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Overexpression of HAS3 decreased ERK1/2 (show MAPK1/3 ELISA Kits) phosphorylation suggesting that inhibition of MAP-kinase (show MAPK1 ELISA Kits) signaling was responsible for decreased melanoma cell adhesion, migration and proliferation.
HAS3 underexpression is associated with advanced tumor stage and adverse pathological features, as well as implies inferior clinical outcomes for both groups of patients with UTUCs and UBUCs, suggesting its critical role in tumor progression
Hyaluronan accumulation by HAS3 favors pancreatic cancer growth.
Transcriptional factor binding analysis indicated that HAS3 gene promoter lacks of canonical TATA box, but contains classical GC box as well as other putative binding sites for transcriptional factors
HAS3 mRNA expression level increases in atopic dermatitis lesions compared with healthy and non-lesional skin
Rab10 (show RAB10 ELISA Kits) silencing increased the plasma membrane residence of HAS3, resulting in a significant increase of hyaluronan secretion and an enlarged cell surface HA coat, whereas Rab10 (show RAB10 ELISA Kits) overexpression suppressed hyaluronan synthesis.
Hyaluronan (HA) produced by HAS3 is a ubiquitous component of the extracellular matrix and plays an active role in tissue remodeling. In addition, HA is known to reduce reactive oxygen species (ROS (show ROS1 ELISA Kits)) -induced cardiac injury.
Data indicate that oxLDL doubled the transcripts of hyaluronan synthases HAS2 (show HAS2 ELISA Kits) and HAS3 and hyaluronan deposition via the scavenger receptor LOX-1 (show OLR1 ELISA Kits).
Inverse expression of hyaluronidase 2 (show HYAL2 ELISA Kits) and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.
Hyaluronan synthase 1 (HAS1 (show HAS1 ELISA Kits)) requires higher cellular UDP-GlcNAc (show B3GNT3 ELISA Kits) concentration than HAS2 (show HAS2 ELISA Kits) and HAS3
HAS3-mediated HA synthesis after vessel injury supports seminal signaling pathways in activation of VSMC, increases platelet-derived growth factor BB-mediated migration, and in turn enhances neointimal hyperplasia in vivo.
This study demonstrates that the ablation of Has3-dependent HA causes reduced ECS volume in the CA1 (show CA1 ELISA Kits) stratum pyramidale, epileptiform activity in the CA1 (show CA1 ELISA Kits) region, and epileptic seizures in the mutant mouse.
Selective loss of Has1 (show HAS1 ELISA Kits) and Has3 leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.
sequence of xlHAS3(hyaluronan synthase 3) mRNA, its genomic organization and expression in adult tissues as well as during embryonic development; in situ hybridization indicates that expression is restricted to the developing inner ear and cement gland
hyaluronan synthase 3 is expressed by the porcine endosalpinx epithelium and the levels of expression do not vary during the critical periods of sperm transport and fertilization
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants.
hyaluronan synthase 3
, hyaluronan synthase 3-like
, HA synthase 3
, hyaluronate synthase 3
, hyaluronic acid synthase 3