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HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation.
Results identified two proteins P23 (show CDK5R1 Proteins) and HCLS1, which were not known as RNA-binding proteins, exhibiting RNA-binding activity.
Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 (show PAK1 Proteins) and Ezrin (show EZR Proteins) in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 (show FLT3 Proteins) receptors.
studies show that HS1 promotes an early step in the endocytic pathway that is required for efficient Ag presentation of exogenous Ag by dendritic cells
Studies show that HS1 functions in concert with WASp (show WASL Proteins) to fine-tune DC cytoarchitecture and direct cell migration.
In vivo, immunodeficient Rag2 (show RAG2 Proteins)(-/-)gamma(c)(-/-) mice injected with HS1-silenced CLL B cells showed a decreased organ infiltration with the notable exception of the bone marrow.
Hematopoietic lineage cell specific protein 1 (show SP1 Proteins) plays a significant functional role in platelet activation downstream of glycoprotein VI and protease-activated receptors[Hematopoietic lineage cell specific protein 1 (show SP1 Proteins)]
data indicate that Syk (show SYK Proteins) kinase plays an important role in the translocation of hematopoietic lineage cell-specific protein 1 (show SP1 Proteins) (HS1) into lipid rafts
This study concludes that HS1 does not play a major role in platelet function. It is possible that a role for HS1 is masked by the presence of cortactin (show CTTN Proteins).
tyrosine phosphorylation of HS1 occurs downstream of both PAR-1 (show MARK2 Proteins) and PAR-4 (show F2RL3 Proteins). HS1 phosphorylation is a Gq mediated response regulated by Src (show SRC Proteins) kinases
Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins) through PI3 kinase (show PIK3CA Proteins)/Akt (show AKT1 Proteins) protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells.
These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 (show PPARG Proteins) regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.
miR (show MLXIP Proteins)-152 controls both the expression of 14-3-3beta and HLA-G (show HLAG Proteins) and exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity
Data suggest that serum 14-3-3beta concentrations may constitute a useful marker for blood brain barrier damage severity and follow up in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT (show PARP1 Proteins), APAF1 (show APAF1 Proteins), BCL2 (show BCL2 Proteins), BAD, BID (show BID Proteins), MCL1 (show MCL1 Proteins), BIRC4 (show XIAP Proteins), BCL2L1 (show BCL2L1 Proteins), ENDOG (show ENDOG Proteins), YWHAB (show YWHAB Proteins), and YWHAQ (show YWHAQ Proteins), influence promoter activity in an allele-specific manner.
Crystal structure of Myo1c (show MYO1C Proteins)/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin (show INS Proteins)-stimulated glucose uptake.
Data identified three classes of 14-3-3 (show YWHAQ Proteins) targets that all have two binding sites, but displayed synergistic interaction between converging signalling pathways for different ranges of parameter values.
These results indicate that the six YWHAB (show YWHAB Proteins) polymorphisms are not associated with the genetic susceptibility to sporadic Creutzfeldt-Jakob disease.
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
hematopoietic cell-specific Lyn substrate 1
, hematopoietic lineage cell-specific protein
, hematopoietic lineage cell-specific protein-like
, Hematopoietic lineage cell-specific protein
, hematopoietic cell-specific LYN substrate 1
, uncharacterized protein LOC563056
, 14-3-3 alpha
, 14-3-3 protein beta/alpha
, brain protein 14-3-3, beta isoform
, protein 1054
, protein kinase C inhibitor protein 1
, protein kinase C inhibitor protein-1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide