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These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.
we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Proteins) and JNK (show MAPK8 Proteins)/Nrf2/NQO1 (show NQO1 Proteins) pathway.
Bach1 (show BACH1 Proteins) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Proteins) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Proteins) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Proteins) gene expression in aortic endothelial cells by advanced glycation end products
Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
Result showed that there was a significant association between Keap1 (show KEAP1 Proteins) and phosphorylated (p) Nrf2 (show GABPA Proteins) expression in hepatocellular carcinoma. Higher pNrf2 expression was more likely observed in those specimens with reduced Keap1 (show KEAP1 Proteins) expression.
NFE2L2 modulates autophagy gene expression and suggests a new strategy to combat proteinopathies.
Identify an Nrf2 (show GABPA Proteins)-mediated 17-gene signature, which reflects a cluster of gene ontology terms highly related to tuberculosis physiology.
Studies show that episodic exercise increase in oxidative stress stimulate Nrf2 (show GABPA Proteins) activation and when applied repeatedly leads to upregulation of endogenous antioxidant defenses. Nrf2 (show GABPA Proteins) activation in response to exercise across variety of tissues may be an important mechanism of how exercise exerts its well-known systemic effects that are not limited to skeletal muscle and myocardium. [review]
Nrf2 (show GABPA Proteins) Induces IL-17D (show IL17D Proteins) to mediate tumor and virus surveillance.
Study provides evidence that KEAP1 (show KEAP1 Proteins)/NRF2 (show GABPA Proteins) mutations increase radioresistance and predict local tumor recurrence in radiotherapy treated LSCC patients.
NFE2L2 genetic variant is associated with heart rate variability in obese patients.
Expression of either dominant-negative or constitutively active mutants of Nrf2 (show GABPA Proteins), ATF4 (show ATF4 Proteins), or c-Jun (show JUN Proteins) confirmed that distinct transcription units are regulated by these transcription factors.
Nrf2 (show GABPA Proteins)-driven TERT (show TERT Proteins) regulates pentose phosphate pathway in glioblastoma.
Nrf2 (show GABPA Proteins) inhibition in Dendritic Cells (DC) in glioma-exposed microenvironment could enhance the maturation of DCs and the subsequent activation of T cells and their cytotoxicity on glioma cells.
Nrf2 Induces IL-17D (show IL17D Proteins) to mediate tumor and virus surveillance.
Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 recruitment to the Srebp-1c (show SREBF1 Proteins) promoter in livers of BPA (show DST Proteins)-exposed mice was observed.
Novel transcriptional role of miR140-5p in the expression of Nrf2; miR (show MLXIP Proteins)-140-5p protected against Cisplatin induced oxidative stress by activating Nrf2-dependent antioxidant pathway, providing a potentially therapeutic target in acute kidney injury.
Saffron (Crocus sativus) protects against myocardial ischemia-reperfusion injury in Wild Type and ApoE (show APOE Proteins)((-/-)) mice via Nrf2 pathway.
High NRF2 expression is associated with Hepatocarcinogenesis.
Theraputic effects of Pirfenidone for induced pulmonary fibrosis were involved in Nrf2/Bach1 (show BACH1 Proteins) equilibrium which regulated the capacity of oxidative stress.
Nrf2-driven TERT (show TERT Proteins) regulates pentose phosphate pathway in glioblastoma.
Hyperactivation of Nrf2 in the initial phase of injury prevents the progression of reactive oxygen species-mediated tubular damage by inducing antioxidant enzymes and NADPH synthesis.
The results indicate that adipose-derived mesenchymal stem cells (ADSCs) can increase the survival of fat transplants through the modulation of inflammatory and oxidative responses via Nrf2 and TLR4 (show TLR4 Proteins), suggesting potential strategies to improve the use of ADSCs for cell therapy.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2