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WDR24 antibody (AA 1-298)

WDR24 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7153705
  • Target See all WDR24 products
    WDR24 (WD Repeat Domain 24 (WDR24))
    Binding Specificity
    • 3
    • 1
    AA 1-298
    Reactivity
    • 7
    • 1
    Human
    Host
    • 7
    Rabbit
    Clonality
    • 7
    Polyclonal
    Conjugate
    • 4
    • 1
    • 1
    • 1
    This WDR24 antibody is un-conjugated
    Application
    • 4
    • 4
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human GATOR complex protein WDR24 protein (1-298AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:200-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    WDR24 (WD Repeat Domain 24 (WDR24))
    Alternative Name
    WDR24 (WDR24 Products)
    Synonyms
    C16orf21 antibody, JFP7 antibody, BC037651 antibody, wu:fd05f12 antibody, zgc:55946 antibody, WD repeat domain 24 antibody, WD repeat domain 24 L homeolog antibody, WDR24 antibody, Wdr24 antibody, wdr24 antibody, wdr24.L antibody
    Background

    Background: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).

    Aliases: C16orf21 antibody, DKFZp434F054 antibody, JFP7 antibody, LA16c-313D11.2 antibody, WD repeat-containing protein 24 antibody, wdr24 antibody, WDR24_HUMAN antibody

    UniProt
    Q96S15
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