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These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1 (show KEAP1 Proteins), disrupting the Keap1 (show KEAP1 Proteins)-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.
These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.
we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Proteins) and JNK (show MAPK8 Proteins)/Nrf2/NQO1 (show NQO1 Proteins) pathway.
Bach1 (show BACH1 Proteins) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Proteins) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Proteins) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Proteins) gene expression in aortic endothelial cells by advanced glycation end products
Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
Obacunone activates the Nrf2 (show GABPA Proteins)-dependent antioxidant responses.
These findings indicate a single session of submaximal aerobic exercise is sufficient to activate Nrf2 (show GABPA Proteins) at the whole cell level in both young and older adults, but that nuclear import is impaired with aging. Additionally we have shown repressed gene expression of downstream antioxidant targets of Nrf2 (show GABPA Proteins) in older adults.
Authors explored the expression and signaling pathway of a master player of the anti-oxidant and anti-inflammatory response, namely NF-E2-related Factor 2, in muscle biopsies of DMD (show DMD Proteins) patients.
our study pinpoints that PAQR3 (show PAQR3 Proteins) functions as an adaptor protein to promote Nrf2 (show GABPA Proteins)-Keap1 (show KEAP1 Proteins) complex formation, thereby modulating the Nrf2 (show GABPA Proteins)-Keap2 pathway and playing an important role in controlling antioxidant response of the cell
SNUC5/5-FUR cells are under oxidative stress, which induces expression of histone methylation-related proteins as well as DNA demethylase (show MBD2 Proteins), leading to upregulation of Nrf2 (show GABPA Proteins) and 5-FU resistance
Nrf2 (show GABPA Proteins) contributes to the protective effect of mild thermotolerance (40 degrees C) against heat shock-induced apoptosis.
Overexpression of NF-E2-related factor 2 (Nrf2) alone resulted in increased cell proliferation in pancreatic ductal adenocarcinoma (PDAC) cell lines BxPC-3 and AsPC-1.
Nrf2 (show GABPA Proteins)-mediated lncRNA ODRUL was indispensable for silver nanoparticle-induced toxicity in erythroid cells.
CAL (show FBLIM1 Proteins) suppresses the expression of pro-inflammatory cytokines via p62 (show GTF2H1 Proteins)/Nrf2 (show GABPA Proteins)-linked HO-1 (show HMOX1 Proteins) induction in RASFs.
Our results identified ECG as a novel Keap1 (show KEAP1 Proteins)-Nrf2 (show GABPA Proteins) interaction disruptor and LPS (show IRF6 Proteins)-induced TLR4 (show TLR4 Proteins) activation inhibitor, thereby providing an innovative strategy to prevent or treat immune, oxidative stress and inflammatory-related diseases
YZH-106 induced p38 MAPK (show MAPK14 Proteins) and ERK1/2 phosphorylation, which led to the activation of erythroid 2-related factor 2 (Nrf2) that up-regulated heme oxygenase-1 (HO-1 (show HMOX1 Proteins)) expression in addition to other genes.
Ltbp4 regulates Pdgfrb (show PDGFRB Proteins) expression via TGFbeta (show TGFB1 Proteins)-dependent modulation of Nrf2 transcription factor function.
a new role for nuclear factor erythroid-derived 2-like 2 (Nrf2) in regulating early anti-cancer immune responses by inducing IL-17D (show IL17D Proteins) and recruiting natural killer (NK) cells.
The results suggest that Nrf2 is an important regulator of the retinal milieu during tissue ischemia, and that the Nrf2/NOX2 (show CYBB Proteins) balance may play a critical role in determining the fate of ischemic revascularization.
Our results show for the first time that NO2-FA induce a potent Nrf2-dependent antioxidant response in astrocytes capable of preventing motor neurons death in a culture model of Amyotrophic Lateral Sclerosis.
Our results support that Nrf2 deletion produces mitochondrial dysfunction associated with mitochondrial permeabilization, increasing basal apoptosis through a caspase (show CASP3 Proteins)-independent and AIF (show AIFM1 Proteins)-dependent pathway
we demonstrate that RG induces HO-1 (show HMOX1 Proteins) expression by promoting phosphorylation of Nrf2 at Ser40 through activation of the ERK1/2 and JNK (show MAPK8 Proteins) cascade in macrophages.
Nonetheless, the decrements in mitochondrial function in Nrf2 KO muscle can be rescued by exercise training, suggesting that this restorative function operates via a pathway independent of Nrf2.
Daph exposure suppressed t-BHP-induced cytotoxicity and ROS (show ROS1 Proteins) overproduction, which are mostly blocked in Nrf2 knockout RAW 264.7 cells and peritoneal macrophages. Accordingly, Daph exhibited protective roles against t-BHP-triggered oxidative damage and mitochondrial dysfunction by the upregulation of Nrf2 antioxidant signaling pathways, which may be involved in the activation of JNK (show MAPK8 Proteins) and ERK (show EPHB2 Proteins)
Thus we propose that Cx43 (show GJA1 Proteins) might enhance the activation of Nrf2/ARE pathway by means of inhibiting c-Src (show SRC Proteins) activity to hinder the nuclear export of Nrf2, and then reduce expression of FN, ICAM-1 (show ICAM1 Proteins) and TGF-b1, ultimately attenuating renal fibrosis in diabetes.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2