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Browse our anti-Nibrin (NBN) Antibodies

Full name:
anti-Nibrin Antibodies (NBN)
On www.antibodies-online.com are 261 Nibrin (NBN) Antibodies from 26 different suppliers available. Additionally we are shipping Nibrin Kits (11) and Nibrin Proteins (7) and many more products for this protein. A total of 290 Nibrin products are currently listed.
Synonyms:
AT-V1, AT-V2, ATV, im:6911679, NBN, NBS, Nbs1, P95, zgc:194152

Most Popular Reactivities for anti-Nibrin (NBN) Antibodies

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anti-Human Nibrin Antibodies:

anti-Mouse (Murine) Nibrin Antibodies:

anti-Rat (Rattus) Nibrin Antibodies:

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Top referenced anti-Nibrin Antibodies

  1. Human Monoclonal Nibrin Primary Antibody for WB - ABIN394539 : Jelonek, Gdowicz-Klosok, Pietrowska, Borkowska, Korfanty, Rzeszowska-Wolny, Widlak: Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. in Journal of applied genetics 2010 (PubMed)
    Show all 5 references for ABIN394539

  2. Human Polyclonal Nibrin Primary Antibody for WB - ABIN197200 : Hsu, Shi, Gartenhaus: The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. in Oncogene 2005 (PubMed)
    Show all 4 references for ABIN197200

  3. Human Polyclonal Nibrin Primary Antibody for WB - ABIN196714 : Falck, Coates, Jackson: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. in Nature 2005 (PubMed)
    Show all 4 references for ABIN196714

  4. Human Polyclonal Nibrin Primary Antibody for FACS, IF - ABIN655721 : Liu, Shete, Wang, El-Zein, Etzel, Liang, Armstrong, Tsavachidis, Gilbert, Aldape, Xing, Wu, Wei, Bondy: Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. in Carcinogenesis 2010 (PubMed)
    Show all 3 references for ABIN655721

  5. Human Monoclonal Nibrin Primary Antibody for ICC, FACS - ABIN1724946 : Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. in Molecular carcinogenesis 2011 (PubMed)
    Show all 2 references for ABIN1724946

  6. Human Monoclonal Nibrin Primary Antibody for ICC, FACS - ABIN1724942 : Zuhlke, Johnson, Okoth, Stoffel, Robbins, Tembe, Salinas, Zheng, Xu, Carpten, Lange, Isaacs, Cooney: Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer. in Familial cancer 2012 (PubMed)
    Show all 2 references for ABIN1724942

  7. Human Polyclonal Nibrin Primary Antibody for ELISA, WB - ABIN1534475 : Varon, Vissinga, Platzer, Cerosaletti, Chrzanowska, Saar, Beckmann, Seemanová, Cooper, Nowak, Stumm, Weemaes, Gatti, Wilson, Digweed, Rosenthal, Sperling, Concannon, Reis: Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. in Cell 1998 (PubMed)
    Show all 2 references for ABIN1534475

  8. Human Polyclonal Nibrin Primary Antibody for IF, ELISA - ABIN1531747 : Carney, Maser, Olivares, Davis, Le Beau, Yates, Hays, Morgan, Petrini: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. in Cell 1998 (PubMed)
    Show all 2 references for ABIN1531747

  9. Human Polyclonal Nibrin Primary Antibody for EIA, FACS - ABIN953701 : Kavitha, Choudhary, Raghavan, Muniyappa: Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 2 references for ABIN953701

More Antibodies against Nibrin Interaction Partners

Human Nibrin (NBN) interaction partners

  1. Study shows that NBS1 may function in histone modification and in the coordination of chromatin remodeling to promote efficient and effective DNA double-strand break repair. [review]

  2. The MRN complex is essential to restrain MYCN (show MYCN Antibodies)-induced replication stress during neural cell proliferation.

  3. kinetics of the accumulation of selected DNA repair-related proteins is protein specific at locally induced DNA lesions, and that the formation of gH2AX- and NBS1-positive foci, but not 53BP1 (show TP53BP1 Antibodies)-positive NBs, is cell cycle dependent in HeLa cells

  4. This study found a significant trend indicating that the risk increases as the number of adverse alleles increase and significant three-locus interaction model involving NBS1 rs1805794, MRE11 (show MRE11A Antibodies) rs10831234, and ATM (show ATM Antibodies) rs227062.

  5. NBS1 expression exhibited an association with epithelial ovarian cancers recurrence.

  6. NBS1 E185Q allele carriers in renal cell carcinoma (show MOK Antibodies) male patients had a lower 5-year survival rate.

  7. The heterozygous variant p.I171V in NBS1 was found at a low frequency and without clinical significance among Korean patients with high-risk breast cancer lacking BRCA1 and BRCA2 (show BRCA2 Antibodies) mutations.

  8. VRK1 (show VRK1 Antibodies) regulation of NBS1 contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.

  9. genetic variants at NBN gene may contribute to gastric cancer susceptibility.

  10. findings reveal a novel model for an intestinal bowel disease phenotype that occurs upon combined loss of the DNA repair cofactors ATMIN (show ATMIN Antibodies) and NBS1

Mouse (Murine) Nibrin (NBN) interaction partners

  1. findings show that NBS1 is crucial for macrophage function during normal aging

  2. TRIP13 (show TRIP13 Antibodies)-deficient spermatocytes also progress to an H1t (show HIST1H1T Antibodies)-positive stage if ATM (show ATM Antibodies) activity is attenuated by hypomorphic mutations in Mre11 (show MRE11A Antibodies) or Nbs1 or by elimination of the ATM (show ATM Antibodies)-effector kinase CHK2 (show CHEK2 Antibodies)

  3. In the absence of wild type nibrin, the repair of spontaneous errors, presumably arising during DNA replication, makes a major contribution to the basal mutation rate.

  4. Nbs1 mutants initially accumulate replication intermediate, not DSBs.

  5. This report showed that ATM (show ATM Antibodies)-Chk2 (show CHEK2 Antibodies)-P53 (show TP53 Antibodies) signaling pathway and the AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway are responsible for the enhanced apoptosis of the Nbn-deficient mature oligodendrocytes.

  6. JNK (show MAPK8 Antibodies) signaling and ATR (show ATR Antibodies) signaling are likely to converge to regulate the cerebellar apoptosis of newborn Nbn-deficient mice.

  7. Nbn and Atm (show ATM Antibodies) collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner.

  8. the antagonism and redundancy of ATMIN (show ATMIN Antibodies) and NBS1 constitute a crucial regulatory mechanism for ATM (show ATM Antibodies) signaling and function.

  9. Nbs1-deficient neocortex shows accumulative endogenous DNA damage and defective activation of Ataxia telangiectasia and Rad3-related (ATR)-Chk1 pathway upon DNA damage.

  10. NBS1 haploinsufficiency results in increased mammary tumor latency and metastasis.

Nibrin (NBN) Antigen Profile

Antigen Summary

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Alternative names and synonyms associated with Nibrin (NBN)

  • nibrin (NBN) antibody
  • nibrin (nbn) antibody
  • nibrin (Nbn) antibody
  • AT-V1 antibody
  • AT-V2 antibody
  • ATV antibody
  • im:6911679 antibody
  • NBN antibody
  • NBS antibody
  • Nbs1 antibody
  • P95 antibody
  • zgc:194152 antibody

Protein level used designations for anti-Nibrin (NBN) Antibodies

nibrin , Nijmegen breakage syndrome 1 (nibrin) , cell cycle regulatory protein p95 , p95 protein of the MRE11/RAD50 complex , nijmegen breakage syndrome protein 1 homolog

GENE ID SPECIES
464278 Pan troglodytes
522943 Bos taurus
100480000 Ailuropoda melanoleuca
100526779 Papio anubis
100557161 Anolis carolinensis
100585384 Nomascus leucogenys
4683 Homo sapiens
27354 Mus musculus
85482 Rattus norvegicus
374246 Gallus gallus
100715565 Cavia porcellus
544655 Danio rerio
100172091 Pongo abelii
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