Browse our X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Proteins (XRCC6)

Full name:
X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Proteins (XRCC6)
On www.antibodies-online.com are 10 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) Proteins from 5 different suppliers available. Additionally we are shipping X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Antibodies (337) and X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Kits (16) and many more products for this protein. A total of 384 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 products are currently listed.
Synonyms:
70kDa, CTC75, CTCBF, G22p1, Ku70, Kup70, ML8, TLAA
list all proteins Gene Name GeneID UniProt
XRCC6 2547 P12956
XRCC6 14375 P23475
XRCC6 25019  

Show all synonyms

X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Proteins (XRCC6) by Origin

Select your origin of interest

More Proteins for X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Interaction Partners

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) interaction partners

  1. VCP removes sterically trapped Ku70/80 rings from DNA in double-strand break repair.

  2. found that the rs228593, rs2267437 and rs1805388 functional polymorphisms probably alter the level of expression of the ATM (show ATM Proteins), XRCC6 and LIG4 (show LIG4 Proteins) genes, respectively, being important in the maintenance of genomic instability in MDS (show PAFAH1B1 Proteins)

  3. Data show that the increased acetylation of Ku autoantigen 70kDa (Ku70) in sirtuin 6 (show SIRT6 Proteins) protein (SIRT6 (show SIRT6 Proteins))-depleted cells disrupt its interaction with Bax (show BAX Proteins) apoptosis regulator protein (Bax (show BAX Proteins)), which finally resulted in Bax (show BAX Proteins) mitochondrial translocalization.

  4. Ku70 (XRCC6) was found to bind directly within the CR4 of E1A (show BCKDHA Proteins) from human adenovirus type 5.

  5. periodic phosphorylation of Ku70 by cyclin-cyclin (show PCNA Proteins) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.

  6. The results of this preclinical study imply that Ku70 might be a primary resistance factor of gemcitabine, and Ku70 silence could significantly chemo-sensitize gemcitabine in pancreatic cancer cells.

  7. results reveal that Src (show SRC Proteins) plays a protective role against hyperactive apoptotic cell death by reducing apoptotic susceptibility through phosphorylation of Ku70 at Tyr (show TYR Proteins)-530.

  8. High Expression of XRCC6 Promotes Human Osteosarcoma Cell Proliferation through the beta-Catenin (show CTNNB1 Proteins)/Wnt (show WNT2 Proteins) Signaling Pathway.

  9. Data show that X-ray repair cross-complementing protein 6 ( Ku70) is found to interact with closed circular DNA.

  10. The rs2267437 in XRCC6 was associated with increased initial DSB damage.

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) interaction partners

  1. Study found that emphysema occurred in ku70(-/-) mice at the age of three-months old, and that Bax deficiency was able to suppress it. These results suggest that Bax-mediated apoptosis induces emphysema in ku70(-/-) mice.

  2. Bax deficiency appeared to delay the development of emphysema. This study suggests that enhanced Bax activity exacerbates the negative impact of Ku70 deletion

  3. Ku (ku70/ku80 (show XRCC5 Proteins) heterodimer)roles in nonhomologous end joining and base excision repair pathways of DNA repair are overviewed.

  4. A novel role for free Ku70 and free Ku80 (show XRCC5 Proteins) in altering base excision repair.

  5. A novel function of Ku70 essential for colon homeostasis.

  6. Overexpression of Bcl2 rescues the hematopoietic stem cell defect in Ku70-deficient mice by restoration of quiescence.

  7. This study highlights Ku70 as an important player not only in maintaining genomic stability through NHEJ-dependent functions, but also in regulating pancreatic beta-cell proliferation, a novel NHEJ-independent function.

  8. Ku70/80 binds to DNA double strand breaks (DSB) in all cell cycle stages and is likely actively displaced from DSB ends to free the DNA ends for DNA end resection and thus homologous recombination to occur.

  9. The findings suggest that Artemis (show DCLRE1C Proteins) can work in not only the Ku-dependent repair process, but also the Ku-independent process at DNA double-strand break in living epithelial cells.

  10. These findings clearly indicate that Ku70 plays a key role in regulation of the Ku80 (show XRCC5 Proteins) expression level in and the radioresistance of lung epithelial cells.

X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) Protein Profile

Protein Summary

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.

Alternative names and synonyms associated with X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6)

  • X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6)
  • ATP-dependent DNA helicase II, 70 kDa subunit (Bm1_41430)
  • ATP-dependent DNA helicase II, 70 kDa subunit (LOC100351956)
  • X-ray repair complementing defective repair in Chinese hamster cells 6 (xrcc6)
  • X-ray repair complementing defective repair in Chinese hamster cells 6 (Xrcc6)
  • 70kDa protein
  • CTC75 protein
  • CTCBF protein
  • G22p1 protein
  • Ku70 protein
  • Kup70 protein
  • ML8 protein
  • TLAA protein

Protein level used designations for XRCC6

ATP-dependent DNA helicase 2 subunit 1 , ATP-dependent DNA helicase II, 70 kDa subunit , X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) , X-ray repair cross-complementing protein 6 , 5'-dRP lyase Ku70 , 5'-deoxyribose-5-phosphate lyase Ku70 , 70 kDa subunit of Ku antigen , ATP-dependent DNA helicase II 70 kDa subunit , CTC box binding factor 75 kDa subunit , CTC box-binding factor 75 kDa subunit , DNA repair protein XRCC6 , Ku autoantigen p70 subunit , Ku autoantigen, 70kDa , lupus Ku autoantigen protein p70 , thyroid autoantigen 70kD (Ku antigen) , thyroid autoantigen 70kDa (Ku antigen) , thyroid-lupus autoantigen p70 , 5'-dRP/AP lyase Ku70 , CTC75 , CTCBF , Ku p70 , ku autoantigen protein p70 homolog , thyroid autoantigen 70 kDa , Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa) , thyroid autoantigen , X-ray repair cross-complementing protein 5

GENE ID SPECIES
465902 Pan troglodytes
6103167 Brugia malayi
100351956 Oryctolagus cuniculus
398357 Xenopus laevis
474485 Canis lupus familiaris
510132 Bos taurus
707975 Macaca mulatta
100173902 Pongo abelii
2547 Homo sapiens
14375 Mus musculus
25019 Rattus norvegicus
395767 Gallus gallus
Selected quality suppliers for X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Proteins (XRCC6)
Did you look for something else?