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Study uncovers a first example of a vertebrate protein factor, Argonaute-3, specifically affecting the guide-to-passenger-strand ratio of the miRNA let-7a. A multi-layered mechanism for the observed impact of Ago3 on the let-7a-3p passenger strand expression and activity is proposed.
The N-terminal domain of Ago3 inhibits cleavage activity. AAs (show FGD1 Proteins) 1-64 are largely unstructured & form a large loop surrounding an area containing two helices & another unstructured loop.
The Ago3 PIWI (show PIWIL1 Proteins) domain is slicing competent but our Ago3 model suggests multiple interactions between residues in the PIWI (show PIWIL1 Proteins) & N domains that may increase protein rigidity or invoke other properties that contribute to Ago3's observed slicing deficiency.
DICER (show DICER1 Proteins)- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation.
Ago3 is able to load microRNAs efficiently in the absence of Ago1 (show EIF2C1 Proteins) and Ago2 (show EIF2C2 Proteins), despite a significant loss of global microRNA expression
reliable predictions of miRNA affinity to Ago2 (show EIF2C2 Proteins) AND Ago3 proteins were made.
The specificity of RNA interference depends on the concentration of Ago1 (show EIF2C1 Proteins), Ago3, and Ago4 (show EIF2C4 Proteins) relative to Ago2 (show EIF2C2 Proteins).
EIF@C3 protein (show RPS3A Proteins) is expressed in both Schwann and neuron-type differentiating cells.
Results from the liver show that, siRNA targets 3'UTR and the coding sequence (CDs (show ABHD5 Proteins)) of endogenous genes in the presence Ago2 (show EIF2C2 Proteins) but in its absence, only 3'UTR-targeted siRNA-mediated knockdown are active with the help of Ago1 (show EIF2C1 Proteins) and Ago3.
enhanced flu susceptibility of Ago1 (show EIF2C1 Proteins)/3 double-knockout mice arises from an intrinsic impairment in the ability of lung cells to tolerate flu-elicited inflammation.
EIF2C2 (show EIF2C2 Proteins)-4 and PIWIL4 (show PIWIL4 Proteins) appear increased in advanced tumors with distant metastasis, suggesting they may promote tumor invasion
Data show that Ago4 (show EIF2C4 Proteins)- Ago1 (show EIF2C1 Proteins)-Ago3 genes are linked together at the p12 (show SPRN Proteins) of the chromosome 6, while Ago2 (show EIF2C2 Proteins) is located at the p15 (show CDKN2B Proteins) of the chromosome 4.
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
, eIF-2C 3
, eIF2C 3
, eukaryotic translation initiation factor 2C, 3
, protein argonaute-3
, argonaute 3b
, argonaute RISC catalytic component 3
, eukaryotic translation initiation factor 2C, 3b
, Piwi/Argonaute family protein meIF2C3
, eukaryotic translation initiation factor 2C 3