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Browse our MSH6 Proteins (MSH6)

Full name:
MutS Homolog 6 (E. Coli) Proteins (MSH6)
On www.antibodies-online.com are 7 MutS Homolog 6 (E. Coli) (MSH6) Proteins from 3 different suppliers available. Additionally we are shipping MSH6 Antibodies (143) and many more products for this protein. A total of 155 MSH6 products are currently listed.
Synonyms:
AU044881, AW550279, cb326, GTBP, Gtmbp, HNPCC5, HSAP, LOC100227810, p160, wu:fb36c12
list all proteins Gene Name GeneID UniProt
Rat MSH6 MSH6 100360342  
MSH6 2956 P52701
MSH6 17688 P54276

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MSH6 Proteins (MSH6) by Origin

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More Proteins for MSH6 Interaction Partners

Zebrafish MutS Homolog 6 (E. Coli) (MSH6) interaction partners

  1. Studied MSH6 gene expression in developing zebrafish and the influence of MSH6 expression on the production of mismatch binding factors.

  2. Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Proteins) genes, mlh1 (show MLH1 Proteins), msh2 (show MSH2 Proteins), and msh6, in zebrafish that develop tumors at low frequencies.

Human MutS Homolog 6 (E. Coli) (MSH6) interaction partners

  1. human Pol alpha interacts with MSH2 (show MSH2 Proteins)-MSH6 complex

  2. In colorectal neoplasms, negative expression of the MMR (show MRC1 Proteins) proteins MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins) or MSH6 was seen in 15% (47 of 313) of the patients. Defect MLH1 (show MLH1 Proteins) was most common and detected in 12% of the cases. Defect MLH1 (show MLH1 Proteins) and MSH2 (show MSH2 Proteins) were identified in each patient's normal adjacent mucosa.

  3. unlike MutSbeta, MutSalpha may also act to protect against repeat contractions in the Fmr1 (show FMR1 Proteins) gene

  4. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (show MLH1 Proteins) in 40%, MSH2 (show MSH2 Proteins) in 36%, MSH6 in 18% and PMS2 (show PMS2 Proteins) in 6% of the families

  5. There is a positive correlation between the expressions of hMSH2 (show MSH2 Proteins) and hMSH6 between males (RHO=0.673 and p=0.001) and females with colorectal adenocarcinoma.

  6. Individuals with Lynch syndrome and double-mutants in MSH6 and MSH2 (show MSH2 Proteins) had normal MSH2 (show MSH2 Proteins) expression, whereas MSH6 immunoexpression was lost in all evaluable cases.

  7. we identified gene promoter methylation signatures (WT1 (show WT1 Proteins), MSH6, GATA5 (show GATA5 Proteins) and PAX5 (show PAX5 Proteins)) that are strongly correlated to, and can have a predictive value for the clinical outcome of oral squamous cell carcinoma patients

  8. In Lynch syndrome families, prostate cancer was associated with mutations in MSH6 with loss of the mismatch repair protein (show MSH2 Proteins).

  9. Loss of MSH-2 (show MSH2 Proteins)/MSH-6 expression was correlated with the right-colon location, poor and mucinous differentiation in colorectal adenocarcinoma.

  10. Heterozygous germline mutations in any of the mismatch repair (MMR (show MRC1 Proteins)) genes, MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins), MSH6, and PMS2 (show PMS2 Proteins), cause Lynch syndrome (LS), an autosomal dominant cancer predisposition syndrome.

Mouse (Murine) MutS Homolog 6 (E. Coli) (MSH6) interaction partners

  1. we show that AID binds cooperatively with UNG and the mismatch repair proteins Msh2-Msh6 to Ig Smu and Sgamma3 regions

  2. Data suggest that MSH6 protects B cells from neoplastic transformation by preserving genomic stability.

  3. similar defects on switching in Msh2(-/-), Msh2(-/-)Msh6(-/-) and Msh2(-/-)Msh6(-/-)Msh3(-/-) mice confirm that MutSalpha but not MutSbeta plays an important role in class switch recombination

  4. Msh6 deficiency resulted in somatic instability of a (GTG (show GGT1 Proteins))84 repeat.

  5. role for Msh6 in protective cellular responses of primary cells to ultraviolet-B-induced mutagenesis and, hence, the prevention of skin cancer.

  6. Data suggest that MutS homologues Msh2 (show MSH2 Proteins), Msh3, and Msh6 play overlapping and distinct roles during antibody diversification processes.

  7. Data suggest that activation-induced cytidine deaminase (show AICDA Proteins) has limited entry points into V and S regions in vivo, and subsequent mutation requires Msh2 (show MSH2 Proteins)-Msh6, but not Msh3, and DNA polymerase (show POLB Proteins).

  8. Mice nullizygous for both Msh2 (show MSH2 Proteins) and Msh3 and those nullizygous for both Msh3 and Msh6 displayed the greatest overall increases in mutation frequencies compared with wild-type mice.

  9. in Msh6(-/-)Ung (show UNG Proteins)(-/-) mice, mutations were mostly C,G transitions and class switch recombination was greatly reduced.

  10. p53 (show TP53 Proteins) and Msh6 are functionally interrelated and these tumor suppressors act together to accelerate tumorigenesis.

MSH6 Protein Profile

Protein Summary

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Alternative names and synonyms associated with MSH6

  • mutS homolog 6 (E. coli) (LOC100360342)
  • mutS homolog 6 (E. coli) (msh6)
  • mutS homolog 6 (E. coli) (Msh6)
  • mutS homolog 6 (E. coli) (MSH6)
  • mutS homolog 6 (E. coli) (LOC100227810)
  • AU044881 protein
  • AW550279 protein
  • cb326 protein
  • GTBP protein
  • Gtmbp protein
  • HNPCC5 protein
  • HSAP protein
  • LOC100227810 protein
  • p160 protein
  • wu:fb36c12 protein

Protein level used designations for MSH6

rCG61559-like , DNA mismatch repair protein Msh6 , mutS homolog 6 (E. coli) , DNA mismatch repair protein Msh6-like , G/T mismatch-binding protein , mutS-alpha 160 kDa subunit , sperm-associated protein , g/T mismatch-binding protein , p160

GENE ID SPECIES
100360342 Rattus norvegicus
260437 Danio rerio
366547 Rattus norvegicus
421291 Gallus gallus
459218 Pan troglodytes
100033356 Monodelphis domestica
100227810 Taeniopygia guttata
100351645 Oryctolagus cuniculus
100458732 Pongo abelii
100471984 Ailuropoda melanoleuca
100541959 Meleagris gallopavo
100562407 Anolis carolinensis
100593553 Nomascus leucogenys
2956 Homo sapiens
474585 Canis lupus familiaris
17688 Mus musculus
540526 Bos taurus
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