This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This Natriuretic Peptide Receptor A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Natriuretic Peptide Receptor A.
NPR1
Reactivity: Human
ELISA
Host: Rabbit
Polyclonal
HRP
Application Notes
IHC-P: 1:10~50
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid freeze-thaw cycles.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date
6 months
Abdelalim, Masuda, Tooyama: "Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina." in: Peptides, Vol. 29, Issue 4, pp. 622-8, (2008) (PubMed).
Dams, Van Acker, Gustin, Vereycken, Bunkens, Holemans, Smeulders, Clayton, Ohagen, Hertogs: "A time-resolved fluorescence assay to identify small-molecule inhibitors of HIV-1 fusion." in: Journal of biomolecular screening, Vol. 12, Issue 6, pp. 865-74, (2007) (PubMed).
Tomescot, Leschik, Bellamy, Dubois, Messas, Bruneval, Desnos, Hagège, Amit, Itskovitz, Menasché, Pucéat: "Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 9, pp. 2200-5, (2007) (PubMed).
Target
NPR1
(Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))
Alternative Name
Natriuretic Peptide Receptor A (NPR1/ANPA) (NPR1 Products)
ANPA is a receptor for atrial natriuretic peptide. It exhibits guanylate cyclase activity on binding of ANF. There seem to be at least three ANP receptors: two with guanylate cyclase activity (ANPA and ANPB) and one (ANPC) which is probably responsible for the clearance of ANP from the circulation without a role in signal transduction. This Type I membrane protein belongs to the adenylyl cyclase class-4/guanylyl cyclase family and contains 1 protein kinase-like domain.