For best experience we recommend to activate Javascript in your browser.

TRIM21 antibody (C-Term)

Name: TRIM21 antibody (C-Term)
SKU: ABIN6265729
Price: 390.77 USD
Availability: InStock

TRIM21 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

Western blot analysis of Hela whole cell lysates, using TRIM21 Antibody. (TRIM21 antibody (C-Term))

Western blot analysis of extracts from mouse brain, using TRIM21 Antibody. (TRIM21 antibody (C-Term))

ABIN6276980 at 1/200 staining human brain tissue sections by IHC-P. (TRIM21 antibody (C-Term))

IHC

3 images

Catalog No. ABIN6265729

Datasheet as PDF

Target See all TRIM21 Antibodies

TRIM21 (Tripartite Motif Containing 21 (TRIM21))
Binding Specificity
15

10

5

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
Reactivity
55

27

7

4

3

2

1

1

1

1

1
Human, Mouse, Rat
Host
49

8

2

1

1
Rabbit
Compatible Secondaries
Clonality
54

7
Polyclonal
Conjugate
39

5

3

3

1

1

1

1

1

1

1

1

1

1

1
This TRIM21 antibody is un-conjugated
Application
48

21

13

13

11

9

8

7

5

3

2

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity

TRIM21 Antibody detects endogenous levels of total TRIM21.

Purification

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen

A synthesized peptide derived from human TRIM21, corresponding to a region within C-terminal amino acids.

Isotype

IgG

Top Product

Discover our top product TRIM21 Primary Antibody
anti-Tripartite Motif Containing 21 (TRIM21) (AA 80-330) antibody
TRIM21 Reactivity: Human WB, IHC, IF, IP Host: Rabbit Polyclonal unconjugated

anti-Tripartite Motif Containing 21 (TRIM21) (C-Term) antibody
Verified TRIM21 Reactivity: Human WB, ELISA, IF, FACS Host: Goat Polyclonal unconjugated

anti-Tripartite Motif Containing 21 (TRIM21) antibody
TRIM21 Reactivity: Human WB, IF, IP, ICC, IHC (p) Host: Rabbit Polyclonal unconjugated

anti-Tripartite Motif Containing 21 (TRIM21) (AA 268-465) antibody
TRIM21 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Tripartite Motif Containing 21 (TRIM21) (AA 301-400) antibody
TRIM21 Reactivity: Human, Mouse WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-Tripartite Motif Containing 21 (TRIM21) (AA 1-475) antibody
TRIM21 Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated

anti-Tripartite Motif Containing 21 (TRIM21) (AA 1-475) antibody
TRIM21 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 2C9 unconjugated

anti-Tripartite Motif Containing 21 (TRIM21) (AA 1-475) antibody
TRIM21 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated

anti-Tripartite Motif Containing 21 (TRIM21) (AA 68-175) antibody
TRIM21 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated

anti-Tripartite Motif Containing 21 (TRIM21) (AA 1-475) antibody
TRIM21 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated

Application Notes

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date

12 months
Target

TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Alternative Name

TRIM21 (TRIM21 Products)

Synonyms

RNF81 antibody, RO52 antibody, SSA antibody, SSA1 antibody, Ro52 antibody, Ssa1 antibody, tripartite motif containing 21 antibody, tripartite motif-containing 21 antibody, TRIM21 antibody, Trim21 antibody

Background

Description: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).
Gene: TRIM21

Molecular Weight

54kDa

Gene ID

6737

UniProt

P19474