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Browse our ITPR2 Proteins (ITPR2)

Full name:
Inositol 1,4,5-Trisphosphate Receptor, Type 2 Proteins (ITPR2)
On www.antibodies-online.com are 5 Inositol 1,4,5-Trisphosphate Receptor, Type 2 (ITPR2) Proteins from 2 different suppliers available. Additionally we are shipping ITPR2 Antibodies (31) and many more products for this protein. A total of 40 ITPR2 products are currently listed.
Synonyms:
AI649341, InsP3R-2, InsP3R-5, insP3R2, IP3R2, Itpr5
list all proteins Gene Name GeneID UniProt
ITPR2 16439 Q9Z329
ITPR2 81678 P29995
ITPR2 3709 Q14571

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ITPR2 Proteins (ITPR2) by Origin

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Mouse (Murine) Inositol 1,4,5-Trisphosphate Receptor, Type 2 (ITPR2) interaction partners

  1. IP3R2 KO mice had smaller infarction than WT mice in acute and chronic phases of ischemia

  2. Akt2 (show AKT2 Proteins) upregulates dendritic cell migration at least in part by ETS1 (show ETS1 Proteins)-dependent stimulation of IP3R2 transcription.

  3. Disrupting IP3R (show ITPR1 Proteins)/Bcl-2 (show BCL2 Proteins) interaction therefore leads in those cells to increased Ca(2 (show CA2 Proteins)) release and apoptosis. Intriguingly, IP3R2 is not only implicated in apoptosis but also in the induction of senescence, another tumour-suppressive mechanism.

  4. reduced InsP3R (show ITPR1 Proteins)-II expression is not sufficient to account for any disruptions in metabolic homeostasis that are observed in mouse models of obesity

  5. ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin (show PPP3CA Proteins)-NFATc (show NFATC1 Proteins) signaling pathways.

  6. This study demonistrated that hippocampal slices from inositol triphosphate receptor type 2 (IP3R2) knock-out mice which abolished the astrocytic Ca(2 (show CA2 Proteins)+) activity.

  7. IP3R (show ITPR1 Proteins)-deficient acinar cells accumulate zymogen granules, but the mice do not succumb to pancreatic damage or worse pancreatitis outcomes.

  8. Conclude that IP3-R (show ITPR1 Proteins)(2) do not contribute to the progression of dilated cardiomyopathy or pressure overload hypertrophy, despite increased expression and heightened generation of the ligand, Ins (show INS Proteins)(1,4,5)P3.

  9. Results suggest that type 2 IP(3)R (show ITPR1 Proteins) is the major functional IP(3)R (show ITPR1 Proteins) subtype involved in agonist-induced Ca(2 (show CA2 Proteins)+) release in Bergmann glia

  10. serine 150 of the InsP(3)R2 is phosphorylated by CaMKII (show CAMK2G Proteins) and results in a decrease in the channel open probability.

Human Inositol 1,4,5-Trisphosphate Receptor, Type 2 (ITPR2) interaction partners

  1. Studies indicate that the ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1 (show ITPR1 Proteins), IP3R2, IP3R3 (show ITPR3 Proteins)) are the major Ca(2 (show CA2 Proteins)+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).

  2. Data suggest miR (show MLXIP Proteins)-1290 as the new oncomiR involved in laryngeal squamous cell carcinoma pathogenesis probably through downregulation of its target genes MAF (show MAF Proteins) and ITPR2.

  3. results show a functional role of calcium release by the ITPR2 channel and its subsequent accumulation in the mitochondria

  4. High expression of inositol 1,4,5-trisphosphate receptor, type 2 is associated with acute myeloid leukemia (show BCL11A Proteins).

  5. Disrupting IP3R (show ITPR1 Proteins)/Bcl-2 (show BCL2 Proteins) interaction therefore leads in those cells to increased Ca(2 (show CA2 Proteins)) release and apoptosis. Intriguingly, IP3R2 is not only implicated in apoptosis but also in the induction of senescence, another tumour-suppressive mechanism.

  6. A genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese.

  7. Loss of InsP3R2-mediated calcium release causes isolated anhidrosis in humans.

  8. ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin (show PPP3CA Proteins)-NFATc (show NFATC1 Proteins) signaling pathways.

  9. The Galphaq (show GNAQ Proteins)-protein/coupled receptor/IP3R (show ITPR1 Proteins) axis modulates the electromechanical properties of the human myocardium and its propensity to develop arrhythmias.

  10. Studies indicate that three subtypes of inositol 1,4,5-trisphosphate (IP3) receptors (IP3R1 (show ITPR1 Proteins), -2, and -3) are assembled to form homo- and heterotetrameric channels that mediate Ca(2 (show CA2 Proteins)+) release from intracellular stores.

ITPR2 Protein Profile

Protein Summary

receptor for inositol 1,4,5-triphosphate\; involved in regulating intracellular Ca(2+) concentration

Alternative names and synonyms associated with ITPR2

  • inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2)
  • inositol 1,4,5-triphosphate receptor 2 (Itpr2)
  • inositol 1,4,5-trisphosphate receptor, type 2 (Itpr2)
  • AI649341 protein
  • InsP3R-2 protein
  • InsP3R-5 protein
  • insP3R2 protein
  • IP3R2 protein
  • Itpr5 protein

Protein level used designations for ITPR2

inositol 1,4,5-trisphosphate receptor, type 2 , inositol 1,4,5-triphosphate receptor, type 2 , IP3 receptor , IP3R 2 , inositol 1,4,5-triphosphate receptor 5 , inositol 1,4,5-trisphosphate receptor type 2 , inositol 1,4,5-trisphosphate type V receptor , inositol trisphosphate receptor type 2 , type 2 InsP3 receptor , type 2 inositol 1,4,5-trisphosphate receptor , inositol 1,4,5-triphosphate receptor 2 , inositol triphosphate receptor type 2 , insP3R2

GENE ID SPECIES
100599135 Nomascus leucogenys
16439 Mus musculus
81678 Rattus norvegicus
3709 Homo sapiens
486628 Canis lupus familiaris
281878 Bos taurus
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