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Dzip1-dependent stabilization of Spop (show SPOP Proteins)/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Proteins)/Ci proteins in the Hh pathway.
reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 (show CSNK2B Proteins) and B56-containing PP2As, has an important impact on the stability of Gli (show GLI1 Proteins) transcription factors and Hh signaling.
centrosome protein Dzip1 mediates the assembly of the BBSome-Dzip1-PCM1 complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome. Phosphorylation of Dzip1 at Ser-210 by Plk1 (polo-like kinase 1) during the G2 phase promotes disassembly of this complex, resulting in removal of Dzip1 and the BBSome from the CS.
demonstrated that Dzip1 was phosphorylated by GSK3beta at S520 in G0 phase, which increased its binding to GDI2 (show GDI2 Proteins) to promote the release of Rab8GDP at the cilium base
Data indicate that the centrosomal protein DZIP1 interacts with GLI3 (show GLI3 Proteins) transcription factor in the cytoplasm and regulates Hedgehog (show SHH Proteins) signaling and ciliogenesis.
reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 (show CSNK2A1 Proteins) and B56-containing PP2As, has an important impact on the stability of Gli (show GLI1 Proteins) transcription factors and Hh signaling.
The abundance of DZIP1-associated mRNAs increased with treatment.
gene expression profiling [DZIP]
Comparative analysis of genes regulated by Dzip1/iguana and hedgehog (show SHH Proteins) in zebrafish.
Igu/Dzip1 functions as a permissive factor that is required for the proper regulation of Hh target genes in response to Hh signals.
zebrafish iguana gene product acts in the somites of the developing embryo and can shuttle between the cytoplasm and nucleus in a manner correlated with Hedgehog (show SHH Proteins) pathway activity.
Results indicate that a critical and broadly conserved function for Iguana is in ciliogenesis and that this function has come to be required for Hedgehog (show SHH Proteins) signaling in vertebrates
Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo.
DAZ interacting protein 1
, DAZ-interacting protein 1 homolog
, zinc finger protein DZIP1
, DAZ interacting protein testis1
, DAZ-interacting protein 1/2
, zinc finger DAZ interacting protein 1
, zinc-finger protein DZIPt1
, iguana protein
, zin finger protein igu/dzip1
, zinc finger protein Dzip1