple gastrointestinal malignancies where a novel MSH6 germline susceptibility variant was identified

  7. Heterogenous MSH6 loss is uncommon, usually caused by instability in MSH6 exon 5 polycytosine tract, and not associated with germline MSH6 mutation.

  8. immunohistochemical expression of MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins), and MSH6 in initial glioblastoma is not associated with patient survival

  9. The study evaluates the frequency and distribution of mutations in the MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins) and MSH6 genes within a cohort of families with Lynch syndrome in Cyprus.

  10. Somatic rearrangements in MSH2 (show MSH2 Proteins) and MSH6 are an important mechanism leading to hypermutation and microsatellite instability in advanced prostate cancer.

Mouse (Murine) MutS Homolog 6 (E. Coli) (MSH6) interaction partners

  1. we show that AID binds cooperatively with UNG and the mismatch repair proteins Msh2-Msh6 to Ig Smu and Sgamma3 regions

  2. Data suggest that MSH6 protects B cells from neoplastic transformation by preserving genomic stability.

  3. similar defects on switching in Msh2(-/-), Msh2(-/-)Msh6(-/-) and Msh2(-/-)Msh6(-/-)Msh3(-/-) mice confirm that MutSalpha but not MutSbeta plays an important role in class switch recombination

  4. Msh6 deficiency resulted in somatic instability of a (GTG (show GGT1 Proteins))84 repeat.

  5. role for Msh6 in protective cellular responses of primary cells to ultraviolet-B-induced mutagenesis and, hence, the prevention of skin cancer.

  6. Data suggest that MutS homologues Msh2 (show MSH2 Proteins), Msh3, and Msh6 play overlapping and distinct roles during antibody diversification processes.

  7. Data suggest that activation-induced cytidine deaminase (show AICDA Proteins) has limited entry points into V and S regions in vivo, and subsequent mutation requires Msh2 (show MSH2 Proteins)-Msh6, but not Msh3, and DNA polymerase (show POLB Proteins).

  8. Mice nullizygous for both Msh2 (show MSH2 Proteins) and Msh3 and those nullizygous for both Msh3 and Msh6 displayed the greatest overall increases in mutation frequencies compared with wild-type mice.

  9. in Msh6(-/-)Ung (show UNG Proteins)(-/-) mice, mutations were mostly C,G transitions and class switch recombination was greatly reduced.

  10. p53 (show TP53 Proteins) and Msh6 are functionally interrelated and these tumor suppressors act together to accelerate tumorigenesis.

MSH6 Protein Profile

Protein Summary

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Alternative names and synonyms associated with MSH6

  • mutS homolog 6 (E. coli) (LOC100360342)
  • mutS homolog 6 (E. coli) (msh6)
  • mutS homolog 6 (E. coli) (Msh6)
  • mutS homolog 6 (E. coli) (MSH6)
  • mutS homolog 6 (E. coli) (LOC100227810)
  • AU044881 protein
  • AW550279 protein
  • cb326 protein
  • GTBP protein
  • Gtmbp protein
  • HNPCC5 protein
  • HSAP protein
  • LOC100227810 protein
  • p160 protein
  • wu:fb36c12 protein

Protein level used designations for MSH6

rCG61559-like , DNA mismatch repair protein Msh6 , mutS homolog 6 (E. coli) , DNA mismatch repair protein Msh6-like , G/T mismatch-binding protein , mutS-alpha 160 kDa subunit , sperm-associated protein , g/T mismatch-binding protein , p160

100360342 Rattus norvegicus
260437 Danio rerio
366547 Rattus norvegicus
421291 Gallus gallus
459218 Pan troglodytes
100033356 Monodelphis domestica
100227810 Taeniopygia guttata
100351645 Oryctolagus cuniculus
100458732 Pongo abelii
100471984 Ailuropoda melanoleuca
100541959 Meleagris gallopavo
100562407 Anolis carolinensis
100593553 Nomascus leucogenys
2956 Homo sapiens
474585 Canis lupus familiaris
17688 Mus musculus
540526 Bos taurus
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