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RFWD3 antibody

RFWD3 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7118631
  • Target See all RFWD3 Antibodies
    RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))
    Reactivity
    Human, Mouse, Rat
    Host
    • 18
    • 2
    Rabbit
    Clonality
    • 18
    • 2
    Polyclonal
    Conjugate
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RFWD3 antibody is un-conjugated
    Application
    • 11
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    ring finger and WD repeat domain 3
    Isotype
    IgG
    Top Product
    Discover our top product RFWD3 Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))
    Alternative Name
    RFWD3 (RFWD3 Products)
    Synonyms
    RGD1305243 antibody, RFWD3 antibody, RNF201 antibody, BC027246 antibody, ring finger and WD repeat domain 3 antibody, Rfwd3 antibody, RFWD3 antibody
    Background
    Synonyms:RNF201 Background:E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
    Molecular Weight
    85 kDa
    Gene ID
    55159
    UniProt
    Q6PCD5
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