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anti-Rat (Rattus) Neuromedin U Antibodies:
anti-Human Neuromedin U Antibodies:
anti-Mouse (Murine) Neuromedin U Antibodies:
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These results reveal an unexpected functional and anatomical interface between the Nmu system and brainstem arousal systems that represents a novel wake-promoting pathway.
Results indicate a mechanism of action for neuromedin U (NmU) in HER2 (show ERBB2 Antibodies)-overexpressing breast cancer that enhances resistance to HER2 (show ERBB2 Antibodies)-targeted drugs through conferring cancer stem cell (CSC) characteristics and expansion of the CSC phenotype.
This study shows an association between a NMU haplotype and anthropometric indices, mainly linked to fat mass, which appears to be age- and sex-specific in children.
Overexpression of Nmu may be involved in the process of regional metastasis of HNSCC, and may serve as a novel and valuable biomarker for predicting regional metastasis in patients with HNSCC.
our results defined NmU as a candidate drug response biomarker for HER2 (show ERBB2 Antibodies)-overexpressing cancers and as a candidate therapeutic target to limit metastatic progression and improve the efficacy of HER-targeted drugs.
a role for NMU gene through interaction with ADRB2 (show ADRB2 Antibodies) gene in bone strength regulation
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.
[review] Taken together with its vascular actions, NMU may be a functional link between energy balance and the cardiovascular system and may provide a future target for therapies directed against the disorders that comprise metabolic syndrome.
These results suggest that NMU plays a role in feeding behavior and catabolic functions via corticotropin-releasing hormone (show CRH Antibodies).
NmU expression is related to Myb (show MYB Antibodies) and that the NmU/NMU1R (show NMUR1 Antibodies) axis constitutes a previously unknown growth-promoting autocrine loop in myeloid leukemia (show BCL11A Antibodies) cells
irreversible binding of NmU to its receptors
These results suggested that NMU can act directly on beta cells through NMUR1 (show NMUR1 Antibodies) in an autocrine or paracrine fashion to suppress insulin (show INS Antibodies) secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin (show INS Antibodies) secretion, and may improve our understanding of glucose homeostasis.
These results suggest that NMU and NMS (show NMS Antibodies) are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS (show NMS Antibodies) might play a more predominant role than NMU.
the anorectic effect of the lipidated NMU is partly mediated by a decrease in gastric emptying which is subject to tachyphylaxis after continuous dosing.
Beta-adrenergic and cholinergic mechanisms are involved in the anxiolytic action of neuromedin-U.
Data show that neuromedin U (NMU)-deficient mice developed less severe arthritis than control mice.
investigation of neuromedin U effects on factors associated with obesity/diabetes: NMU reduced food consumption/body weight; NMU increased body temperature/metabolic rate; NMU improved glucose tolerance; these effects seem to be mediated by NMUR1 (show NMUR1 Antibodies)
Analysis of NMU expression in ob/ob mice revealed elevated NMU mRNA levels in the dorsomedial hypothalamic (DMH (show DST Antibodies)) nucleus of ob/ob mice compared to lean litter-mates. NMU mRNA levels were elevated in the DMH (show DST Antibodies) of mice fasted for 24 h relative to controls
results suggest that endogenous NMU may be involved in reflexes and adaptation to environmental stimuli
NMU plays an important role in the regulation of feeding behavior and energy metabolism independent of the leptin (show LEP Antibodies) signaling pathway.
NMU receptor antagonists could be novel targets for pharmacological inhibition of allergic inflammatory diseases, including asthma.
may induce uterine smooth muscle contraction and selective vasoconstriction
, neuromedin-U receptor 2
, neuromedin U