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Study reports that the endoplasmic reticulum luminal co-chaperone ERdj4/DNAJB9 (show DNAJB9 ELISA Kits) is a selective IRE1 repressor that promotes a complex between the luminal Hsp70 (show HSP70 ELISA Kits) BiP (show GDF10 ELISA Kits) and the luminal stress-sensing domain of IRE1alpha.
The present study is the first to uncover a key prosurvival modulator, Yip1A, which coordinates IRE1 signaling with PERK signaling to support the survival of HeLa and CaSki cervical cancer cells.
Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels.
Overall, these data demonstrate that hypoxia can suppress adiponectin expression and activate the PERK and IRE1 signaling pathways in differentiated adipocytes, and this two pathways are involved in the suppression of adiponectin expression induced by hypoxia.
ER stress-regulated IRE1 dependent decay is involved in regulation of hepatic diseases. (review)
The unfolded protein response reduces glucose metabolism via IRE1 signaling.
Results of this investigation demonstrate that inhibition of IRE1 signaling enzyme function affects the expression of NRIP1 (show NRIP1 ELISA Kits), EBBP (show TRIM16 ELISA Kits), ESRRA (show ESRRA ELISA Kits), E2IG5 (show FAM162A ELISA Kits), PGRMC2 (show PGRMC2 ELISA Kits), and SLC39A6 (show SLC39A6 ELISA Kits) genes in U87 glioma cells in gene specific manner and these changes possibly contribute to the suppression of the cell proliferation. Most of these genes are regulated by hypoxia and preferentially through IRE1 signaling pathway of endoplasmic reticulum stress
IRE1alpha was shown to cleave miR (show MLXIP ELISA Kits)-150 and thereby to release the suppressive effect that miR (show MLXIP ELISA Kits)-150 exerted on alphaSMA (show ACTA2 ELISA Kits) expression through c-Myb (show MYB ELISA Kits). Inhibition of IRE1alpha was also demonstrated to block endoplasmic reticulum expansion through an XBP-1 (show XBP1 ELISA Kits)-dependent pathway.
IRE-1 has an ancient function as a cytoplasmic sentinel that activates p38 (show CRK ELISA Kits) and SKN-1(Nrf2 (show GABPA ELISA Kits)). csteine modifications induced by ROS (show ROS1 ELISA Kits) signals can direct proteins to adopt unexpected functions and may coordinate many cellular processes.
The findings indicate that IRE1-XBP1 (show XBP1 ELISA Kits) downregulation distinguishes germinal center B-cell-like diffuse large B-cell lymphoma (DLBCL) from other DLBCL subtypes and contributes to tumor growth.
IRE1alpha has a critical role in colonic tumorigenesis and IRE1alpha targeting might be a strategy for treatment of colon cancers.
Study provided the first link between energy homeostasis, lipid metabolism and pro-opiomelanocortin (POMC (show POMC ELISA Kits)) neuronal IRE1alpha function. The effects of POMC (show POMC ELISA Kits) IRE1alpha knockout were mediated via increased thermogenesis, possibly caused by the increased alpha-MSH production in the hypothalamus. These results demonstrate that IRE1alpha in POMC (show POMC ELISA Kits) neurons plays a critical role in the regulation of obesity and obesity-related m...
Data show that LPS (show TLR4 ELISA Kits) induces endoplasmic reticulum (ER) stress and P300 (show NOTCH1 ELISA Kits) activity via the XBP1 (show XBP1 ELISA Kits)/IRE1 pathway.
cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner.
Data suggest that activation of GRP78 (show HSPA5 ELISA Kits)/Ire1/Xbp1 (show XBP1 ELISA Kits) pathway of ER stress-unfolded protein response is involved in mouse decidualization.
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.
defective autophagy in intestinal epithelial cells (IECs) may predispose to Crohn's disease ileitis via impaired clearance of IRE1alpha aggregates during ER stress at this site.
the ABL (show ABL1 ELISA Kits) family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis.
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.
ER to nucleus signalling 1
, endoplasmic reticulum-to-nucleus signaling 1
, inositol-requiring 1
, inositol-requiring enzyme 1
, inositol-requiring protein 1
, protein kinase/endoribonuclease
, serine/threonine-protein kinase/endoribonuclease IRE1
, endoplasmic reticulum to nucleus signalling 1
, inositol-requiring 1 alpha
, endoplasmic reticulum (ER) to nucleus signalling 1
, endoplasmic reticulum-to-nucleus signaling 2
, inositol-requiring 1 (Yeast homologue)
, inositol-requiring 1 beta
, inositol-requiring protein 2
, serine/threonine-protein kinase/endoribonuclease IRE2
, endoplasmic reticulum to nucleus signaling 1