Browse our IFIT1 Proteins (IFIT1)

Full name:
Interferon-Induced Protein with Tetratricopeptide Repeats 1 Proteins (IFIT1)
On www.antibodies-online.com are 6 Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) Proteins from 4 different suppliers available. Additionally we are shipping IFIT1 Antibodies (40) and IFIT1 Kits (8) and many more products for this protein. A total of 63 IFIT1 products are currently listed.
Synonyms:
C56, DKFZp469C2331, G10P1, Garg16, IFI-56, IFI-56K, Ifi56, IFIT-1, Ifit1, IFNAI1, ISG56, P56, RNM561
list all proteins Gene Name GeneID UniProt
Rat IFIT1 IFIT1 294090  
IFIT1 3434 P09914
IFIT1 15957 Q64282

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IFIT1 Proteins (IFIT1) by Origin

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Human Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) interaction partners

  1. Taken together, this study revealed that IFIT1 played an important antiviral role in human cytomegalovirus infected fetal astrocytes.

  2. Glioblastoma patients with high IFIT1 and low MGMT (show MGMT Proteins) expression have an improved prognosis.

  3. IFIT1 significantly inhibited human parainfluenza virus type 3, whereas IFIT2, IFIT3, and IFIT5 were less effective or not at all.

  4. All the rubulaviruses tested were sensitive to the antiviral action of ISG56/IFIT1.

  5. IFIT1 is involved in the regulation of IFNalpha treatment for chronic hepatitis B and its polymorphism rs303218 can predict the end point virological response.

  6. there is a positive feedback loop between phosphorylated STAT1 and ISG56, ISG54 or ISG60.

  7. Data show that interferon (show IFNA Proteins)-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 and IFIT2 (show IFIT2 Proteins)) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps.

  8. IFIT1 is not a dominant restriction factor against three different families of negative-sense RNA viruses.

  9. Reovirus T3D infection induced STAT-1, ISG-15, IFIT-1, Mx1, and IFIT-3 expression.

  10. The specificity of IFIT1 for 2'O-unmethylated RNA serves as potent antiviral mechanism against viruses lacking 2'O-methyltransferase activity and at the same time allows unperturbed progression of the antiviral program in infected cells.

Mouse (Murine) Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) interaction partners

  1. the mechanism for the observed differential induction of the mouse Ifit1, Ifit2 (show IFIT2 Proteins), and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8 (show IRF8 Proteins)), which is highly expressed in B cells, played an essential role in this regulation.

  2. Data suggest that, with up-regulation of IFIT1, alphaviruses (Venezuelan equine encephalitis virus; Chikungunya virus) with wild-type 5' untranslated regions are inducers of type I IFN (interferon (show IFNA Proteins)), suggesting a new mechanism of type I IFN induction.

  3. Targeted expression of Ifit1 in hepatocytes protects mice from lipopolysaccharide and D-galactosamine induced lethal hepatitis.

  4. IFIT1 is not a dominant restriction factor against three different families of negative-sense RNA viruses.

  5. The specificity of IFIT1 for 2'O-unmethylated RNA serves as potent antiviral mechanism against viruses lacking 2'O-methyltransferase activity and at the same time allows unperturbed progression of the antiviral program in infected cells.

  6. Thus, Ifit1 inhibits replication of MTase (show DNMT1 Proteins)-defective Japanese encephalitis virus by inhibiting mRNA translation through direct binding to mRNA 5' structures.

  7. Study identified Ifit1 as an important innate immune bottleneck.

  8. results suggest that virulent strains of West Nile virus have largely evaded the antiviral effects of Ifit1, and viral mutants lacking 2'-O methylation are controlled in vivo by Ifit1-dependent and -independent mechanisms in different cell types

  9. IFIT1 bound PPP-RNA antagonizes viruses by sequestering specific viral nucleic acids.

  10. Under some stressful stimulations IFIT1 may participate in cell death pathways by interaction with eEF1A (show EEF1A2 Proteins).

IFIT1 Protein Profile

Protein Summary

This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

Alternative names and synonyms associated with IFIT1

  • interferon-induced protein with tetratricopeptide repeats 1-like B (Ifit1lb)
  • interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)
  • interferon-induced protein with tetratricopeptide repeats 1 (ifit1)
  • interferon-induced protein with tetratricopeptide repeats 1 (Ifit1)
  • C56 protein
  • DKFZp469C2331 protein
  • G10P1 protein
  • Garg16 protein
  • IFI-56 protein
  • IFI-56K protein
  • Ifi56 protein
  • IFIT-1 protein
  • Ifit1 protein
  • IFNAI1 protein
  • ISG56 protein
  • P56 protein
  • RNM561 protein

Protein level used designations for IFIT1

interferon-induced protein with tetratricopeptide repeats 1 , interferon-induced protein with tetratricopeptide repeats 5-like , interferon-induced protein with tetratricopeptide repeats 1-like , interferon, alpha-inducible protein (MW 56kD) , interferon-induced 56 kDa protein , interferon-inducible mRNA 561 , GARG-16 , IFI-56K , IFIT-1 , glucocorticoid-attenuated response gene 16 protein , glucocorticoid-attenuated response gene 16 product , interferon-induced protein with tetratricopeptide repeats 1-like protein

GENE ID SPECIES
294090 Rattus norvegicus
450587 Pan troglodytes
488947 Canis lupus familiaris
495383 Xenopus laevis
695683 Macaca mulatta
100058990 Equus caballus
100139670 Bos taurus
100173806 Pongo abelii
100216071 Xenopus (Silurana) tropicalis
100406756 Callithrix jacchus
100475782 Ailuropoda melanoleuca
100585530 Nomascus leucogenys
3434 Homo sapiens
15957 Mus musculus
56824 Rattus norvegicus
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