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PITX3 antibody (AA 10-200)

PITX3 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7163469
  • Target See all PITX3 Antibodies
    PITX3 (Pituitary Homeobox 3 (PITX3))
    Binding Specificity
    • 15
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 10-200
    Reactivity
    • 25
    • 22
    • 21
    • 19
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    Human
    Host
    • 37
    • 1
    Rabbit
    Clonality
    • 37
    • 1
    Polyclonal
    Conjugate
    • 14
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PITX3 antibody is un-conjugated
    Application
    • 26
    • 13
    • 13
    • 10
    • 7
    • 5
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human, Mouse
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Pituitary homeobox 3 protein (10-200AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    PITX3 (Pituitary Homeobox 3 (PITX3))
    Alternative Name
    PITX3 (PITX3 Products)
    Synonyms
    CTPP4 antibody, CTRCT11 antibody, PTX3 antibody, pitx3 antibody, Ptx3 antibody, ak antibody, zgc:109716 antibody, pitx3-A antibody, xPitx3 antibody, paired like homeodomain 3 antibody, paired-like homeodomain 3 antibody, paired like homeodomain 3 L homeolog antibody, paired-like homeodomain transcription factor 3 antibody, paired-like homeodomain transcription factor Pitx3 antibody, PITX3 antibody, Pitx3 antibody, pitx3.L antibody, pitx3 antibody
    Background

    Background: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).

    Aliases: Homeobox protein PITX 3 antibody, Homeobox protein PITX3 antibody, MGC12766 antibody, Paired like homeodomain transcription factor 3 antibody, Paired-like homeodomain transcription factor 3 antibody, Pituitary homeobox 3 antibody, PITX 3 antibody, Pitx3 antibody, PITX3_HUMAN antibody, PTX 3 antibody, PTX3 antibody

    UniProt
    O75364
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