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Browse our PERK Proteins (EIF2AK3)

Full name:
Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 Proteins (EIF2AK3)
On www.antibodies-online.com are 11 Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) Proteins from 6 different suppliers available. Additionally we are shipping PERK Antibodies (172) and PERK Kits (20) and many more products for this protein. A total of 211 PERK products are currently listed.
Synonyms:
AI427929, EIF2AK3, PEK, PERK, WRS
list all proteins Gene Name GeneID UniProt
EIF2AK3 13666  
EIF2AK3 29702 Q9Z1Z1
EIF2AK3 9451 Q9NZJ5

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PERK Proteins (EIF2AK3) by Origin

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More Proteins for PERK Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. Findings indicate that PERK kinase-activating transcription factor 4 (ATF4 (show ATF4 Proteins)) pathway affected the efficiency of X-box binding protein 1 (XBP1 (show XBP1 Proteins)) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha (show ERN1 Proteins)) expression.

  2. This study demonstrated that Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.

  3. Data show that EIF2AK3/PERK-mediated downregulation of miR (show MLXIP Proteins)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 Proteins) protein and activating transcription factor 6 (ATF6 (show ATF6 Proteins)) during conditions of endoplasmic reticulum stress.

  4. Inhibition of eIF2alpha phosphorylation via PERK suppression and reversal of de novo protein synthesis deficits can mitigate cognitive deficits in neurodegenerative diseases.

  5. PlGF (show PGF Proteins) inhibition attenuates PERK activation, likely by tempering hypoxia in HCC (show FAM126A Proteins) via vessel normalisation. The UPR is able to regulate PlGF (show PGF Proteins) expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR

  6. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK and a downstream effector of its activation, CHOP (show DDIT3 Proteins), in tubule cell production of fibronectin (show FN1 Proteins)

  7. Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.

  8. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  9. Results show that PERK-eIF2alpha (show EIF2A Proteins)-mediated translational failure is a key process leading to neuronal loss in a mouse model of frontotemporal dementia, where the misfolded protein is a form of mutant tau

  10. whole-body or pancreas-specific Perk ablation in mice leads to an increase in IFNAR1 (show IFNAR1 Proteins) protein levels and signaling in pancreatic tissues.

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. BiP/GRP78 (show HSPA5 Proteins) and PERK were highly expressed.

  2. plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 Proteins)), protein kinase (show CDK7 Proteins) R (PKR (show PKLR Proteins))like ER kinase (PERK), and inositolrequiring enzyme 1 (IRE1 (show ERN1 Proteins)). Elevated expression of spliced Xbox binding protein 1 (XBP1 (show XBP1 Proteins)) and CCAAT/enhancerbinding protein homologous protein (CHOP (show DDIT3 Proteins)) further confirmed that ROS (show ROS1 Proteins) generatedby NTGP induces apoptosis through the ER stress

  3. PERK-eIF2alpha (show EIF2A Proteins)-ATF4 (show ATF4 Proteins) signaling pathway mediated by endoplasmic reticulum stress involved in osteoblast differentiation of periodontal ligament cells under cyclic mechanical force.

  4. EnR (show LARGE Proteins) stress assessed by expression of PERK and p-eIF2alpha (show EIF2A Proteins) was significantly associated with tumor infiltrating lymphocytes in HER2 (show ERBB2 Proteins)-positive breast cancer.

  5. Influenza A virus downregulates the host unfolded protein response mediated by the PERK protein.

  6. Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism

  7. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Proteins) formation upstream of AMP-activated protein kinase (show PRKAA2 Proteins) and protein kinase (show CDK7 Proteins) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 Proteins) pathways and p21 Cip1 (show CDKN1A Proteins) expression.

  8. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  9. Data from 2 consanguineous families suggest EIF2AK3 mutations (c.1337_1338insT/p.K346*; c.3009C>T/p.R903*) account for Wolcott-Rallison syndrome; ultrastructural features of autopsy materials suggest endoplasmic reticulum dysfunction. [CASE STUDIES]

  10. CGK733-induced intracellular calcium sequestration in pancreatic tumor cells is correlated with the PERK/CHOP (show DDIT3 Proteins) signaling pathway and may also be involved in the dysregulations of calcium-binding proteins.

PERK (EIF2AK3) Protein Profile

Protein Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Alternative names and synonyms associated with PERK (EIF2AK3)

  • eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
  • eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3)
  • AI427929 protein
  • EIF2AK3 protein
  • PEK protein
  • PERK protein
  • WRS protein

Protein level used designations for EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3 , eukaryotic translation initiation factor 2-alpha kinase 3-like , PRKR-like endoplasmic reticulum kinase , pancreatic eIF2-alpha kinase , eukaryotic translation initiation factor 2 alpha kinase 3 , hsPEK , pancreatic EIF2-alpha kinase

GENE ID SPECIES
459388 Pan troglodytes
475756 Canis lupus familiaris
699575 Macaca mulatta
100029557 Monodelphis domestica
100066488 Equus caballus
100394186 Callithrix jacchus
100447385 Pongo abelii
100479743 Ailuropoda melanoleuca
13666 Mus musculus
29702 Rattus norvegicus
9451 Homo sapiens
535820 Bos taurus
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