Browse our Eukaryotic Translation Initiation Factor 2C, 1 Proteins (EIF2C1)

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Eukaryotic Translation Initiation Factor 2C, 1 Proteins (EIF2C1)
On are 6 Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Proteins from 4 different suppliers available. Additionally we are shipping Eukaryotic Translation Initiation Factor 2C, 1 Antibodies (56) and many more products for this protein. A total of 68 Eukaryotic Translation Initiation Factor 2C, 1 products are currently listed.
Ago, Ago-1, ago1, ago1-1, anon-WO0257455.29, ARGONAUTE 1, CG6671, dAgo1, Dm Ago1, Dmel\\CG6671, DsimGD25729, dsim_GLEANR_9718, EIF2C, Eif2c1, GB12654, GD25729, GERP95, l(2)04845, l(2)4845, l(2)k00208, l(2)k08121, MRE20, Q99, T1N15.2, T1N15_2
list all proteins Gene Name GeneID UniProt
EIF2C1 26523 Q9UL18
Rat EIF2C1 EIF2C1 313594  
EIF2C1 236511 Q8CJG1

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Eukaryotic Translation Initiation Factor 2C, 1 Proteins (EIF2C1) by Origin

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Top referenced Eukaryotic Translation Initiation Factor 2C, 1 Proteins

  1. Human EIF2C1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004127 : Koesters, Adams, Betts, Moos, Schmid, Siermann, Hassam, Weitz, Lichter, Heitz, von Knebel Doeberitz, Briner: Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. in Genomics 1999 (PubMed)
    Show all 3 references for 2004127

More Proteins for Eukaryotic Translation Initiation Factor 2C, 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) interaction partners

  1. Results suggest that Wisp (show SNX9 Proteins) interacts with Ago1 and induces miRNA adenylation and facilitates its downregulation.

  2. Results have established a novel role of Ago-1 as a regulator of the cell cycle.

  3. AGO1 protein level is reduced in the absence of miRNA biogenesis & accumulates on depletion of GW182. Ectopic transcription of miRNAs within in vivo clones & genetic interference with the ubiquitin (show UBA52 Proteins)-proteasome system induced accumulation of AGO1.

  4. Smaug (show SAMD4A Proteins) directly recruits Ago1 to nanos mRNA in a miRNA-independent manner, thereby repressing translation.

  5. analysis of regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe

  6. The study provides a molecular explanation for the previously reported heterogeneity of miRNA 3' ends and proposes a model in which Nibbler converts miRNAs into isoforms that are compatible with the preferred length of Ago1-bound small RNAs.

  7. propose Drosophila Ago-1 as a multifunctional RNAi component that interconnects at least two unrelated events, chromatin organization in the nucleus and microRNA processing in the cytoplasm, which may be extended to the other systems

  8. these results suggest that Ago1 and its miRNA biogenesis partners play a role in oocyte determination and germline cell division in Drosophila.

  9. Ago1-RISC induces silencing via two independent pathways: shortening of the poly(A) tail and pure repression of translation

  10. Mutation of AGO2 (show EIF2C2 Proteins) or piwi (show PIWIL1 Proteins) increases silencing at piRNA clusters corresponding to an increase of HP1 (show CBX5 Proteins) association.

Silk Worm Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) interaction partners

  1. Ago1,Ago2,Ago3 and Piwi are upregulated upon infection with nucleopolyhedrovirus.

Pig (Porcine) Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) interaction partners

  1. Data show that Ago4 (show EIF2C4 Proteins)- Ago1-Ago3 (show EIF2C3 Proteins) genes are linked together at the p12 (show SPRN Proteins) of the chromosome 6, while Ago2 (show EIF2C2 Proteins) is located at the p15 (show CDKN2B Proteins) of the chromosome 4.

Human Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) interaction partners

  1. In miRNA-mediated gene silencing, the physical interaction between human Argonaute (show EIF2C2 Proteins) (hAgo (show FBXW7 Proteins)) and GW182 (hGW182) is essential for facilitating the downstream silencing of the targeted mRNA. hGW182 can recruit up to three copies of hAgo (show FBXW7 Proteins) via its three GW motifs. This may explain the observed cooperativity in miRNA-mediated gene silencing.

  2. We selected five single nucleotide polymorphisms (SNPs) (rs7813, rs2740349, rs2291778, rs910924, rs595961) in two key microRNA biosynthesis genes (GEMIN4 and AGO1) and systematically evaluated the association between these SNPs, the gene-environment interaction and lung cancer risk. This is the first study showing that rs7813 and rs595961 could be meaningful as genetic markers for lung cancer risk.

  3. Low AGO1 expression is associated with melanoma.

  4. Blocking AGO1, AGO2, or TRBP expression changes expression levels and nuclear distribution of RNAi factors Dicer, TNRC6A (GW182), and TRBP.

  5. EIF2C2 (show EIF2C2 Proteins), Dicer (show DICER1 Proteins), and Drosha (show DROSHA Proteins) are more highly expressed in bladder carcinoma, promote the development of bladder cancer, and suggested a poor prognosis

  6. Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing

  7. Completion of the tetrad, combined with a mutation on a loop adjacent to the active site of hAgo1, results in slicer activity that is substantially enhanced by swapping in the N domain of hAgo2 (show EIF2C2 Proteins).

  8. Evolutionary amino acid changes to hAGO1 were readily reversible, suggesting that loading of guide RNA and pairing of seed-based miRNA and target RNA constrain its sequence drift.

  9. nuclear Ago1 directly interacts with RNA Polymerase II and is widely associated with chromosomal loci throughout the genome with preferential enrichment in promoters of transcriptionally active genes

  10. Aberrant expression of argonaute-1/-2 in human renal cell carcinoma (show MOK Proteins) is possibly involved with tumorigenesis and prognosis.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) interaction partners

  1. up-regulated in murine macrophage RAW264.7 cells transfected by Echinococcus multilocularis miR (show MLXIP Proteins)-71

  2. Results from the liver show that, siRNA targets 3'UTR and the coding sequence (CDs (show ABHD5 Proteins)) of endogenous genes in the presence Ago2 (show EIF2C2 Proteins) but in its absence, only 3'UTR-targeted siRNA-mediated knockdown are active with the help of Ago1 and Ago3 (show EIF2C3 Proteins).

  3. enhanced flu susceptibility of Ago1/3 double-knockout mice arises from an intrinsic impairment in the ability of lung cells to tolerate flu-elicited inflammation.

  4. Ago3 (show EIF2C3 Proteins) is able to load microRNAs efficiently in the absence of Ago1 and Ago2 (show EIF2C2 Proteins), despite a significant loss of global microRNA expression

  5. describes cloning rat sequence and used RNA interference to show that the GERp95 (show EIF2C2 Proteins) orthologue in C. elegans is important for maturation of germ-line stem cells in the gonad.

Arabidopsis thaliana Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) interaction partners

  1. Results suggests that ARGONAUTE1 (AGO1) interacts with chromatin at microRNAs MIR161 and MIR173 loci and causes the disassembly of the transcriptional complex, releasing short and unpolyadenylated transcripts.

  2. that AGO1 may have functions in gene regulation independent of small RNAs.

  3. AGO1 is a major, largely HSP90 (show HSP90 Proteins)-independent, factor in providing environmental robustness to plants.

  4. miR168 is a key miRNA because it regulates the expression of the slicer protein ARGONAUTE1 (AGO1), which catalyzes mRNA cleavage. Interestingly, plant miR168s are highly evolutionarily conserved; however, it is unclear whether MIR168 promoter elements and expression patterns are also conserved.

  5. a total of 5,123 and 1,399 AGO1-enriched small RNAs, excluding miRNAs, were identified in Arabidopsis thaliana and rice (Oryza sativa), respectively.

  6. Mungbean yellow mosaic Indian virus AC2 interacts with AGO1 and inhibits its transcript slicing activity in vitro.

  7. AGO1, AGO2 and AGO10 promoted anti-TuMV defense in a modular way in various organs, with AGO2 providing a prominent antiviral role in leaves. AGO5, AGO7 and AGO10 had minor effects in leaves.

  8. HOS1 regulates miR168a/b and AGO1 levels in Arabidopsis by maintaining proper transcription of MIR168b.

  9. Base pairing at the 15th nucleotide of a miRNA duplex is important for miRNA sorting in both Arabidopsis AGO1 and AGO2 (show EIF2C2 Proteins). AGO1 tolerates, or prefers, duplexes with central mismatches.

  10. In the presence of the wild-type allele of AGO1, most of the mas (show MAS1 Proteins) mutations cause a mild or no mutant phenotype on their own, indicating that the ago1-52 mutant may provide a sensitized background for examining the interactions of AGO1.

Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Protein Profile

Protein Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.

Alternative names and synonyms associated with Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1)

  • Argonaute-1 (AGO1)
  • argonaute 1 (AGO1)
  • argonaute 1 (ago1)
  • Argonaute-1 (Ago-1)
  • Argonaute 1 (DsimAGO1)
  • argonaute 1 (Ago1)
  • eukaryotic translation initiation factor 2C, 1 (EIF2C1)
  • argonaute RISC catalytic component 1 (AGO1)
  • argonaute RISC catalytic component 1 (Ago1)
  • argonaute RISC catalytic subunit 1 (Ago1)
  • protein argonaute 1 (AGO1)
  • Ago protein
  • Ago-1 protein
  • ago1 protein
  • ago1-1 protein
  • anon-WO0257455.29 protein
  • ARGONAUTE 1 protein
  • CG6671 protein
  • dAgo1 protein
  • Dm Ago1 protein
  • Dmel\\CG6671 protein
  • DsimGD25729 protein
  • dsim_GLEANR_9718 protein
  • EIF2C protein
  • Eif2c1 protein
  • GB12654 protein
  • GD25729 protein
  • GERP95 protein
  • l(2)04845 protein
  • l(2)4845 protein
  • l(2)k00208 protein
  • l(2)k08121 protein
  • MRE20 protein
  • Q99 protein
  • T1N15.2 protein
  • T1N15_2 protein

Protein level used designations for EIF2C1

AGO1-PA , AGO1-PB , AGO1-PC , AGO1-PD , ARGONAUTE-1 , Argonaute1 , CG6671-PA , CG6671-PB , CG6671-PC , CG6671-PD , argonaute , argonaute 1 , argonaute protein 1 , mRNA-like ncRNA in embryogenesis 20 , Argonaute-1 , DsimAGO1-PA , DsimGD25729-PA , GD25729-PA , argonaute-1 , eukaryotic translation initiation factor 2C, 1 , protein argonaute-1-like , Golgi Endoplasmic Reticulum protein 95 kDa , argonaute1 , eIF-2C 1 , eIF2C 1 , hAgo1 , protein argonaute-1 , putative RNA-binding protein Q99 , Piwi/Argonaute family protein meIF2C1 , argonaute RISC catalytic component 1 , mAgo1

36544 Drosophila melanogaster
552062 Apis mellifera
593855 Strongylocentrotus purpuratus
659936 Tribolium castaneum
6734380 Drosophila simulans
100124421 Bombyx mori
100386910 Callithrix jacchus
100440631 Pongo abelii
100482671 Ailuropoda melanoleuca
100499510 Sus scrofa
456747 Pan troglodytes
26523 Homo sapiens
313594 Rattus norvegicus
236511 Mus musculus
475337 Canis lupus familiaris
841262 Arabidopsis thaliana
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