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NMU2R mRNA expression in the hypothalamus and pituitary changed with the estrus cycle, with the highest level in the proestrus group and the lowest in the estrus group.
Study identified a novel NMUR2 splice variant lacking the third exon and able to form heteromeric complexes with NMUR1 (show NMUR1 Proteins) and NMUR2 without Neuromedin U (NMU (show NMU Proteins)). Its expression can block NMU (show NMU Proteins) signaling suppressing then ovarian cancer cells proliferation.
A cell-based reporter gene assay has been developed and used for the screening of the human NMU2R agonist.
The present data do not support a significant contribution of NMUR2 to the development of hypersensitivity after nerve injury or tissue inflammation
Data show that deficiency of neuromedin receptors NMUR1 (show NMUR1 Proteins) and NMUR2 had no impact on arthritis severity.
The circadian rhythm of neuromedin U (show NMU Proteins) expression in the suprachiasmatic nucleus does not drive a circadian rhythm of corticotrophin-releasing factor (show CRH Proteins) in the paraventricular nucleus.
molecular basis of the NMU2R regulation of food intake and body weight in mice
the pro-nociceptive effects of neuromedin U (show NMU Proteins) in mice appear to be mediated through NMUR2, not NMUR1 (show NMUR1 Proteins)
Long-term central NMU (show NMU Proteins) treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice.
This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight.
neuromedin U receptor type 2
, neuromedin U receptor 2
, neuromedin s receptor 2 protein
, G-protein coupled receptor FM-4
, G-protein coupled receptor TGR-1
, growth hormone secretagogue receptor family, member 4
, neuromedin-U receptor 2
, G-protein-coupled receptor FM-4