OPTN antibody (AA 341-440)
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- Target See all OPTN Antibodies
- OPTN (Optineurin (OPTN))
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Binding Specificity
- AA 341-440
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This OPTN antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human, Mouse
- Predicted Reactivity
- Rat,Cow,Sheep
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Optineurin
- Isotype
- IgG
- Top Product
- Discover our top product OPTN Primary Antibody
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anti-Optineurin (OPTN) (AA 1-300) antibody
OPTN Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Optineurin (OPTN) antibodyOPTN Reactivity: Human WB, IP, IHC (p), IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-577) antibodyOPTN Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-577) antibodyOPTN Reactivity: Human WB, IHC, IP Host: Rabbit Polyclonal unconjugated
anti-Optineurin (OPTN) antibodyOPTN Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 1-577) antibodyOPTN Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 575-591) antibodyOPTN Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 559-575) antibodyOPTN Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Optineurin (OPTN) (AA 71-96) antibodyOPTN Reactivity: Human WB Host: Rabbit Polyclonal RB21453 unconjugated
anti-Optineurin (OPTN) (C-Term) antibodyOPTN Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Monkey WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- OPTN (Optineurin (OPTN))
- Alternative Name
- Optineurin (OPTN Products)
- Synonyms
- nrp antibody, fip2 antibody, hip7 antibody, hypl antibody, glc1e antibody, tfiiia-intp antibody, ALS12 antibody, FIP2 antibody, GLC1E antibody, HIP7 antibody, HYPL antibody, NRP antibody, TFIIIA-INTP antibody, Fip2 antibody, 4930441O07Rik antibody, fj52f04 antibody, si:ch211-240l19.3 antibody, wu:fj52f04 antibody, zgc:66386 antibody, zgc:77868 antibody, optineurin antibody, optineurin L homeolog antibody, OPTN antibody, optn antibody, Optn antibody, optn.L antibody
- Background
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Synonyms: NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP, Optineurin, E3-14.7K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, OPTN
Background: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR), regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family, targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
- Gene ID
- 10133
- UniProt
- Q96CV9
- Pathways
- M Phase
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