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Human Polyclonal DNAJC3 Primary Antibody for IF (p), IHC (p) - ABIN735548
Taguchi, Allende, Mizukami, Cook, Gavrilova, Tuymetova, Clarke, Chen, Olivera, Proia: Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation. in The Journal of biological chemistry 2016
Human Monoclonal DNAJC3 Primary Antibody for IF, ELISA - ABIN562442
Roobol, Roobol, Bastide, Knight, Willis, Smales: p58IPK is an inhibitor of the eIF2? kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. in The Biochemical journal 2015
p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis
Loss-of-function DNAJC3 mutations lead to a monogenic, recessive form of diabetes mellitus in humans.
p58 (show CDK11B Antibodies)(IPK) suppresses coxsackievirus B3-induced apoptosis through selective activation of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway that requires activation of ATF6a (show ATF6 Antibodies) and subsequently upregulates mitofusin 2 (show MFN2 Antibodies).
interplay between p38 (show CRK Antibodies) phosphorylation and p58 (show CDK11B Antibodies)(IPK) upregulation has key roles in modulating ERp29 (show ERP29 Antibodies)-induced cell-growth arrest and survival
the crystal structure of human P58 (show CDK11B Antibodies)(IPK)
Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP (show DDIT3 Antibodies) and SREBP1 (show SREBF1 Antibodies).
Spleen cells from transgenic mice overexpressing (Hu)PKR (show PKLR Antibodies) were studied and compared to those from wild-type mice after drug treatment. Dact (show Actbeta Antibodies)-treated spleen cells were resistant to apoptosis; ConA-treated cells had decreased cell division.
P58 (show CDK11B Antibodies)(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha (show EIF2A Antibodies) signaling, and thus attenuate the unfolded protein response.
The study demonstrates that P58 (show CDK11B Antibodies)(IPK) inhibits endoplasmic reticulum (ER) stress and plays an important role in maintaining balance and stability of the ER in human retinal capillary endothelial cells.
Cloning, prokaryotic expression of novel swine gene P58IPK and its polyclonal antibody preparation
Chaperone protein p58 (show CDK11B Antibodies)(IPK) is expressed predominantly in retinal ganglion cells (RGC), inner retinal neurons, and the photoreceptor inner segments.
combined deletion of ATF6alpha (show ATF6 Antibodies) and the ER cochaperone p58 (show CDK11B Antibodies)(IPK) resulted in synthetic embryonic lethality.
Data present a working model for P58 (show CDK11B Antibodies)(IPK) to act together with Bip (show HSPA5 Antibodies) to prevent protein aggregations and promote protein foldings within ER.
mechanism by which P58 (show CDK11B Antibodies)(IPK) functions to promote protein folding within the endoplasmic reticulum, determined from the crystal structure of P58 (show CDK11B Antibodies)(IPK)
renal injury inflicted by expression of the folding mutants was markedly enhanced by haploinsufficiency of the endoplasmic reticulum cochaperone p58 (show CDK11B Antibodies)(IPK).
The stress of unfolded proteins in the ER activates P58(IPK) transcription through an ER stress-response element in its promoter. P58(IPK) interacts with & inhibits PERK, which protects cells during the ER-stress response by reducing protein synthesis.
Insulin (show INS Antibodies) deficiency associated with the absence of P58 (show CDK11B Antibodies)(IPK) mimics beta-cell failure associated with type 1 and late-stage type 2 diabetes.
absence of P58 (show CDK11B Antibodies)(IPK) led to an increase in eIF2alpha (show EIF2A Antibodies) phosphorylation and decreased influenza virus mRNA translation
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).
dnaJ homolog subfamily C member 3
, DnaJ (Hsp40) homolog, subfamily C, member 3
, Interferon-induced, double-stranded RNA-activated protein kinase inhibitor
, TPR repeat-containing protein
, endoplasmic reticulum DnaJ protein 6
, interferon-induced, double-stranded RNA-activated protein kinase inhibitor
, protein kinase inhibitor of 58 kDa
, protein kinase inhibitor p58
, protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
, DnaJ (Hsp40) homolog, subfamily C, member 3A
, DnaJ (Hsp40) homolog, subfamily C, member 3B
, protein kinase, interferon inducible double stranded RNA dependent inhibitor