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The serum levels of IHH and SHH (show SHH Proteins) were significantly higher in autistic subjects than those of control subjects. The findings support a correlation between SHH (show SHH Proteins), IHH and BDNF (show BDNF Proteins) in autistic children, suggesting their pathological role in autism.
Our results show for the first time that Indian hedgehog does not cause extracellular matrix degradation in healthy ex vivo cartilage or in the presence of IL-1beta (show IL1B Proteins)
The Annexin a2 (show ANXA2 Proteins) Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog (show SHH Proteins) Pathway.
Studies indicate that the hedgehog (show SHH Proteins) (Hh) signaling pathway has become one of the most studied potential therapeutic targets in hematological malignancies.
Findings demonstrated that Ihh promotes human cartilage endplate degeneration.
endogenously produced IHH is playing a critical role in regulating hBMSC chondrogenesis.
Duplication of the upstream IHH regulatory region and a correlation between the phenotype and the implicated regulatory regions in a family with craniosynostosis Philadelphia type.
Data show that the Hh (Hedgehog (show SHH Proteins)) signalling pathway mediates chemoresistance of BCSCs (breast cancer stem cells) and contributes to the outcome in breast cancer patients.
Data suggest that hedgehog (HH) signaling through transcription factors GLI1 and GLI2 could be required for the maintenance of pregnancy.
Studies indicate that activation of the hedgehog (show SHH Proteins) (Hh) signaling pathway has been observed in several cancer types, including ovarian cancer.
findings thus demonstrate that augmented Ihh signaling is detrimental to craniofacial development, and that finely tuned Ihh signaling is critical for temporomandibular joint formation.
Ihh has an important role in regulating limb mesenchymal cell differentiation
Ihh and PTH1R (show PTH1R Proteins) signaling in limb mesenchyme are both essential to regulate proper development of digit structures, although they appear to use different mechanisms.
Ihh expression was downregulated in femur epiphyses of Hand1 (show HAND1 Proteins)-overexpressing mice. Hand1 (show HAND1 Proteins) downregulated Ihh gene expression in vitro by inhibiting Runx2 (show RUNX2 Proteins) transactivation of the Ihh proximal promoter.
In organogenesis of the ovary, production of Dhh (show DHH Proteins)/Ihh in granulosa cells requires growth differentiation factor 9 (show GDF9 Proteins) from the oocyte.
C/EBPbeta (show CEBPB Proteins) and RUNX2 (show RUNX2 Proteins) cooperatively stimulate expression of Ihh through direct interactions with a C/EBPbeta (show CEBPB Proteins) binding element, which further promotes hypertrophic differentiation of chondrocytes during the chondrocyte differentiation process.
findings support the protective role of Ihh deletion in surgically induced osteoarthritis
Thyroid hormone (show PTH Proteins) regulates the secondary ossification center initiation and progression via differentiating chondrocytes into bone matrix-producing osteoblasts by stimulating Ihh and Osx (show SP7 Proteins) expression in chondrocytes.
Apc (show APC Proteins) mutant epithelial cells secrete IHH to maintain an intestinal stromal phenotype that is required for adenoma development in mice.
By a combination of embryological andmolecular approaches the results demonstrated that Indian hedgehog protein signaling drives the migration of neural crest cells by autocrine or paracrine mechanisms.
Considered collectively, the present study suggests that X-bhh evolutionally acquired the function to induce osteogenesis; however, the expression profile of X-bhh in epiphysis is related to the late development of endochondral ossification in X. laevis.
Data indicate that SRY-box containing gene 4 protein (Sox4) is required to limit the extent of Hedgehog (show SHH Proteins) (Hh) signaling during eye development.
Cxcr4a is required for Hh-dependent cell proliferation but not for Hh-dependent patterning
Data showe that hedgehog (Hh) signaling regulates the expression of pth2 transcripts.
This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.
Indian hedgehog homolog
, Indian hedgehog
, indian hedgehog protein-like
, indian hedgehog protein
, banded hedgehog protein
, indian hedgehog homolog
, echidna hedgehog protein
, indian hedgehog B protein