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Browse our Adrenergic, Beta, Receptor Kinase 1 Proteins (ADRBK1)

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Adrenergic, Beta, Receptor Kinase 1 Proteins (ADRBK1)
On are 6 Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Proteins from 6 different suppliers available. Additionally we are shipping Adrenergic, Beta, Receptor Kinase 1 Antibodies (111) and Adrenergic, Beta, Receptor Kinase 1 Kits (16) and many more products for this protein. A total of 149 Adrenergic, Beta, Receptor Kinase 1 products are currently listed.
Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, Grk2
list all proteins Gene Name GeneID UniProt
Mouse ADRBK1 ADRBK1 110355  
ADRBK1 156 P25098
ADRBK1 25238 P26817

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Adrenergic, Beta, Receptor Kinase 1 Proteins (ADRBK1) by Origin

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Top referenced Adrenergic, Beta, Receptor Kinase 1 Proteins

  1. Human ADRBK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004759 : Aragay, Mellado, Frade, Martin, Jimenez-Sainz, Martinez-A, Mayor: Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
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More Proteins for Adrenergic, Beta, Receptor Kinase 1 Interaction Partners

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. In vitro, GRK2 inhibits Epac1-to-Rap1 signaling by phosphorylation of Epac1 at Ser-108 in the Disheveled/Egl-10/pleckstrin domain. GRK2 inhibits Epac1-mediated sensitization of Piezo2 which contributes to inflammatory mechanical hyperalgesia.

  2. GRK2 ablation increases circadian amplitude and decreases circadian period. GRK2 suppresses mPeriod1 transcription,PERIOD1/2 nuclear trafficking and promotes PERIOD2 phosphorylation.

  3. These results suggest GRK2 contributes to melanopsin (show OPN4 Proteins) deactivation, but that other mechanisms account for most of modulation of melanopsin (show OPN4 Proteins) activity in ipRGCs.

  4. data suggest that inhibiting GRK2 could reverse an established insulin (show INS Proteins)-resistant and obese phenotype

  5. Post-MI AdipoR1 (show ADIPOR1 Proteins) phosphorylation positively correlated with the expression level of GRK2. AdipoR1 (show ADIPOR1 Proteins) is phosphorylatively modified and desensitized by GRK2 in failing cardiomyocytes, contributing to post-MI remodeling and HF progression.

  6. findings indicate that the balance between mechanisms regulating vascular tone are shifted to favor vasoconstriction in the absence of GRK2 expression and that this leads to the age-dependent development of hypertension

  7. Data indicate that G protein-coupled receptor kinase 2 (GRK2) downregulation enhances insulin (show INS Proteins) signaling in adult mouse hearts.

  8. Findings reveal a cell-type-specific role for GRK2 in the regulation of normal motor behavior, sensitivity to psychostimulants, dopamine neurotransmission, and D2 autoreceptor function

  9. Attenuation of GRK2 is associated with defective differentiation of somatic muscles.

  10. These data demonstrate that GRK2 modulates FcinRI signaling in mast cells via at least two mechanisms.One involves GRK2-RH and modulates tyrosine phosphorylation of Syk (show SYK Proteins), and the other is mediated via the phosphorylation of p38 (show CRK Proteins) and Akt (show AKT1 Proteins).

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK (show GRK4 Proteins).

  2. Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.

  3. G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}

  4. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.

  5. intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).

  6. epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit (show POLG Proteins) and renders the channels insensitive to inhibition by Nedd4-2 (show NEDD4L Proteins).

  7. Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.

  8. Resultrs suggest that activated platelet-derived growth factor receptor-beta (show PDGFRB Proteins) (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.

  9. GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor (show OPRM1 Proteins)

  10. atomic structure of GRK2 in complex with Galphaq (show GNAQ Proteins) and Gbetagamma, in which activated Galpha (show SUCLG1 Proteins) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [Galphaq (show GNAQ Proteins), Gbetagamma

Human Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. It is a critical factor in diabetic endothelial dysfunction and plays a role in many physiological functions including regulation of G-protein-coupled receptors (GPCRs). (review)

  2. Suggest a common regulatory pattern for the beta(2)-AR/GRK2 which is independent of cellular type or pathology.

  3. Suggest role for GRK2 in the regulating cardiac hypertrophy.

  4. the dual-specific GRK2 and ERK (show EPHB2 Proteins) cascade inhibitor, RKIP (Raf kinase inhibitor protein (show PEBP1 Proteins)), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg (show PPARG Proteins)-regulated genes.

  5. Acute mental stress significantly increased GRK2 density in in peripheral blood mononuclear cells of young adult males.

  6. It plays a role in progression of Vasculature which is affected by insulin (show INS Proteins) resistance and type 2 diabetes expresses high levels of GRK2

  7. Data suggest that, by targeting/repressing GRK2, microRNA-K3 of Kaposi sarcoma-associated herpesvirus (KSHV) facilitates migration and invasion of vascular endothelial cells via activation of CXCR2 (show CXCR2 Proteins)/AKT (show AKT1 Proteins) signaling.

  8. Acute aerobic exercise induces a greater GRK2 expression in women than men, while increased cardiorespiratory fitness is associated with exercise-induced GRK2 expression in PBMCs

  9. Data indicate that protein kinase (show CDK7 Proteins) GRK2 silencing abolished isoproterenol-induced phosphorylation of beta2-adrenergic receptor (show ADRB2 Proteins) (beta2ARs).

  10. G protein beta subunits (Gb) bind to DDB1 and Gb2 targets GRK2 for ubiquitylation by the DDB1-CUL4A-ROC1 ubiquitin ligase.

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Protein Profile

Protein Summary

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Alternative names and synonyms associated with Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

  • beta-adrenergic receptor kinase 1 (Tsp_00497)
  • adrenergic, beta, receptor kinase 1 (adrbk1)
  • adrenergic receptor kinase, beta 1 (Adrbk1)
  • adrenergic, beta, receptor kinase 1 (ADRBK1)
  • adrenergic, beta, receptor kinase 1 (Adrbk1)
  • Adrbk-1 protein
  • Bark-1 protein
  • BARK1 protein
  • BETA-ARK1 protein
  • betaARK1 protein
  • GRK-2 protein
  • Grk2 protein

Protein level used designations for ADRBK1

beta-adrenergic receptor kinase 1 , adrenergic, beta, receptor kinase 1 , G-protein-coupled receptor kinase 2 , beta ARK , beta ARK1 , beta-AR kinase-1 , beta-ARK-1 , beta-adrenergic receptor kinase-1 , G-protein coupled receptor kinase 2 , adrenergic receptor kinase, beta 1 , beta-adrenergic receptor kinase 1 beta ARK1

10901826 Trichinella spiralis
100555775 Anolis carolinensis
110355 Mus musculus
282682 Bos taurus
156 Homo sapiens
25238 Rattus norvegicus
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