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Browse our PTPRJ Proteins (PTPRJ)

Full name:
Protein tyrosine Phosphatase, Receptor Type, J Proteins (PTPRJ)
On www.antibodies-online.com are 12 Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) Proteins from 6 different suppliers available. Additionally we are shipping PTPRJ Antibodies (79) and PTPRJ Kits (7) and many more products for this protein. A total of 99 PTPRJ products are currently listed.
Synonyms:
AI450271, BET, Byp, CD148, DEP-1, DEP1, HPTPeta, Ptpb2, PTPbeta2, PTPRJ, R-PTP-ETA, RPTPJ, Scc-1, Scc1
list all proteins Gene Name GeneID UniProt
Rat PTPRJ PTPRJ 29645  
PTPRJ 5795 Q12913
PTPRJ 19271 Q64455

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PTPRJ Proteins (PTPRJ) by Origin

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Top referenced PTPRJ Proteins

  1. Human PTPRJ Protein expressed in Escherichia coli (E. coli) - ABIN2005505 : Holsinger, Ward, Duffield, Zachwieja, Jallal: The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn). in Oncogene 2002 (PubMed)

More Proteins for PTPRJ Interaction Partners

Human Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) interaction partners

  1. the combination of CD200 (show CD200 Proteins) and CD148 may have a potential differential diagnostic value in leukemic B-CLPDs, especially between CLL and MCL (show FH Proteins).

  2. These results demonstrated Ptprj as a physiological enzyme that attenuates insulin (show INS Proteins) signalling in vivo, and indicate that an inhibitor of Ptprj may be an insulin (show INS Proteins)-sensitizing agent.

  3. CD148 tyrosine phosphatase promotes e-cadherin (show CDH1 Proteins) cell adhesion.

  4. The studies suggest induction of MMP-9 (show MMP9 Proteins) expression promoted by DEP-1 deficiency.

  5. Moderate expression of DEP-1 was associated with the increased relapse.

  6. C33A cells lacking PTPRJ had increased cell viability, growth, migration, G1-S transition, and 5-FU resistance. PTPRJ negatively regulated the JAK1 (show JAK1 Proteins)/STAT3 (show STAT3 Proteins) pathway by decreasing phosphorylation levels of JAK1 (show JAK1 Proteins) and STAT3 (show STAT3 Proteins) and expression of downstream factors.

  7. The expression profiles of DEP1 and B2MG correlate with increased cell senescence and survival in breast cancer.

  8. Phosphorylation of T1318 is part of a regulatory mechanism that channels the activity of DEP-1 towards Src (show SRC Proteins) to allow its optimal activation and the promotion of endothelial cell permeability.

  9. Data indicate that CD148 is upregulated in macrophages and T cells in rheumatoid arthritis (RA) samples, and its activity is enhanced by treatment with tumour necrosis factor alpha (TNFalpha), and reduced by synovial fluid or oxidising conditions.

  10. our data support the notion of DEP-1 as positive functional regulator in vascular cerebral arteriogenesis, involving differential PDGF-B (show PDGFB Proteins) gene expression.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ) interaction partners

  1. These results demonstrated Ptprj as a physiological enzyme that attenuates insulin (show INS Proteins) signalling in vivo, and indicate that an inhibitor of Ptprj may be an insulin (show INS Proteins)-sensitizing agent.

  2. DEP-1 acts as an endogenous antagonist of the insulin receptor (show INSR Proteins), and downregulation of DEP-1 results in an improvement of insulin (show INS Proteins) sensitivity.

  3. Data indicate that CD148 mRNA is upregulated in diseased joints of with collagen-induced arthritis.

  4. The large ectodomains of CD45 and CD148 modulate their inhibitory effect by enabling their passive, size-based segregation from ligated TCR, supporting the kinetic-segregation model of TCR triggering.

  5. phosphatase CD148 promotes airway hyperresponsiveness through SRC (show SRC Proteins) family kinases

  6. These data indicate that PTPRJ may regulate differentiation of normal mammary epithelia and that dysregulation of protein localisation may be associated with tumorigenesis.

  7. CD148 plays a dominant role in activating Src (show SRC Proteins) family kinases in platelets relative to PTP-1B (show PTPN1 Proteins). Both PTPs (show PTS Proteins) are required for optimal platelet activation and aggregate formation under high arterial shear rates.

  8. CD45 and CD148 preferentially target different SFK members (Hck and Fgr versus Lyn, respectively) to positively and negatively regulate GPCR pathways.

  9. differential effects of CD148 in T cells and other leukocyte subsets

  10. DEP-1 is negatively regulating FLT3 (show FLT3 Proteins) signaling activity and that its loss may contribute to but is not sufficient for leukemogenic cell transformation.

PTPRJ Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PTPRJ

  • protein tyrosine phosphatase, receptor type, J (Ptprj)
  • protein tyrosine phosphatase, receptor type, J (PTPRJ)
  • protein tyrosine phosphatase, receptor type, J (EUBREC_2762)
  • protein tyrosine phosphatase, receptor type, J (LOC100219143)
  • protein tyrosine phosphatase, receptor type, J (LOC100347798)
  • AI450271 protein
  • BET protein
  • Byp protein
  • CD148 protein
  • DEP-1 protein
  • DEP1 protein
  • HPTPeta protein
  • Ptpb2 protein
  • PTPbeta2 protein
  • PTPRJ protein
  • R-PTP-ETA protein
  • RPTPJ protein
  • Scc-1 protein
  • Scc1 protein

Protein level used designations for PTPRJ

receptor-type tyrosine-protein phosphatase eta , density enhanced phosphatase-1 , protein tyrosine phosphatase, receptor type, J , receptor-type tyrosine-protein phosphatase eta-like , CD148 antigen , DEP-1 , HPTP eta , R-PTP-J , density-enhanced phosphatase 1 , human density enhanced phosphatase-1 , protein tyrosine phosphatase, receptor type, J polypeptide , protein-tyrosine phosphatase eta , protein-tyrosine phosphatase receptor type J , susceptibility to colon cancer 1, mouse, homolog of , HPTP beta-like tyrosine phosphatase , R-PTP-eta , colon tumor susceptibility 1 , susceptibility to colon cancer 1 , supporting-cell antigen

GENE ID SPECIES
29645 Rattus norvegicus
451181 Pan troglodytes
483617 Canis lupus familiaris
527664 Bos taurus
7964783 Eubacterium rectale ATCC 33656
100058689 Equus caballus
100082831 Ornithorhynchus anatinus
100219143 Taeniopygia guttata
100347798 Oryctolagus cuniculus
100401167 Callithrix jacchus
100484047 Ailuropoda melanoleuca
5795 Homo sapiens
19271 Mus musculus
395330 Gallus gallus
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