DOC2A antibody (AA 652-749)
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- Target See all DOC2A Antibodies
- DOC2A (Double C2-Like Domains, alpha (DOC2A))
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Binding Specificity
- AA 652-749
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This DOC2A antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human DOC2 (AA: 652-749) expressed in E. coli.
- Clone
- 2H7C4
- Isotype
- IgG1
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: , ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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- Target
- DOC2A (Double C2-Like Domains, alpha (DOC2A))
- Alternative Name
- DOC2 (DOC2A Products)
- Synonyms
- DOC2A antibody, doc2-A antibody, Doc2 antibody, double C2 domain alpha antibody, double C2-like domains, alpha antibody, double C2, alpha antibody, DOC2A antibody, doc2a antibody, Doc2a antibody
- Background
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Description: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,
Aliases: DAB2, DOC-2
- Molecular Weight
- 82.4 kDa
- Gene ID
- 1601
- HGNC
- 5899
- Pathways
- Synaptic Vesicle Exocytosis
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