ARFGEF2 antibody (AA 200-317)
-
- Target See all ARFGEF2 Antibodies
- ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))
-
Binding Specificity
- AA 200-317
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This ARFGEF2 antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 protein (200-317AA)
- Isotype
- IgG
-
-
- Application Notes
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))
- Alternative Name
- ARFGEF2 (ARFGEF2 Products)
- Synonyms
- AI463430 antibody, AW493672 antibody, BIG2 antibody, E230011G24Rik antibody, Big2 antibody, PVNH2 antibody, dJ1164I10.1 antibody, ADP ribosylation factor guanine nucleotide exchange factor 2 antibody, ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) antibody, ARFGEF2 antibody, Arfgef2 antibody
- Background
-
Background: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles, the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.
Aliases: ARFGEF2 antibody, ARFGEP2 antibody, BIG2Brefeldin A-inhibited guanine nucleotide-exchange protein 2 antibody, Brefeldin A-inhibited GEP 2 antibody, ADP-ribosylation factor guanine nucleotide-exchange factor 2 antibody
- UniProt
- Q9Y6D5
-