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FK506 Binding Protein 14, 22 KDa Proteins (FKBP14)
On www.antibodies-online.com are 13 FK506 Binding Protein 14, 22 KDa (FKBP14) Proteins from 8 different suppliers available. Additionally we are shipping FK506 Binding Protein 14, 22 KDa Antibodies (53) and many more products for this protein. A total of 72 FK506 Binding Protein 14, 22 KDa products are currently listed.
Synonyms:
BC029109, EDSKMH, FKBP-14, FKBP22, IPBP12, MGC81908, MGC89927
list all proteins Gene Name GeneID UniProt
FKBP14 231997 P59024
FKBP14 55033 Q9NWM8
FKBP14    

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FK506 Binding Protein 14, 22 KDa Proteins (FKBP14) by Origin

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Top referenced FK506 Binding Protein 14, 22 KDa Proteins

  1. Human FKBP14 Protein expressed in Human Cells - ABIN2005768 : Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003 (PubMed)
    Show all 3 references for 2005768

  2. Human FKBP14 Protein expressed in Escherichia coli (E. coli) - ABIN667027 : Budiman, Bando, Angkawidjaja, Koga, Takano, Kanaya: Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase. Importance of a V-shaped dimeric structure for binding to protein substrate. in The FEBS journal 2009 (PubMed)
    Show all 2 references for 667027

More Proteins for FK506 Binding Protein 14, 22 KDa Interaction Partners

Human FK506 Binding Protein 14, 22 KDa (FKBP14) interaction partners

  1. observed changes in activity of six rER-resident PPIases, cyclophilin B (show PPIB Proteins) (encoded by the PPIB (show PPIB Proteins) gene), FKBP13 (FKBP2 (show FKBP2 Proteins)), FKBP19 (FKBP11 (show FKBP11 Proteins)), FKBP22 (FKBP14), FKBP23 (FKBP7 (show FKBP7 Proteins)), and FKBP65 (FKBP10 (show FKBP10 Proteins)), due to posttranslational modifications of proline residues in the substrate.

  2. FKBP14 expression was elevated in ovarian cancer tissues when compared with matched normal tissues. Lentiviral shRNA mediated knockdown of FKBP14 and suppressed the growth of ovarian cancer cells via arresting the cell cycle in the G0/G1 phase and stimulating cell apoptosis. Moreover, cell apoptosis induced by FKBP14 RNAi was mediated by enhancing the ratio of Bax (show BAX Proteins)/Bcl-2 (show BCL2 Proteins).

  3. Reduced expression of FKBP14 markedly impaired the proliferative ability of ovarian cancer cells. Additionally, ovarian cancer cells infected with FKBP14 shRNA lentivirus tended to arrest in the G0/G1 phase and undergo apoptosis.

  4. the occurrence of umbilical skin redundancy in association with two other syndromes: Morquio syndrome and FKBP14-related Ehlers-Danlos syndrome (EDS), is reported.

  5. FKBP22 catalyzes the folding of type III collagen (show COL3A1 Proteins) and only interacts with type III type VI and type X collagen.

  6. A 1.9 A resolution crystal structure for human FKBP22 has been determined. The EF-hand motifs of two FKBP22 molecules form a dimeric complex with an elongated and predominantly hydrophobic cavity that can potentially be occupied by an aliphatic ligand.

  7. study demonstrated FKBP14 is localized in the endoplasmic reticulum (ER) and that deficiency of FKBP14 leads to enlarged ER cisterns in dermal fibroblasts in vivo.

FK506 Binding Protein 14, 22 KDa (FKBP14) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene.

Alternative names and synonyms associated with FK506 Binding Protein 14, 22 KDa (FKBP14)

  • FK506 binding protein 14, 22 kDa (FKBP14)
  • FK506 binding protein 14, 22 kDa (fkbp14)
  • FK506 binding protein 14, 22 kDa (LOC100228355)
  • FK506 binding protein 14 (Fkbp14)
  • BC029109 protein
  • EDSKMH protein
  • FKBP-14 protein
  • FKBP22 protein
  • IPBP12 protein
  • MGC81908 protein
  • MGC89927 protein

Protein level used designations for FKBP14

FK506 binding protein 14, 22 kDa , FK506-binding protein 14 , PPIase FKBP14 , peptidyl-prolyl cis-trans isomerase FKBP14 , rotamase , 22 kDa FK506-binding protein , 22 kDa FKBP , FKBP-22

GENE ID SPECIES
420636 Gallus gallus
444769 Xenopus laevis
448687 Xenopus (Silurana) tropicalis
463324 Pan troglodytes
611546 Canis lupus familiaris
696247 Macaca mulatta
100228355 Taeniopygia guttata
231997 Mus musculus
55033 Homo sapiens
100174527 Pongo abelii
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