DNA Repair Protein Homolog 1 (RAD51) (N-Term) Peptide
RAD51
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all RAD51 products
- RAD51 (DNA Repair Protein Homolog 1 (RAD51))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-RAD51 antibody (Catalog #: ARP33450_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RAD51 (DNA Repair Protein Homolog 1 (RAD51))
- Synonyms
- BRCC5 Peptide, HRAD51 Peptide, HsRad51 Peptide, HsT16930 Peptide, MRMV2 Peptide, RAD51A Peptide, RECA Peptide, CRAD51 Peptide, wu:fb38e12 Peptide, zgc:77754 Peptide, RGD1563603 Peptide, ATRAD51 Peptide, F22D1.20 Peptide, F22D1_20 Peptide, RAS associated with diabetes protein 51 Peptide, AV304093 Peptide, Rad51a Peptide, Reca Peptide, brcc5 Peptide, rad51 Peptide, rad51a Peptide, reca Peptide, xrad51 Peptide, RAD51 recombinase Peptide, RAS associated with diabetes protein 51 Peptide, RAD51 recombinase L homeolog Peptide, RAD51 Peptide, rad51 Peptide, Rad51 Peptide, rad51.L Peptide
- Background
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RAD51 is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.
Alias Symbols: BRCC5, HRAD51, HsRad51, HsT16930, RAD51A, RECA
Protein Interaction Partner: E2F1,E2F4,BLM,BRCA1,BRCA2,BRCA1,BRCA2,ABL1,ATM,ATRX,BCCIP,BLM,BRCA1,BRCA2,C17orf28,CASP3,CASP7,CHD3,CHEK1,DMC1,DNAJA3,ERCC2,FANCD2,IRS1,RAD51,RAD51AP1,RAD51AP2,RAD51C,RAD52,RAD54B,RAD54L,RPA1,SUMO1,TP53,UBE2I,VIM,ABL1,ATM,ATRAD51,ATRX,BARD1,BLM,BRCA1,BRCA2,BRCA2,BRCA2(IV),BRCC3,BRE,CAB39,CHD3,CHEK1,DMC1,DNAJA3,H2AFX,LGTN,MCPH1,MSH4,RAD18,RAD51,RAD51AP1,RAD51C,RAD51L1,RAD51L3,RAD52,RAD54B,RPA1,SUMO1,TIMM13,TP53,UBE2I,VIM,XRCC2,XRCC3,tax
Protein Size: 242 - Molecular Weight
- 26 kDa
- Gene ID
- 5888
- NCBI Accession
- NM_133487, NP_597994
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