This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009].
Brown, Mayfield, Volaufova, Argyropoulos: "The gene structure and minimal promoter of the human agouti related protein." in: Gene, Vol. 277, Issue 1-2, pp. 231-8, (2001) (PubMed).
Shutter, Graham, Kinsey, Scully, Lüthy, Stark: "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice." in: Genes & development, Vol. 11, Issue 5, pp. 593-602, (1997) (PubMed).
Ollmann, Wilson, Yang, Kerns, Chen, Gantz, Barsh: "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein." in: Science (New York, N.Y.), Vol. 278, Issue 5335, pp. 135-8, (1997) (PubMed).
Aliases for AGRP Proteins
agouti related neuropeptide (AGRP) Proteins agouti related neuropeptide (Agrp) Proteins agouti-related protein pseudogene (LOC100352591) Proteins AGRT Proteins Agrt Proteins ART Proteins Art Proteins ASIP2 Proteins