Browse our anti-Nibrin (NBN) Antibodies

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anti-Nibrin Antibodies (NBN)
On are 269 Nibrin (NBN) Antibodies from 27 different suppliers available. Additionally we are shipping Nibrin Kits (11) and Nibrin Proteins (7) and many more products for this protein. A total of 299 Nibrin products are currently listed.
AT-V1, AT-V2, ATV, im:6911679, NBN, NBS, Nbs1, P95, zgc:194152

Most Popular Reactivities for anti-Nibrin (NBN) Antibodies

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anti-Human Nibrin Antibodies:

anti-Mouse (Murine) Nibrin Antibodies:

anti-Rat (Rattus) Nibrin Antibodies:

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Top referenced anti-Nibrin Antibodies

  1. Human Monoclonal Nibrin Primary Antibody for WB - ABIN394539 : Jelonek, Gdowicz-Klosok, Pietrowska, Borkowska, Korfanty, Rzeszowska-Wolny, Widlak: Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. in Journal of applied genetics 2010 (PubMed)
    Show all 5 references for 394539

  2. Human Polyclonal Nibrin Primary Antibody for WB - ABIN196714 : Hsu, Shi, Gartenhaus: The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. in Oncogene 2005 (PubMed)
    Show all 4 references for 196714

  3. Human Polyclonal Nibrin Primary Antibody for WB - ABIN197200 : Falck, Coates, Jackson: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. in Nature 2005 (PubMed)
    Show all 4 references for 197200

  4. Human Polyclonal Nibrin Primary Antibody for FACS, IF - ABIN655721 : Liu, Shete, Wang, El-Zein, Etzel, Liang, Armstrong, Tsavachidis, Gilbert, Aldape, Xing, Wu, Wei, Bondy: Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. in Carcinogenesis 2010 (PubMed)
    Show all 3 references for 655721

  5. Human Monoclonal Nibrin Primary Antibody for ICC, FACS - ABIN1724942 : Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. in Molecular carcinogenesis 2011 (PubMed)
    Show all 2 references for 1724942

  6. Human Polyclonal Nibrin Primary Antibody for ELISA, WB - ABIN1534475 : Varon, Vissinga, Platzer, Cerosaletti, Chrzanowska, Saar, Beckmann, Seemanová, Cooper, Nowak, Stumm, Weemaes, Gatti, Wilson, Digweed, Rosenthal, Sperling, Concannon, Reis: Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. in Cell 1998 (PubMed)
    Show all 2 references for 1534475

  7. Human Polyclonal Nibrin Primary Antibody for IF, ELISA - ABIN1531747 : Carney, Maser, Olivares, Davis, Le Beau, Yates, Hays, Morgan, Petrini: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. in Cell 1998 (PubMed)
    Show all 2 references for 1531747

  8. Human Polyclonal Nibrin Primary Antibody for EIA, FACS - ABIN953701 : Kavitha, Choudhary, Raghavan, Muniyappa: Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 2 references for 953701

More Antibodies against Nibrin Interaction Partners

Human Nibrin (NBN) interaction partners

  1. Data suggest HSP90AA1-dependent regulation of ATM-NBN-CHK2 and ATR-CHK1 axes influences cells capability to repair double-stranded DNA damage; mechanisms include phosphorylation, polyubiquitination, and proteasomal degradation/proteolysis. (HSP90AA1 = heat shock protein 90kDa alpha; ATM = ataxia telangiectasia mutated protein; NBN = nibrin; CHK = checkpoint kinase; ATR = ataxia telangiectasia and Rad3 related kinase)

  2. Mre11 (show MRE11A Antibodies)-Rad50 (show RAD50 Antibodies)-Nbs1 complex initiates DNA double strand break repair.

  3. Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired.

  4. The results illuminate the important role of Nbs1 and CtIP (show RBBP8 Antibodies) in determining the substrates and consequences of human Mre11 (show MRE11A Antibodies)/Rad50 (show RAD50 Antibodies) nuclease (show DCLRE1C Antibodies) activities on protein-DNA lesions.

  5. The Nbs1 homologs that promote herpes simplex virus 1 infection also interact with the herpes simplex virus 1 ICP0 protein.

  6. The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer

  7. surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination

  8. although Mre11 (show MRE11A Antibodies) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (show MRE11A Antibodies) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.

  9. a somatic missense mutation c.1061C>T (p.P354L) in the NBN gene in a patient with CCS (show CCS Antibodies) lacking an EWSR1 (show EWSR1 Antibodies)-ATF1 (show AFT1 Antibodies) fusion.

  10. The high expression of MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1 complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer

Mouse (Murine) Nibrin (NBN) interaction partners

  1. Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired.

  2. findings show that NBS1 is crucial for macrophage function during normal aging

  3. TRIP13 (show TRIP13 Antibodies)-deficient spermatocytes also progress to an H1t (show HIST1H1T Antibodies)-positive stage if ATM (show ATM Antibodies) activity is attenuated by hypomorphic mutations in Mre11 (show MRE11A Antibodies) or Nbs1 or by elimination of the ATM (show ATM Antibodies)-effector kinase CHK2 (show CHEK2 Antibodies)

  4. In the absence of wild type nibrin, the repair of spontaneous errors, presumably arising during DNA replication, makes a major contribution to the basal mutation rate.

  5. Nbs1 mutants initially accumulate replication intermediate, not DSBs.

  6. This report showed that ATM (show ATM Antibodies)-Chk2 (show CHEK2 Antibodies)-P53 (show TP53 Antibodies) signaling pathway and the AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway are responsible for the enhanced apoptosis of the Nbn-deficient mature oligodendrocytes.

  7. JNK (show MAPK8 Antibodies) signaling and ATR (show ATR Antibodies) signaling are likely to converge to regulate the cerebellar apoptosis of newborn Nbn-deficient mice.

  8. Nbn and Atm (show ATM Antibodies) collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner.

  9. the antagonism and redundancy of ATMIN (show ATMIN Antibodies) and NBS1 constitute a crucial regulatory mechanism for ATM (show ATM Antibodies) signaling and function.

  10. Nbs1-deficient neocortex shows accumulative endogenous DNA damage and defective activation of Ataxia telangiectasia and Rad3-related (ATR)-Chk1 pathway upon DNA damage.

Nibrin (NBN) Antigen Profile

Antigen Summary

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Alternative names and synonyms associated with Nibrin (NBN)

  • nibrin (NBN) antibody
  • nibrin (nbn) antibody
  • nibrin (Nbn) antibody
  • AT-V1 antibody
  • AT-V2 antibody
  • ATV antibody
  • im:6911679 antibody
  • NBN antibody
  • NBS antibody
  • Nbs1 antibody
  • P95 antibody
  • zgc:194152 antibody

Protein level used designations for anti-Nibrin (NBN) Antibodies

nibrin , Nijmegen breakage syndrome 1 (nibrin) , cell cycle regulatory protein p95 , p95 protein of the MRE11/RAD50 complex , nijmegen breakage syndrome protein 1 homolog

464278 Pan troglodytes
522943 Bos taurus
100480000 Ailuropoda melanoleuca
100526779 Papio anubis
100557161 Anolis carolinensis
100585384 Nomascus leucogenys
4683 Homo sapiens
27354 Mus musculus
85482 Rattus norvegicus
374246 Gallus gallus
100715565 Cavia porcellus
544655 Danio rerio
100172091 Pongo abelii
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