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Human FGF18 Protein expressed in Human Cells - ABIN2005560
Reinhold, Naski: Direct interactions of Runx2 and canonical Wnt signaling induce FGF18. in The Journal of biological chemistry 2007
The position of sulfate ions bound to FGF18 provides insight into the putative HS-binding site and allows comparison with the prototypical FGFs, FGF1 (show FGF1 Proteins), and FGF2 (show FGF2 Proteins).
role for FGF-18 in chondrogenic and osteogenic events which drive discal development and ossification of the vertebral bodies.
Fgf18 as a molecule that protects articular cartilage by gene expression profiling, and the anticatabolic effects may at least partially be mediated by the Timp1 (show TIMP1 Proteins) expression.
Tumors from ovarian cancer patients had increased FGF18 expression levels with microvessel density and M2 macrophage infiltration.
FGF8 (show FGF8 Proteins), FGF17 (show FGF17 Proteins), and FGF18 are involved in autocrine and paracrine signaling in HCC (show FAM126A Proteins) and enhance the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis.
There was an association between gene FGF18 rs4043716 and nonsyndromic cleft lip with or without palate in Chinese population.
FGF2 (show FGF2 Proteins) and -18 bind to discrete structures on the heparan sulfate chains attached to chondrocyte-derived perlecan (show HSPG2 Proteins) which modulate the growth factor activities
fibroblast growth factor 18 seems to play a role in maintenance of chondrocyte properties, although its expression was rather high in dedifferentiated chondrocytes.
analysis of FGF18 and FGFR5 (show FGFRL1 Proteins) expression in primary endothelial cells and vascular smooth muscle cells
FGF18 is wildly expressed in the cardiovascular tissue. It enhanced cell migration in response to mechanical damage. we detected FGF18 expression in liver vascular and liver sinusoidal endothelial cells (LSECs), but not in hepatic parenchymal cells.
Loss of alleles of Fgf9 and Fgf18 also affect the expression of genes encoding other key intrinsic skeletal regulators, including IHH, PTHLH (PTHrP), and RUNX2, revealing potential direct, indirect, and compensatory mechanisms to coordinate chondrogenesis and osteogenesis.
retinoic acid is produced by pulmonary endothelial cells and regulates pulmonary angiogenesis and elastin (show ELN Proteins) synthesis by induction of VEGF-A (show VEGFA Proteins) and fibroblast growth factor (FGF)-18, respectively
novel Shh (show SHH Proteins)-Foxf (show FOXF1 Proteins)-Fgf18-Shh (show SHH Proteins) circuit in the palate development molecular network, in which Foxf1 (show FOXF1 Proteins) and Foxf2 (show FOXF2 Proteins) regulate palatal shelf growth downstream of Shh (show SHH Proteins) signaling, at least in part, by repressing Fgf18 expression
post-natal induction of chondrocyte autophagy is mediated by the growth factor FGF18 through FGFR4 (show FGFR4 Proteins) and JNK (show MAPK8 Proteins)-dependent activation of the autophagy initiation complex VPS34 (show PIK3C3 Proteins)-beclin-1 (show BECN1 Proteins)
Phlpp1 deficiency increases Akt2 (show AKT2 Proteins) activity, which diminishes FoxO1 (show FOXO1 Proteins) levels and induces Fgf18 expression to stimulate chondrocyte proliferation.
These results suggest that FGF18 accelerates osteogenesis by upregulation of Bmp2 (show BMP2 Proteins) as well as maintenance or upregulation of Fgfr1 (show FGFR1 Proteins), -2 and -3 expression in osteoblasts.
Fgf-10 (show FGF10 Proteins) and Fgf-18 are expressed specifically within ventral tanycyte subpopulations.
Foxp1 (show FOXP1 Proteins) regulates the quiescent stem cell state in the hair follicle stem cell niche by controlling Fgf18 expression.
These findings therefore argue for an involvement of FGF18 in the control of various developmental events during the alveolar stage.
Fgf-18 is an important mediator of bone regeneration, which is required during later stages of bone regeneration.
FGF18 is proapoptotic in vivo and may act through a mechanism involving the BBC3 (show BBC3 Proteins)-MDM2 (show MDM2 Proteins) pathway.
FGF8 (show FGF8 Proteins) and FGF18 signal through divergent pathways in ovarian granulosa cells, despite reportedly similar receptor activation patterns.
these data point to a unique role for FGF18 in signaling from theca cells to granulosa cells and suggest that FGF18 influences the process of atresia in ovarian follicles.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.
fibroblast growth factor 18