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None of the eleven AGPAT6 variants were robustly associated with type 2 diabetes in the Danish.
Results reveal a link between the lipogenic effects of insulin (show INS Proteins) and microsomal GPAT3 and GPAT4, implying their importance in glycerolipid biosynthesis.
AGPAT6 is a microsomal GPAT (show PPAT Proteins), and we propose renaming this enzyme GPAT4.
Variants affecting the expression of AGPAT6 are causally involved in differential milk fat synthesis, with pleiotropic consequences for a diverse range of other milk components.
The results of this study suggest that suggest that SLC27A6, ACSL1 (show Acsl1 Proteins), FABP3 (show FABP3 Proteins), AGPAT6, and LPIN1 (show LPIN1 Proteins) coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.
These data identify SEIPIN as an evolutionarily conserved regulator of microsomal GPAT.
GPAT4 limits excessive fatty acid oxidation and the detrimental induction of a hypermetabolic state
Data (from studies in knockout mice) suggest GPAT4-derived phosphatidic acid impairs insulin (show INS Proteins) signaling in liver/contributes to insulin (show INS Proteins) resistance via interaction of mTOR (mechanistic target of rapamycin (show FRAP1 Proteins))/Rictor (RPTOR (show RPTOR Proteins) independent companion of mTOR (show FRAP1 Proteins)).
GPAT1 (show GPAM Proteins), but not GPAT4, is required to incorporate de novo synthesized fatty acids into TAG and to divert them away from oxidation.
Glycerol-3-phosphate acyltransferase 4 might play an important role in spermatogenesis, especially in mid-meiosis.[Glycerol-3-phosphate acyltransferase 4]
Expression in testis increased steadily with spermatogenesis & sexual maturation. It may play an important role in spermatogenesis & development of cryptorchid testes, & is testis-specific (show AIF1 Proteins) apoptosis candidate oncogene (show RAB1A Proteins)
Results show that Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family.
Results identify a novel glycerolipid acyltransferase of the endoplasmic reticulum, AGPAT6, which is crucial for the production of milk fat by the mammary gland.
"Agpat6(-/-) mice" are actually deficient in a novel NEM-sensitive sn-Glycerol-3-phosphate acyltransferase (GPAT), GPAT4
AGPAT6 is a microsomal GPAT (show GPAM Proteins), and we propose renaming this enzyme GPAT4.
GPAT6 is important for tapetum development and plays multiple roles in plant fertility.
Lysophosphatidic acid acyltransferases (EC 184.108.40.206) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.
putative lysophosphatidic acid acyltransferase
, 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
, 1-AGP acyltransferase 6
, 1-acyl-sn-glycerol-3-phosphate acyltransferase zeta
, glycerol-3-phosphate acyltransferase 6
, lysophosphatidic acid acyltransferase zeta
, testis spermatogenesis apoptosis-related protein 7
, glycerol-3-phosphate acyltransferase 4
, 1-AGPAT 6
, acyl-CoA:glycerol-3-phosphate acyltransferase 4