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Browse our Adrenergic, Beta, Receptor Kinase 1 Proteins (ADRBK1)

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Adrenergic, Beta, Receptor Kinase 1 Proteins (ADRBK1)
On www.antibodies-online.com are 9 Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Proteins from 8 different suppliers available. Additionally we are shipping Adrenergic, Beta, Receptor Kinase 1 Antibodies (126) and Adrenergic, Beta, Receptor Kinase 1 Kits (18) and many more products for this protein. A total of 168 Adrenergic, Beta, Receptor Kinase 1 products are currently listed.
Synonyms:
Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, Grk2
list all proteins Gene Name GeneID UniProt
ADRBK1 110355  
ADRBK1 156 P25098
ADRBK1 25238 P26817

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Adrenergic, Beta, Receptor Kinase 1 Proteins (ADRBK1) by Origin

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Top referenced Adrenergic, Beta, Receptor Kinase 1 Proteins

  1. Human ADRBK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004759 : Aragay, Mellado, Frade, Martin, Jimenez-Sainz, Martinez-A, Mayor: Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
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More Proteins for Adrenergic, Beta, Receptor Kinase 1 Interaction Partners

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. study provides the first insights into the role of GRK2 in skeletal muscle physiology and points to a role for GRK2 as a modulator of contractile properties in skeletal muscle as well as beta2AR (show ADRB2 Proteins)-induced hypertrophy.

  2. GRK2 loss confers a protective advantage over control mice after myocardial ischemia/reperfusion injury. Fibroblast GRK2 knockout mice presented with decreased infarct size and preserved cardiac function 24 hours post ischemia/reperfusion. They had decreased fibrosis and fibrotic gene expression. These protective effects correlated with decreased infiltration of neutrophils to the ischemia site and decreased TNF-alpha (show TNF Proteins).

  3. this study shows that astragaloside IV alleviates E. coli-caused peritonitis through modulating GRK2-CXCR2 (show CXCR2 Proteins) signal in neutrophils

  4. GRK2 down-regulation is cardioprotective during diet-induced obesity, reinforcing the protective effect of maintaining low levels of GRK2 under nutritional stress, and showing a role for this kinase in obesity-induced cardiac remodeling and steatosis.

  5. The betaARKrgs peptide, but not endogenous GRK2, interacted with Galpha(q (show GNAQ Proteins)) and interfered with signaling through this G protein. These data support the development of GRK2-based therapeutic approaches to prevent hypertrophy and heart failure.

  6. GRK2 is localized in the mitochondria and its kinase activity negatively impacts the function of this organelle by increasing superoxide levels and altering substrate utilization for energy production.

  7. Erythropoietin (show EPO Proteins) seems to reverse sepsis-induced vasoplegia to NE through the preservation of alpha1D adrenoceptor mRNA/protein expression, inhibition of GRK2-mediated desensitization, and attenuation of NO overproduction in the mouse aorta.

  8. In vitro, GRK2 inhibits Epac1-to-Rap1 signaling by phosphorylation of Epac1 at Ser-108 in the Disheveled/Egl-10/pleckstrin domain. GRK2 inhibits Epac1-mediated sensitization of Piezo2 which contributes to inflammatory mechanical hyperalgesia.

  9. GRK2 ablation increases circadian amplitude and decreases circadian period. GRK2 suppresses mPeriod1 transcription,PERIOD1/2 nuclear trafficking and promotes PERIOD2 phosphorylation.

  10. These results suggest GRK2 contributes to melanopsin (show OPN4 Proteins) deactivation, but that other mechanisms account for most of modulation of melanopsin (show OPN4 Proteins) activity in ipRGCs.

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain.

  2. Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK (show GRK4 Proteins).

  3. Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.

  4. G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}

  5. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.

  6. intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).

  7. epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit (show POLG Proteins) and renders the channels insensitive to inhibition by Nedd4-2 (show NEDD4L Proteins).

  8. Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.

  9. Resultrs suggest that activated platelet-derived growth factor receptor-beta (show PDGFRB Proteins) (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.

  10. GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor (show OPRM1 Proteins)

Human Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. The dominant model (CC vs. CT+TT) of rs1894111 polymorphism in the ADRBK1 gene might be associated with low-renin hypertension in Han Chinese.

  2. Our data suggest that GRK2 acts as an important onco-modulator by strengthening the functionality of key players in breast tumorigenesis such as HDAC6 (show HDAC6 Proteins) and Pin1 (show PIN1 Proteins).

  3. GRK2 may inhibit IGF1 (show IGF1 Proteins)-induced human hepatocellular carcinoma cell growth and migration through downregulation of EGR1 (show EGR1 Proteins).

  4. It is a critical factor in diabetic endothelial dysfunction and plays a role in many physiological functions including regulation of G-protein-coupled receptors (GPCRs). (review)

  5. Suggest a common regulatory pattern for the beta(2)-AR/GRK2 which is independent of cellular type or pathology.

  6. Suggest role for GRK2 in the regulating cardiac hypertrophy.

  7. the dual-specific GRK2 and ERK (show EPHB2 Proteins) cascade inhibitor, RKIP (Raf kinase inhibitor protein (show PEBP1 Proteins)), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg (show PPARG Proteins)-regulated genes.

  8. Acute mental stress significantly increased GRK2 density in in peripheral blood mononuclear cells of young adult males.

  9. It plays a role in progression of Vasculature which is affected by insulin (show INS Proteins) resistance and type 2 diabetes expresses high levels of GRK2

  10. Data suggest that, by targeting/repressing GRK2, microRNA-K3 of Kaposi sarcoma-associated herpesvirus (KSHV) facilitates migration and invasion of vascular endothelial cells via activation of CXCR2 (show CXCR2 Proteins)/AKT (show AKT1 Proteins) signaling.

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Protein Profile

Protein Summary

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Alternative names and synonyms associated with Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

  • beta-adrenergic receptor kinase 1 (Tsp_00497)
  • adrenergic, beta, receptor kinase 1 (adrbk1)
  • adrenergic receptor kinase, beta 1 (Adrbk1)
  • adrenergic, beta, receptor kinase 1 (ADRBK1)
  • adrenergic, beta, receptor kinase 1 (Adrbk1)
  • Adrbk-1 protein
  • Bark-1 protein
  • BARK1 protein
  • BETA-ARK1 protein
  • betaARK1 protein
  • GRK-2 protein
  • Grk2 protein

Protein level used designations for ADRBK1

beta-adrenergic receptor kinase 1 , adrenergic, beta, receptor kinase 1 , G-protein-coupled receptor kinase 2 , beta ARK , beta ARK1 , beta-AR kinase-1 , beta-ARK-1 , beta-adrenergic receptor kinase-1 , G-protein coupled receptor kinase 2 , adrenergic receptor kinase, beta 1 , beta-adrenergic receptor kinase 1 beta ARK1

GENE ID SPECIES
10901826 Trichinella spiralis
100555775 Anolis carolinensis
110355 Mus musculus
282682 Bos taurus
156 Homo sapiens
25238 Rattus norvegicus
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