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study reveals the crucial role of miR (show MLXIP Proteins)-155/PTPRJ/AKT (show AKT1 Proteins) axis in proliferation and migration of colorectal cancer cells and suggests a therapeutic potential of PTPRJ.
Authors demonstrate that mtp53 prevents the COP1 (show CARD16 Proteins)/DET1 complex from ubiquitinating ETS2 (show ETS2 Proteins) and thereby marking it for destruction. Authors show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 (show ETS2 Proteins) complex thereby preventing ETS2 (show ETS2 Proteins) degradation.
These data support that PTPN22 (show PTPN22 Proteins) 1858C/T, PTPRJ 2965C/G and 1176 A/C polymorphisms and ACP1 A (show ACP1 Proteins), B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults.
Loss of PTPRJ expression may predict an aggressive clinical course in ESCC patients.
The strongest association with frailty was observed in the Protein Tyrosine Phosphatase (show ACP1 Proteins), Receptor type, J (PTPRJ) (rs1566729, P = 0.001372, beta = 0.09397) gene.
the combination of CD200 (show CD200 Proteins) and CD148 may have a potential differential diagnostic value in leukemic B-CLPDs, especially between CLL and MCL (show FH Proteins).
These results demonstrated Ptprj as a physiological enzyme that attenuates insulin (show INS Proteins) signalling in vivo, and indicate that an inhibitor of Ptprj may be an insulin (show INS Proteins)-sensitizing agent.
CD148 tyrosine phosphatase promotes e-cadherin (show CDH1 Proteins) cell adhesion.
The studies suggest induction of MMP-9 (show MMP9 Proteins) expression promoted by DEP-1 deficiency.
Moderate expression of DEP-1 was associated with the increased relapse.
our results established DEP-1 as an essential driver of VEGF-dependent permeability, angiogenesis, and metastasis
DEP-1 acts as an endogenous antagonist of the insulin receptor (show INSR Proteins), and downregulation of DEP-1 results in an improvement of insulin (show INS Proteins) sensitivity.
Data indicate that CD148 mRNA is upregulated in diseased joints of with collagen-induced arthritis.
The large ectodomains of CD45 and CD148 modulate their inhibitory effect by enabling their passive, size-based segregation from ligated TCR, supporting the kinetic-segregation model of TCR triggering.
phosphatase CD148 promotes airway hyperresponsiveness through SRC (show SRC Proteins) family kinases
These data indicate that PTPRJ may regulate differentiation of normal mammary epithelia and that dysregulation of protein localisation may be associated with tumorigenesis.
CD148 plays a dominant role in activating Src (show SRC Proteins) family kinases in platelets relative to PTP-1B (show PTPN1 Proteins). Both PTPs (show PTS Proteins) are required for optimal platelet activation and aggregate formation under high arterial shear rates.
CD45 and CD148 preferentially target different SFK members (Hck and Fgr versus Lyn, respectively) to positively and negatively regulate GPCR pathways.
differential effects of CD148 in T cells and other leukocyte subsets
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
receptor-type tyrosine-protein phosphatase eta
, density enhanced phosphatase-1
, protein tyrosine phosphatase, receptor type, J
, receptor-type tyrosine-protein phosphatase eta-like
, CD148 antigen
, HPTP eta
, density-enhanced phosphatase 1
, human density enhanced phosphatase-1
, protein tyrosine phosphatase, receptor type, J polypeptide
, protein-tyrosine phosphatase eta
, protein-tyrosine phosphatase receptor type J
, susceptibility to colon cancer 1, mouse, homolog of
, HPTP beta-like tyrosine phosphatase
, colon tumor susceptibility 1
, susceptibility to colon cancer 1
, supporting-cell antigen