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Human SLC9A1 ELISA Kit for Sandwich ELISA - ABIN420041
Park, Oh, Kim, Park: Acceleration of Collagen Breakdown by Extracellular Basic pH in Human Dermal Fibroblasts. in Skin pharmacology and physiology 2016
Co-overexpression of AtNHX1 and SOS1 (show SOS1 ELISA Kits) could significantly reduce yield loss caused by the combined stresses of heat and salt, confirming the hypothesis that stacked overexpression of two genes could substantially improve tolerance against multiple stresses.
Tonoplast-localized NHX1 and NHX2 proteins are essential for active K+ uptake at the tonoplast, for turgor regulation, and for stomatal function.
Overexpression of AtNHX1 gene not only improved salt tolerance but also drought tolerance in transgenic groundnut.
NHX1 and NHX2 mediate K+/H+ exchange to accumulate K+ in the vacuole. NHX1 and NHX2 function together to control cell expansion in vegetative tissues and male reproductive organs and are required for normal flower development.
Studies shoe that the rutin content of the roots, stems and leaves of AtNHX1 transgenic buckwheat increased than those of the control plants.
Use of the T-DNA insertional mutant of AtNHX1 (nhx1 plants) and DNA arrays to assess differences in transcriptional profiles and further characterize the roles of this protein.
the presence of a vacuolar calmodulin-like (show KRIT1 ELISA Kits) protein acting on the vacuolar-localized AtNHX1 C terminus in a Ca(2 (show CA2 ELISA Kits)+)- pH-dependent manner suggests the presence of signaling entities acting within the vacuole.
AtNHX1 has a role in calcium signaling, sulfur metabolism, cell structure and cell growth, as well as vesicular trafficking and protein processing.
To generate salt-tolerant turf and forage, tall fescue (Festuca arundinacea) was transformed with AtNHX1.
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 (show JAK2 ELISA Kits) first becomes prominent during mouse embryonic development at the late one-cell stage.
Lack of Dicer (show DICER1 ELISA Kits) leads to oxidative stress, cytosolic acidification, upregulated NHE1 expression and activity as well as swelling of CD4 (show CD4 ELISA Kits)+ T cells, functions all reversed by miR (show MLXIP ELISA Kits)-15b or miR (show MLXIP ELISA Kits)-200b.
DJ-1 (show PARK7 ELISA Kits) is a powerful regulator of reactive oxygen species production as well as NHE1 expression and activity in CD4 (show CD4 ELISA Kits)(+) T cells.
Overexpressed NHE1 suppresses the expression of ABCA1 protein via increasing the calpain activity in RAW264.7 cells.
Inhibition of NHE1 by siRNA-NHE1 or with cariporide in CD4 (show CD4 ELISA Kits)(+) T helper 9 (Th9) cells down-regulated IL-9 (show IL9 ELISA Kits) and ATP production.
The current study concluded that NHE1 activity and pHi homeostasis are regulated by CoCl2 treatment in a time-dependent manner in astrocytes, and may be responsible for the changes in cell viability and injury observed under hypoxia-mimetic conditions induced by CoCl2 treatment.
During hypoxia, activation of ROCK enhances NHE1 activity and promotes pulmonary artery smooth muscle cell migration and proliferation.
Na/H exchanger is regulated in dendritic cells by Akt1 (show AKT1 ELISA Kits).
our results suggest that activation of NHE1 induces hypertrophy through the activation of NFAT3 (show NFATC4 ELISA Kits)/Gata4 (show GATA4 ELISA Kits) and OPN (show SPP1 ELISA Kits) expression
NHE1 function is necessary for maintaining mammary branched architecture.
This study evaluated the role for NHE-1 in diabetic cataract formation and retinal oxidative stress and apoptosis.
Results support the hypothesis that a blood-brain barrier Na/H exchanger, possibly NHE1 and/or NHE2 (show SLC9A2 ELISA Kits), is stimulated during ischemia to participate in cerebral edema formation.
NHE isoform switching and KChIP2 (show KCNIP2 ELISA Kits) upregulation takes place in aging porcine atria.
NHE-1 inhibitor cariporide attenuates skeletal muscle infarction when administered before ischemia or reperfusion.
Data show for the first time that PRLR (show PRLR ELISA Kits) activation stimulates breast cancer cell invasiveness via the activation of NHE1. Data propose that PRL (show PRL ELISA Kits)-induced NHE1 activation and the resulting NHE1-dependent invasiveness may contribute to the metastatic behavior of human breast cancer cells.
These data provides the first insight into the signalling molecules that form the NHE1 interactome in triple-negative breast cancer cells.
NHE1 is a plasma membrane transporter that uses the energy of the chemical gradient created by the Na+/K+ ATPase (show ATP1A1 ELISA Kits) to couple the transport of one extracellular sodium for one intracellular proton. NHE1 functional domains, functional features, protein interactions, role in cell migration, and inhibitors are reviewed. A model of its role in pH control in tumor cells is described. Review.
The transcription factor Zeb1 (show ZEB1 ELISA Kits) binds to the Na+/H+ exchanger 1 promoter, suggesting that Zeb1 (show ZEB1 ELISA Kits) directly controls Na+/H+ transcription.
NHE1 function plays an important role in glioma-microglia interactions, enhancing glioma proliferation and invasion by stimulating microglial release of soluble factors.
results demonstrate that early stop codon polymorphisms have significant and deleterious effects on the activity of the SLC9A1 protein product. The 735-NHE1 mutant, without the last 80 amino acids, had more minor defects
the accumulation of reactive oxygen species (ROS (show ROS1 ELISA Kits)) in cells expressing JAK2V617F compromises the NHE-1/Bcl-xL (show BCL2L1 ELISA Kits) deamidation pathway by repressing NHE-1 upregulation in response to DNA damage. hematopoietic stem cells (HSCs), FOXO3A (show FOXO3 ELISA Kits) is largely localized within the nuclei despite the presence of JAK2V617F mutation, suggesting that JAK2 (show JAK2 ELISA Kits)-FOXO (show FOXO3 ELISA Kits) signaling has a different effect on progenitors compared with stem cells.
Findings suggest that Na(+)/H(+) exchanger1 (NHE1) could be a target for anti-invasion/metastasis therapy.
These data identify a molecular mechanism for pH-sensitive PI(4,5)P2 binding regulating NHE1 activity and suggest that the evolutionarily conserved cluster of four histidines in the proximal cytoplasmic domain of NHE1 may constitute a proton modifier site.
Results indicate that Nav 1.7 promotes GC progression through MACC1 (show MACC1 ELISA Kits)-mediated upregulation of NHE1.
In vitro phosphorylation of NHE1 C-terminal fusion proteins determined that ERK (show MAPK1 ELISA Kits)-dependent phosphorylation of the cytoplasmic region was not dependent on Ser (show SIGLEC1 ELISA Kits)(703); however, phosphorylation by p90(rsk (show RPS6KA1 ELISA Kits)) required Ser (show SIGLEC1 ELISA Kits)(703).
This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth.
, Na(+)/H(+) exchanger 1
, Na+/H+ antiporter
, Na+/H+, amiloride sensitive
, slow-wave epilepsy
, sodium/hydrogen exchanger 1
, solute carrier family 9 member 1
, solute carrier family 9, member 1
, sodium proton exchanger
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)
, solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)
, Solute carrier family 9 member 1
, NA(+)-H+ exchanger protein
, Na-Li countertransporter
, Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)
, solute carrier family 9 (sodium/hydrogen exchanger), member 1
, Na+/H+ exchanger
, pH regulatory protein (Na(+) /H(+) exchanger)