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Browse our X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Proteins (XRCC6)

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X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Proteins (XRCC6)
On www.antibodies-online.com are 8 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) Proteins from 6 different suppliers available. Additionally we are shipping X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Antibodies (259) and X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Kits (14) and many more products for this protein. A total of 303 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 products are currently listed.
Synonyms:
70kDa, CTC75, CTCBF, G22p1, Ku70, Kup70, ML8, TLAA
list all proteins Gene Name GeneID UniProt
XRCC6 2547 P12956
XRCC6 14375 P23475
XRCC6 25019  

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X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Proteins (XRCC6) by Origin

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More Proteins for X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 Interaction Partners

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) interaction partners

  1. We believe that for the first time, genetic variants at XRCC6 and MVP (show MVP Proteins) genes are associated with risk of more aggressive disease, and would be taken into account when assessing the malignancy of prostate cancer

  2. XRCC6 may play an important role in the carcinogenesis of NPC (show NPC1 Proteins) and could serve as a chemotherapeutic target for personalized medicine and therapy.

  3. these data unveil an involvement of phospho-Ku70 in fast but inaccurate DNA repair; a new paradigm linked to both the deregulation of canonical nonhomologous end-joining and the resistance of malignant cells

  4. Data suggest that heat shock factor 1 (HSF1) interacts with both Ku autoantigens Ku70 and Ku86 to induce defective non-homologous end joining (NHEJ) repair activity and genomic instability.

  5. Our results demonstrate that the phosphorylation-mediated dissociation of Ku70/80 from DSBs frees DNA ends, allowing the initiation of HR in S phase and providing a mechanism of DSB repair pathway choice in mammalian cells.

  6. retinoblastoma tumor suppressor protein (show TP53 Proteins) variants disabled for the interaction with XRCC5 (show XRCC5 Proteins) and XRCC6, including a cancer-associated variant, are unable to support canonical non-homologous end-joining despite being able to confer cell-cycle control

  7. the results of the present study suggested that Ku70 acetylation mediated TSA (show PRDX2 Proteins)-induced apoptosis in CRC (show CALR Proteins) cells. In addition, Ku70 was found to be indispensable in TSA (show PRDX2 Proteins)-induced apoptosis due to its role in protecting Bax (show BAX Proteins) from proteosomal degradation.

  8. A direct interaction between Ku70/86 and BRG1 (show SMARCA4 Proteins) brings together SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) remodeling capabilities and TOP2beta (show TOP2B Proteins) activity to enhance the transcriptional response to hormone stimulation.

  9. Ku70 is a novel Mcl-1 (show MCL1 Proteins) deubiquitinase that could be a potential target for cancer therapy by manipulating Mcl-1 (show MCL1 Proteins) deubiquitination.

  10. SMAR1 (show BANP Proteins)-mediated regulation of repair and apoptosis via a complex crosstalk involving Ku70, HDAC6 (show HDAC6 Proteins) and Bax (show BAX Proteins).

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) interaction partners

  1. Bax deficiency appeared to delay the development of emphysema. This study suggests that enhanced Bax activity exacerbates the negative impact of Ku70 deletion

  2. Ku (ku70/ku80 (show XRCC5 Proteins) heterodimer)roles in nonhomologous end joining and base excision repair pathways of DNA repair are overviewed.

  3. A novel role for free Ku70 and free Ku80 (show XRCC5 Proteins) in altering base excision repair.

  4. A novel function of Ku70 essential for colon homeostasis.

  5. Overexpression of Bcl2 rescues the hematopoietic stem cell defect in Ku70-deficient mice by restoration of quiescence.

  6. This study highlights Ku70 as an important player not only in maintaining genomic stability through NHEJ-dependent functions, but also in regulating pancreatic beta-cell proliferation, a novel NHEJ-independent function.

  7. Ku70/80 binds to DNA double strand breaks (DSB) in all cell cycle stages and is likely actively displaced from DSB ends to free the DNA ends for DNA end resection and thus homologous recombination to occur.

  8. The findings suggest that Artemis (show DCLRE1C Proteins) can work in not only the Ku-dependent repair process, but also the Ku-independent process at DNA double-strand break in living epithelial cells.

  9. These findings clearly indicate that Ku70 plays a key role in regulation of the Ku80 (show XRCC5 Proteins) expression level in and the radioresistance of lung epithelial cells.

  10. Ku70/86 binds to the Apaf1 (show APAF1 Proteins) promoter and represses its activity.

X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6) Protein Profile

Protein Summary

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.

Alternative names and synonyms associated with X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6)

  • X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6)
  • ATP-dependent DNA helicase II, 70 kDa subunit (Bm1_41430)
  • ATP-dependent DNA helicase II, 70 kDa subunit (LOC100351956)
  • X-ray repair complementing defective repair in Chinese hamster cells 6 (xrcc6)
  • X-ray repair complementing defective repair in Chinese hamster cells 6 (Xrcc6)
  • 70kDa protein
  • CTC75 protein
  • CTCBF protein
  • G22p1 protein
  • Ku70 protein
  • Kup70 protein
  • ML8 protein
  • TLAA protein

Protein level used designations for XRCC6

ATP-dependent DNA helicase 2 subunit 1 , ATP-dependent DNA helicase II, 70 kDa subunit , X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) , X-ray repair cross-complementing protein 6 , 5'-dRP lyase Ku70 , 5'-deoxyribose-5-phosphate lyase Ku70 , 70 kDa subunit of Ku antigen , ATP-dependent DNA helicase II 70 kDa subunit , CTC box binding factor 75 kDa subunit , CTC box-binding factor 75 kDa subunit , DNA repair protein XRCC6 , Ku autoantigen p70 subunit , Ku autoantigen, 70kDa , lupus Ku autoantigen protein p70 , thyroid autoantigen 70kD (Ku antigen) , thyroid autoantigen 70kDa (Ku antigen) , thyroid-lupus autoantigen p70 , 5'-dRP/AP lyase Ku70 , CTC75 , CTCBF , Ku p70 , ku autoantigen protein p70 homolog , thyroid autoantigen 70 kDa , Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa) , thyroid autoantigen , X-ray repair cross-complementing protein 5

GENE ID SPECIES
465902 Pan troglodytes
6103167 Brugia malayi
100351956 Oryctolagus cuniculus
398357 Xenopus laevis
474485 Canis lupus familiaris
510132 Bos taurus
707975 Macaca mulatta
100173902 Pongo abelii
2547 Homo sapiens
14375 Mus musculus
25019 Rattus norvegicus
395767 Gallus gallus
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