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Tideglusib significantly reduced cerebral infarct volume at both 24h and 7days after HI injury. Tideglusib also increased phosphorylated GSK-3beta (show GSK3b ELISA Kits)(Ser9) and Akt (show AKT1 ELISA Kits)(Ser473)
Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT (show AKT1 ELISA Kits)/GSK3beta (show GSK3b ELISA Kits) signaling axis at cilia in SHH (show SHH ELISA Kits)-dependent medulloblastoma that is regulated by INPP5E (show INPP5E ELISA Kits) to maintain tumor cell cilia, promote SHH (show SHH ELISA Kits) signaling and thereby medulloblastoma progression.
mTORC2 (show CRTC2 ELISA Kits) complex is responsible for phosphorylating Akt (show AKT1 ELISA Kits) at S(473).
FHL2 (show FHL2 ELISA Kits) facilitates ovarian granulosa cell tumor progression via controlling AKT1 (show AKT1 ELISA Kits) transcription.
Omentin (show ITLN1 ELISA Kits) protects against lipopysaccharides-induced acute respiratory distress syndrome through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt (show AKT1 ELISA Kits)/NOS3 (show NOS3 ELISA Kits)-dependent mechanism.
AIM2 (show AIM2 ELISA Kits) contributes to the maintenance of intestinal integrity via Akt (show AKT1 ELISA Kits) and protects against Salmonella mucosal infection.
Following transepithelial migration, neutrophils adhesion to ICAM-1 (show ICAM1 ELISA Kits) resulted in activation of Akt (show AKT1 ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits) signaling, increased epithelial-cell proliferation, and wound healing.
Besides, both in vivo and in votro studies suggested that K145 stimulated insulin (show INS ELISA Kits) dependent Akt (show AKT1 ELISA Kits) phosphorylation and subsequently activates FoxO1 (show FOXO1 ELISA Kits) phosphorylation therefore inhibited gluconeogenetic genes expression including PEPCK (show PEPCK ELISA Kits) and G6pase (show G6PC ELISA Kits). Our study figures out a potential extent increase the value of developing K145 as therapeutic candidate for diabetes.
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt (show AKT1 ELISA Kits) in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt (show AKT1 ELISA Kits) in heart.
High Akt1 (show AKT1 ELISA Kits) expression is associated with hepatocarcinogenesis.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (show CTNNB1 ELISA Kits) in the crosstalk between Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) and Wnt (show WNT2 ELISA Kits)/Ca(2 (show CA2 ELISA Kits)+) signaling pathways upon Wnt3a (show WNT3A ELISA Kits) stimulation in differentiating hNPCs.
STIM1 (show STIM1 ELISA Kits)-induced Ca(2 (show CA2 ELISA Kits)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (show PTPRB ELISA Kits) and VE-cadherin (show CDH5 ELISA Kits) and hence increase endothelial permeability.
Ascites and CCL18 (show CCL18 ELISA Kits) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin (show 0 ELISA Kits), a process in part mediated through the PI3-kinase (show PIK3CA ELISA Kits)-Akt/PKB (show AKT1 ELISA Kits) cell survival pathway. These results provide further rationale for clinical investigation of relaxin (show 0 ELISA Kits) as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Studies suggest that PYK2 is a common downstream effector of ErbB (show EGFR ELISA Kits) and IL8 (show IL8 ELISA Kits) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.
Pyk2 is a key downstream signaling molecules of CCR7 (show CCR7 ELISA Kits) in SCCHN, which promotes SCCHN tumorigenesis and progression.
Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.
Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN ELISA Kits).
Src (show SRC ELISA Kits) has a role in priming Pyk2 (but not FAK (show PTK2 ELISA Kits)) phosphorylation and subsequent activation downstream of integrins
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
, PKB alpha
, RAC protein kinase alpha RAC-PK alpha
, RAC-alpha serine/threonine-protein kinase
, murine thymoma viral (v-akt) oncogene homolog 1
, protein kinase B alpha
, thymoma viral proto-oncogene 1
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, FADK 2
, PTK2B protein tyrosine kinase 2 beta
, calcium-dependent tyrosine kinase
, calcium-regulated non-receptor proline-rich tyrosine kinase
, cell adhesion kinase beta
, focal adhesion kinase 2
, proline-rich tyrosine kinase 2
, protein kinase B
, protein-tyrosine kinase 2-beta
, related adhesion focal tyrosine kinase
, CAK beta
, PTK2 protein tyrosine kinase 2 beta
, cellular adhesion kinase beta
, protein tyrosine kinase 2 beta