LRRN1 Protein (AA 26-631) (His tag)
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- Target See all LRRN1 Proteins
- LRRN1 (Leucine Rich Repeat Neuronal 1 (LRRN1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 26-631
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LRRN1 protein is labelled with His tag.
- Purpose
- Mouse LRRN1 Protein
- Sequence
- Ser26-Ala631
- Characteristics
- Recombinant Mouse LRRN1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser26-Ala631.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- LRRN1 (Leucine Rich Repeat Neuronal 1 (LRRN1))
- Alternative Name
- LRRN1 (LRRN1 Products)
- Synonyms
- lrrn1 Protein, nlrr-1 Protein, nlrr-6 Protein, figler3 Protein, xnlrr-1 Protein, MGC68868 Protein, XlNLRR-6 Protein, LRRN1 Protein, FIGLER3 Protein, NLRR-1 Protein, LRCH4 Protein, 2810047E21Rik Protein, leucine rich repeat neuronal 1 L homeolog Protein, leucine rich repeat neuronal 1 Protein, leucine rich repeat neuronal 1-like L homeolog Protein, leucine rich repeat neuronal 1-like Protein, leucine rich repeat protein 1, neuronal Protein, lrrn1.L Protein, lrrn1 Protein, lrrn1-like.L Protein, lrrn1-like Protein, LRRN1 Protein, Lrrn1 Protein
- Background
- Lrrn1 is required for the formation of MHB--loss of function leads to a loss of the morphological constriction and loss of Fgf8. Cells overexpressing Lrrn1 violate the boundary and result in a loss of cell restriction between midbrain and hindbrain compartments. Lrrn1 also regulates the glycosyltransferase Lunatic Fringe, a modulator of Notch signalling, maintaining its expression in midbrain cells which is instrumental in MHB boundary formation.
- Molecular Weight
- 69.28 kDa. Due to glycosylation, the protein migrates to 80-90 kDa based on Tris-Bis PAGE result.
- UniProt
- Q61809
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