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Browse our Indian Hedgehog Proteins (IHH)

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Indian Hedgehog Proteins (IHH)
On are 23 Indian Hedgehog (IHH) Proteins from 6 different suppliers available. Additionally we are shipping Indian Hedgehog Antibodies (131) and Indian Hedgehog Kits (28) and many more products for this protein. A total of 187 Indian Hedgehog products are currently listed.
BDA1, bhh, bhh-a, ehh, HHG2, IHH, X-hh, Xbhh, zgc:113262
list all proteins Gene Name GeneID UniProt
IHH 3549 Q14623
IHH 16147 P97812
Rat IHH IHH 84399  

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Indian Hedgehog Proteins (IHH) by Origin

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Human Indian Hedgehog (IHH) interaction partners

  1. Our results show for the first time that Indian hedgehog does not cause extracellular matrix degradation in healthy ex vivo cartilage or in the presence of IL-1beta (show IL1B Proteins)

  2. The Annexin a2 (show ANXA2 Proteins) Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog (show SHH Proteins) Pathway.

  3. Studies indicate that the hedgehog (show SHH Proteins) (Hh) signaling pathway has become one of the most studied potential therapeutic targets in hematological malignancies.

  4. Findings demonstrated that Ihh promotes human cartilage endplate degeneration.

  5. endogenously produced IHH is playing a critical role in regulating hBMSC chondrogenesis.

  6. Duplication of the upstream IHH regulatory region and a correlation between the phenotype and the implicated regulatory regions in a family with craniosynostosis Philadelphia type.

  7. Data show that the Hh (Hedgehog (show SHH Proteins)) signalling pathway mediates chemoresistance of BCSCs (breast cancer stem cells) and contributes to the outcome in breast cancer patients.

  8. Data suggest that hedgehog (HH) signaling through transcription factors GLI1 and GLI2 could be required for the maintenance of pregnancy.

  9. Studies indicate that activation of the hedgehog (show SHH Proteins) (Hh) signaling pathway has been observed in several cancer types, including ovarian cancer.

  10. Gene transfer of indian hedgehog protein results in chondrogenic induction of mesenchymal stem cells.

Mouse (Murine) Indian Hedgehog (IHH) interaction partners

  1. The Annexin a2 (show ANXA2 Proteins) Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog (show SHH Proteins) Pathway.

  2. Ihh expression was downregulated in femur epiphyses of Hand1 (show HAND1 Proteins)-overexpressing mice. Hand1 (show HAND1 Proteins) downregulated Ihh gene expression in vitro by inhibiting Runx2 (show RUNX2 Proteins) transactivation of the Ihh proximal promoter.

  3. In organogenesis of the ovary, production of Dhh (show DHH Proteins)/Ihh in granulosa cells requires growth differentiation factor 9 (show GDF9 Proteins) from the oocyte.

  4. C/EBPbeta (show CEBPB Proteins) and RUNX2 (show RUNX2 Proteins) cooperatively stimulate expression of Ihh through direct interactions with a C/EBPbeta (show CEBPB Proteins) binding element, which further promotes hypertrophic differentiation of chondrocytes during the chondrocyte differentiation process.

  5. findings support the protective role of Ihh deletion in surgically induced osteoarthritis

  6. Thyroid hormone (show PTH Proteins) regulates the secondary ossification center initiation and progression via differentiating chondrocytes into bone matrix-producing osteoblasts by stimulating Ihh and Osx (show SP7 Proteins) expression in chondrocytes.

  7. Apc (show APC Proteins) mutant epithelial cells secrete IHH to maintain an intestinal stromal phenotype that is required for adenoma development in mice.

  8. Cbfbeta (show CBFB Proteins) functions in upregulating Ihh expression to promoter chondrocyte proliferation and osteoblast differentiation, and inhibiting PPR (show PTH1R Proteins) expression to enhance chondrocyte differentiation.

  9. Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease.

  10. Data indicate Indian hedgehog (Ihh) induces collagen type X COL10A1 (show COL10A1 Proteins) expression and promotes its transcription through Runx2 (show RUNX2 Proteins)/Smad1 (show SMAD1 Proteins) interactions on a specific promoter region.

Xenopus laevis Indian Hedgehog (IHH) interaction partners

  1. By a combination of embryological andmolecular approaches the results demonstrated that Indian hedgehog protein signaling drives the migration of neural crest cells by autocrine or paracrine mechanisms.

  2. Considered collectively, the present study suggests that X-bhh evolutionally acquired the function to induce osteogenesis; however, the expression profile of X-bhh in epiphysis is related to the late development of endochondral ossification in X. laevis.

Zebrafish Indian Hedgehog (IHH) interaction partners

  1. Data indicate that SRY-box containing gene 4 protein (Sox4) is required to limit the extent of Hedgehog (show SHH Proteins) (Hh) signaling during eye development.

  2. Cxcr4a is required for Hh-dependent cell proliferation but not for Hh-dependent patterning

  3. Data showe that hedgehog (Hh) signaling regulates the expression of pth2 transcripts.

Indian Hedgehog (IHH) Protein Profile

Protein Summary

This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.

Alternative names and synonyms associated with Indian Hedgehog (IHH)

  • Indian hedgehog (IHH)
  • indian hedgehog (IHH)
  • Indian hedgehog (Ihh)
  • indian hedgehog (ihh)
  • Indian hedgehog homolog b (ihhb)
  • BDA1 protein
  • bhh protein
  • bhh-a protein
  • ehh protein
  • HHG2 protein
  • IHH protein
  • X-hh protein
  • Xbhh protein
  • zgc:113262 protein

Protein level used designations for Indian Hedgehog Proteins (IHH)

Indian hedgehog homolog , Indian hedgehog , indian hedgehog protein-like , HHG-2 , indian hedgehog protein , X-BHH , banded hedgehog protein , indian hedgehog homolog , echidna hedgehog protein , hh[b] , hhb , indian hedgehog B protein

100033984 Equus caballus
100466890 Ailuropoda melanoleuca
100580536 Nomascus leucogenys
3549 Homo sapiens
16147 Mus musculus
378540 Xenopus laevis
395801 Gallus gallus
84399 Rattus norvegicus
488533 Canis lupus familiaris
397174 Sus scrofa
30299 Danio rerio
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