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anti-Human Nibrin Antibodies:
anti-Mouse (Murine) Nibrin Antibodies:
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Human Polyclonal Nibrin Primary Antibody for WB - ABIN361984
Hsu, Shi, Gartenhaus: The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. in Oncogene 2005
Show all 6 Pubmed References
Human Polyclonal Nibrin Primary Antibody for IHC - ABIN966789
Falck, Coates, Jackson: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. in Nature 2005
Show all 4 Pubmed References
Human Monoclonal Nibrin Primary Antibody for ICC, FACS - ABIN1724942
Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. in Molecular carcinogenesis 2011
Show all 2 Pubmed References
Human Monoclonal Nibrin Primary Antibody for ICC, FACS - ABIN1724946
Zuhlke, Johnson, Okoth, Stoffel, Robbins, Tembe, Salinas, Zheng, Xu, Carpten, Lange, Isaacs, Cooney: Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer. in Familial cancer 2012
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Low NBS1 expression is associated with low-grade epithelial ovarian cancer.
although recruitment of the MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1 (MRN) DSB-sensing complex to viral genomes and activation of the ATM (show ATM Antibodies) kinase can promote KSHV replication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplification of viral DNA.
Data suggest HSP90AA1-dependent regulation of ATM-NBN-CHK2 and ATR-CHK1 axes influences cells capability to repair double-stranded DNA damage; mechanisms include phosphorylation, polyubiquitination, and proteasomal degradation/proteolysis. (HSP90AA1 = heat shock protein 90kDa alpha; ATM = ataxia telangiectasia mutated protein; NBN = nibrin; CHK = checkpoint kinase; ATR = ataxia telangiectasia and Rad3 related kinase)
Mre11 (show MRE11A Antibodies)-Rad50 (show RAD50 Antibodies)-Nbs1 complex initiates DNA double strand break repair.
Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired.
The results illuminate the important role of Nbs1 and CtIP (show RBBP8 Antibodies) in determining the substrates and consequences of human Mre11 (show MRE11A Antibodies)/Rad50 (show RAD50 Antibodies) nuclease (show DCLRE1C Antibodies) activities on protein-DNA lesions.
The Nbs1 homologs that promote herpes simplex virus 1 infection also interact with the herpes simplex virus 1 ICP0 protein.
The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer
surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination
although Mre11 (show MRE11A Antibodies) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (show MRE11A Antibodies) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.
the essential role of Nbs1 is via its interaction with Mre11 (show MRE11A Antibodies) and that most of the Nbs1 protein is dispensable for Mre11 (show MRE11A Antibodies) complex functions and suggest that Mre11 (show MRE11A Antibodies) and Rad50 (show RAD50 Antibodies) directly activate ATM (show ATM Antibodies).
Low NBS1 expression is associated with B-cell lymphomas.
findings show that NBS1 is crucial for macrophage function during normal aging
TRIP13 (show TRIP13 Antibodies)-deficient spermatocytes also progress to an H1t (show HIST1H1T Antibodies)-positive stage if ATM (show ATM Antibodies) activity is attenuated by hypomorphic mutations in Mre11 (show MRE11A Antibodies) or Nbs1 or by elimination of the ATM (show ATM Antibodies)-effector kinase CHK2 (show CHEK2 Antibodies)
In the absence of wild type nibrin, the repair of spontaneous errors, presumably arising during DNA replication, makes a major contribution to the basal mutation rate.
Nbs1 mutants initially accumulate replication intermediate, not DSBs.
This report showed that ATM (show ATM Antibodies)-Chk2 (show CHEK2 Antibodies)-P53 (show TP53 Antibodies) signaling pathway and the AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway are responsible for the enhanced apoptosis of the Nbn-deficient mature oligodendrocytes.
JNK (show MAPK8 Antibodies) signaling and ATR (show ATR Antibodies) signaling are likely to converge to regulate the cerebellar apoptosis of newborn Nbn-deficient mice.
Nbn and Atm (show ATM Antibodies) collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner.
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
, Nijmegen breakage syndrome 1 (nibrin)
, cell cycle regulatory protein p95
, p95 protein of the MRE11/RAD50 complex
, nijmegen breakage syndrome protein 1 homolog