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Browse our PERK Proteins (EIF2AK3)

Full name:
Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 Proteins (EIF2AK3)
On www.antibodies-online.com are 12 Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) Proteins from 7 different suppliers available. Additionally we are shipping PERK Antibodies (166) and PERK Kits (20) and many more products for this protein. A total of 206 PERK products are currently listed.
Synonyms:
AI427929, EIF2AK3, PEK, PERK, WRS
list all proteins Gene Name GeneID UniProt
EIF2AK3 13666  
EIF2AK3 29702 Q9Z1Z1
EIF2AK3 9451 Q9NZJ5

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PERK Proteins (EIF2AK3) by Origin

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More Proteins for PERK Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. ER-stressed astrocytes can drive an inflammatory M1-like phenotype in microglia, and this can be attenuated with inhibition of PERK. Importantly, targeting PERK neither disrupted normal cytokine signaling in astrocytes or microglia nor impaired macrophage phagocytosis or T cell polarization.

  2. These results suggest that PERK signaling promotes medulloblastoma tumorigenesis by attenuating apoptosis of premalignant granule cell precursors during the course of malignant transformation.

  3. These results suggest that the PERK arm of the unfolded protein response plays a pivotal role in the regulation of satellite cell homeostasis during regenerative myogenesis.

  4. Findings indicate that PERK kinase-activating transcription factor 4 (ATF4 (show ATF4 Proteins)) pathway affected the efficiency of X-box binding protein 1 (XBP1 (show XBP1 Proteins)) mRNA splicing by regulating inositol-requiring enzyme 1alpha (IRE1alpha (show ERN1 Proteins)) expression.

  5. This study demonstrated that Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.

  6. Data show that EIF2AK3/PERK-mediated downregulation of miR (show MLXIP Proteins)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 Proteins) protein and activating transcription factor 6 (ATF6 (show ATF6 Proteins)) during conditions of endoplasmic reticulum stress.

  7. Inhibition of eIF2alpha phosphorylation via PERK suppression and reversal of de novo protein synthesis deficits can mitigate cognitive deficits in neurodegenerative diseases.

  8. PlGF (show PGF Proteins) inhibition attenuates PERK activation, likely by tempering hypoxia in HCC (show FAM126A Proteins) via vessel normalisation. The UPR is able to regulate PlGF (show PGF Proteins) expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR

  9. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK and a downstream effector of its activation, CHOP (show DDIT3 Proteins), in tubule cell production of fibronectin (show FN1 Proteins)

  10. Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. We reveal distinct binding affinities between the binary and ternary complexes thus formed, that suggest a preference for the PERK signaling branch under stress, and a predilection for the GRP78 (show HSPA5 Proteins)-UPR sensor complex formation upon stressor removal. These results imply a gated UPR mechanism that tunes the overall cellular behavior to the accumulation of unfolded proteins.

  2. PERK is involved in multivesicular body information during endoplasmic reticulum stress.

  3. These results suggest that PERK signaling promotes medulloblastoma tumorigenesis by attenuating apoptosis of premalignant granule cell precursors during the course of malignant transformation.

  4. we demonstrate that small molecule PERK inhibitors exhibit single agent efficacy against BrafV600E-dependent tumors highlighting the clinical value of targeting PERK

  5. A novel homozygous nonsense mutation (p.Q333) in exon 5 of the eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) gene in a Wolcott-Rallison syndrome patient, and her parents were first-degree cousins with heterozygous mutations of EIF2AK3 gene.

  6. BiP/GRP78 (show HSPA5 Proteins) and PERK were highly expressed.

  7. plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 Proteins)), protein kinase (show CDK7 Proteins) R (PKR (show PKLR Proteins))like ER kinase (PERK), and inositolrequiring enzyme 1 (IRE1 (show ERN1 Proteins)). Elevated expression of spliced Xbox binding protein 1 (XBP1 (show XBP1 Proteins)) and CCAAT/enhancerbinding protein homologous protein (CHOP (show DDIT3 Proteins)) further confirmed that ROS (show ROS1 Proteins) generatedby NTGP induces apoptosis through the ER stress

  8. PERK-eIF2alpha (show EIF2A Proteins)-ATF4 (show ATF4 Proteins) signaling pathway mediated by endoplasmic reticulum stress involved in osteoblast differentiation of periodontal ligament cells under cyclic mechanical force.

  9. EnR (show LARGE Proteins) stress assessed by expression of PERK and p-eIF2alpha (show EIF2A Proteins) was significantly associated with tumor infiltrating lymphocytes in HER2 (show ERBB2 Proteins)-positive breast cancer.

  10. Influenza A virus downregulates the host unfolded protein response mediated by the PERK protein.

PERK (EIF2AK3) Protein Profile

Protein Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Alternative names and synonyms associated with PERK (EIF2AK3)

  • eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
  • eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3)
  • AI427929 protein
  • EIF2AK3 protein
  • PEK protein
  • PERK protein
  • WRS protein

Protein level used designations for EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3 , eukaryotic translation initiation factor 2-alpha kinase 3-like , PRKR-like endoplasmic reticulum kinase , pancreatic eIF2-alpha kinase , eukaryotic translation initiation factor 2 alpha kinase 3 , hsPEK , pancreatic EIF2-alpha kinase

GENE ID SPECIES
459388 Pan troglodytes
475756 Canis lupus familiaris
699575 Macaca mulatta
100029557 Monodelphis domestica
100066488 Equus caballus
100394186 Callithrix jacchus
100447385 Pongo abelii
100479743 Ailuropoda melanoleuca
13666 Mus musculus
29702 Rattus norvegicus
9451 Homo sapiens
535820 Bos taurus
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