This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This AP3M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human AP3M1.
1200013D09Rik antibody, C78982 antibody, R75378 antibody, P47a antibody, adaptor related protein complex 3 mu 1 subunit antibody, adaptor-related protein complex 3, mu 1 subunit antibody, AP3M1 antibody, Ap3m1 antibody
Background
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed.