Browse our NRF2 Proteins (NFE2L2)

Full name:
Nuclear Factor (erythroid-Derived 2)-Like 2 Proteins (NFE2L2)
On are 10 Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) Proteins from 5 different suppliers available. Additionally we are shipping NRF2 Antibodies (211) and NRF2 Kits (32) and many more products for this protein. A total of 263 NRF2 products are currently listed.
AI194320, NF-E2R2, nfe2l2, NRF2, wu:fc15g09, wu:fj67e03
list all proteins Gene Name GeneID UniProt
NFE2L2 4780 Q16236
NFE2L2 18024 Q60795
NFE2L2 83619 O54968

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NRF2 Proteins (NFE2L2) by Origin

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More Proteins for NRF2 Interaction Partners

Zebrafish Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.

  2. we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity

  3. Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Proteins) and JNK (show MAPK8 Proteins)/Nrf2/NQO1 (show NQO1 Proteins) pathway.

  4. Bach1 (show BACH1 Proteins) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Proteins) inhibition based on its level in each tissue.

  5. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

  6. The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.

  7. oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.

  8. results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles

  9. compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds

  10. Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.

Cow (Bovine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Proteins) within these cells.

  2. the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.

  3. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Proteins) gene expression in aortic endothelial cells by advanced glycation end products

Pig (Porcine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.

  2. The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.

Human Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. examination of plant (show GABPA Proteins)ar skin b (show KRT16 Proteins)iopsies from individuals with pachyonychia congenita confirmed the presence of (show GABPA Proteins) high levels of hypophosphorylated NRF2 in lesional tissue

  2. SIRT2 (show SIRT2 Proteins) maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2 (show NFE2 Proteins)-related factor 2 (NRF2 (show GABPA Proteins)) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 (show GABPA Proteins) levels.

  3. basal function of NRF2 (show GABPA Proteins) in colorectal cancer

  4. NRF2 (show GABPA Proteins) is regulated at protein level by proteasomal degradation via KEAP1 (show KEAP1 Proteins). Data suggest that antioxidant-induced up-regulation of NRF2 (show GABPA Proteins) expression (a) overcomes KEAP1 (show KEAP1 Proteins) regulation, (b) activates NRF2 (show GABPA Proteins) translocation to nucleus, and (c) activates antioxidant response element. (NRF2 (show GABPA Proteins) = nuclear factor [erythroid-derived 2]-like 2 protein; KEAP1 (show KEAP1 Proteins) = Kelch-like ECH-associated protein 1 (show KEAP1 Proteins))

  5. The NRF2 (show GABPA Proteins)-overexpressing cell line, containing high levels of ABCF2 (show ABCF2 Proteins), was more resistant to cisplatin-induced apoptosis compared to its control ovarian cancer cell line; whereas the NRF2 (show GABPA Proteins) knockdown cell line with low levels of ABCF2 (show ABCF2 Proteins), was more sensitive to cisplatin treatment than its control cell line.

  6. findings demonstrate that Nrf2 (show GABPA Proteins) is a positive regulator of the NLRP3 (show NLRP3 Proteins) inflammasome.

  7. this review summarizes the recent findings about the chemoresistance-promoting role of NRF2 (show GABPA Proteins).

  8. IRE-1 (show ERN1 Proteins) has an ancient function as a cytoplasmic sentinel that activates p38 (show CRK Proteins) and SKN-1(Nrf2 (show GABPA Proteins)). csteine modifications induced by ROS (show ROS1 Proteins) signals can direct proteins to adopt unexpected functions and may coordinate many cellular processes.

  9. Our findings, together with the enhanced tumor formation and metastasis of xenografted mice by knockdown of the RBM47 expression, suggested tumor-suppressive roles for RBM47 through the inhibition of Nrf2 (show GABPA Proteins) activity

  10. Therefore, our findings suggested that overexpressing NRF2 (show GABPA Proteins) could be a potential method for maintaining stemness and preventing apoptosis in MSCs under oxidative stress.

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Hypoactivity of NRF2 in Krt16 (show KRT16 Proteins)-/- footpad skin correlated with decreased levels or activity of upstream NRF2 activators.

  2. Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease. Male mice were more sensitive than females.

  3. This study indicated that MAN can protect osteoblast against oxidative damage by modulation of ERK5 (show MAPK7 Proteins)/Nrf2 signaling, which can be new agent for osteoporosis.

  4. In conclusion, quercetin protected mice from d-galactose-induced cognitive functional impairment and neuronal cell apoptosis via activation of the Nrf2-ARE signaling pathway.

  5. Our results suggest that, during exercise, ROS (show ROS1 Proteins) and NO can act via NFE2L2 to functionally regulate skeletal muscle mitochondrial biogenesis and anti-oxidant defence gene expression

  6. findings demonstrate that Nrf2 is a positive regulator of the NLRP3 (show NLRP3 Proteins) inflammasome.

  7. This study showed that RANKL (show TNFSF11 Proteins) favors osteoclastogenesis via attenuation of Nrf2-mediated antioxidant enzyme expression by competing with Bach1 (show BACH1 Proteins) nuclear accumulation.

  8. Activation of the Nrf2 signaling pathway has been demonstrated to confer protection against environmental insults and prevent disease or inhibit the progression of diseases related to oxidative stress.

  9. examined the endogenous response of bone regulated by Nrf2, and its relationship with bone mass and architecture in the male and female skeleton

  10. formononetin (FMN (show FMN1 Proteins)) stimulated the expression of Nrf2 and antioxidant gene expression in the presence of Acetaminophen (APAP). These data provide an experimental basis for the use of FMN (show FMN1 Proteins) in the treatment of patients with APAP-induced hepatotoxicity.

NRF2 (NFE2L2) Protein Profile

Protein Summary

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NRF2 (NFE2L2)

  • nuclear factor (erythroid-derived 2)-like 2a (nfe2l2a)
  • nuclear factor (erythroid-derived 2)-like 2 (nfe2l2)
  • nuclear factor (erythroid-derived 2)-like 2 (NFE2L2)
  • nuclear factor, erythroid 2-like 2 (NFE2L2)
  • nuclear factor, erythroid derived 2, like 2 (Nfe2l2)
  • AI194320 protein
  • NF-E2R2 protein
  • nfe2l2 protein
  • NRF2 protein
  • wu:fc15g09 protein
  • wu:fj67e03 protein

Protein level used designations for NFE2L2

Nrf2a , nuclear factor (erythroid-derived 2)-like 2 , nuclear factor erythroid 2-related factor 2 , ECH , NF-E2-related factor 2 , NFE2-related factor 2 , nuclear factor, erythroid derived 2, like 2 , HEBP1 , nuclear factor erythroid-derived 2-like 2 , nrf2 , nuclear factor erythroid 2-like 2

360149 Danio rerio
444736 Xenopus laevis
396014 Gallus gallus
478813 Canis lupus familiaris
497024 Bos taurus
100516343 Sus scrofa
4780 Homo sapiens
18024 Mus musculus
83619 Rattus norvegicus
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